Generation of conditional Cited2 null alleles

Genesis (United States)

Volumn 44, Issue 12, 2006, Pages 579-583

  Preis, Jost I ^a   Wise, Natalie ^a   Solloway, Mark J ^a,c   Harvey, Richard P ^a,b   Sparrow, Duncan B ^a   Dunwoodie, Sally L ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c GENENTECH INC   (United States)

Author keywords

Cited2; Conditional null allele; Cre loxP; Gene targeting

Indexed keywords

BETA GALACTOSIDASE; CELL PROTEIN; CRE RECOMBINASE; PROTEIN CITED; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAULIFLOWER MOSAIC VIRUS; CITED2 GENE; CONTROLLED STUDY; DEVELOPMENTAL GENE; EMBRYO; EMBRYO AXIS; EMBRYO CELL; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; FEMALE; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENETIC PROCEDURES; GENETIC RECOMBINATION; GENOTYPE PHENOTYPE CORRELATION; GERM LINE; HEART DEVELOPMENT; HETEROZYGOTE; HOMOZYGOTE; KNOCKOUT GENE; MALE; MOUSE; MOUSE MUTANT; NEURAL TUBE; NONHUMAN; NULL ALLELE; ORGANOGENESIS; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE; TROPHOBLAST; VASCULARIZATION;

MUS MUSCULUS;

EID: 33845977042     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20251     Document Type: Article

References (25)

1. Bamforth SD, Braganca J, Eloranta JJ, Murdoch JN, Marques FI, Kranc KR, Farza H, Henderson DJ, Hurst HC, Bhattacharya S. 2001. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet 29:469-474.
2. Bamforth SD, Braganca J, Farthing CR, Schneider JE, Broadbent C, Michell AC, Clarke K, Neubauer S, Norris D, Brown NA, Anderson RH, Bhattacharya S. 2004. Cited2 controls left- right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet 36:1189-1196.
3. Barbera JP, Rodriguez TA, Greene ND, Weninger WJ, Simeone A, Copp AJ, Beddington RS, Dunwoodie S. 2002. Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet 11:283-293.
4. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Rung AL, Livingston DM. 1999. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 13:64-75.
5. Chou YT, Wang H, Chen Y, Danielpour D, Yang YC. 2006. Cited2 modulates TGF-β-mediated upregulation of MMP9. Oncogene 25:5547-5560.
6. Chou YT, Yang YC. 2006. Post-transcriptional control of Cited2 by transforming growth factor β. Regulation via Smads and Cited2 coding region. J Biol Chem 281:18451-18462.
7. De Guzman RN, Martinez-Yamout MA, Dyson HJ, Wright PE. 2004. Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: Regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem 279:3042-3049.
8. Dunwoodie SL, Rodriguez TA, Beddington RS. 1998. Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev 72:27-40.
9. Freedman SJ, Sun ZY, Rung AL, France DS, Wagner G, Eck MJ. 2003. Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2. Nat Struct Biol 10:504-512.
10. Glenn DJ, Maurer RA. 1999. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone α-subunit gene expression. J Biol Chem 274:36159-36167.
11. Jeong JW, Lee KY, Kwak I, White LD, Hilsenbeck SG, Lydon JP, DeMayo FJ. 2005. Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor. Endocrinology 146:3490-3505.
12. Kozak M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125-8148.
13. Kranc KR, Bamforth SD, Braganca J, Norbury C, van Lohuizen M, Bhattacharya S. 2003. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol 23:7658-7666.
14. Schneider JE, Bamforth SD, Farthing CR, Clarke K, Neubauer S, Bhattacharya S. 2003. Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol 35:217-222.
15. Schwenk F, Baron U, Rajewsky K. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23:5080-5081.
16. Solloway MJ, Dudley AT, Bikoff EK, Lyons KM, Hogan BL, Robertson EJ. 1998. Mice lacking Bmp6 function. Dev Genet 22:321-339.
17. Stanley EG, Biben C, Elefanty A, Barnett L, Roentgen F, Robb L, Harvey RP. 2002. Efficient Cre- mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol 46:431-439.
18. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP 2005. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132:2451-2462.
19. Sun HB, Zhu YX, Yin T, Sledge G, Yang YC. 1998. MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity. Proc Natl Acad Sci USA 95:13555-13560.
20. Tien ES, Davis JW, Vanden Heuvel JP. 2004. Identification of the CREB-binding protein/p300- interacting protein CITED2 as a peroxisome proliferator-activated receptor α coregulator. J Biol Chem 279:24053-24063.
21. Weninger WJ, Floro KL, Bennett MB, Withington SL, Preis JI, Barbera JP, Mohun TJ, Dunwoodie SL. 2005. Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development 132:1337-1348.
22. Weninger WJ, Mohun T. 2002. Phenotyping transgenic embryos: A rapid 3-D screening method based on episcopic fluorescence image capturing. Nat Genet 30:59-65.
23. Withington SL, Scott AN, Saunders DN, Lopes Floro K, Preis JI, Michalicek J, Maclean K, Sparrow DB, Barbera JP, Dunwoodie SL. 2006. Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol 294:67-82.
24. Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Cordon RA, Hoit BD, Watanabe M, Yang YC. 2002. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci USA 99:10488-10493.
25. Yokota H, Goldring MB, Sun HB. 2003. CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. J Biol Chem 278:47275-47280.