Prophylactic antibiotics in obstetrics-gynecology: A current asset, a future liability?

Expert Review of Anti-Infective Therapy

Volumn 4, Issue 6, 2006, Pages 957-964

  Ledger, William J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

C. difficile; Endogenous bacteria; Group B Streptococcus; Methicillin resistant Staphylococcus aureus; Prophylactic antibiotics

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; ANTIBIOTIC AGENT; CEFALOTIN; CEFAZOLIN; CEFONICID; CEFOTETAN; CEFOXITIN; CEFTIZOXIME; CEPHALOSPORIN DERIVATIVE; CHLORHEXIDINE; CLINDAMYCIN; CLOXACILLIN; ERYTHROMYCIN; GENTAMICIN; HEXACHLOROPHENE; METRONIDAZOLE; NEOMYCIN; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN; PLACEBO; TETRACYCLINE;

ABDOMINAL HYSTERECTOMY; ANTIBIOTIC PROPHYLAXIS; BACTERIUM CONTAMINATION; CESAREAN SECTION; CLOSTRIDIUM DIFFICILE; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GYNECOLOGY; HOSPITAL INFECTION; HUMAN; HYSTEROSALPINGOGRAPHY; INCIDENCE; INFECTION RATE; INFECTIOUS COMPLICATION; LABOR; LONG TERM CARE; MEMBRANE RUPTURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEWBORN; NONHUMAN; OBSTETRICS; POSTOPERATIVE INFECTION; PRACTICE GUIDELINE; PREGNANCY TERMINATION; RADICAL HYSTERECTOMY; REPEATED DRUG DOSE; REVIEW; SHORT COURSE THERAPY; SINGLE DRUG DOSE; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS INFECTION; VAGINAL HYSTERECTOMY;

EID: 33845974448     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.4.6.957     Document Type: Review

References (70)

1. Petersdorf RG, Curtin JA, Hoeprich PD et al. A study of antibiotic prophylaxis in unconscious patients. N. Engl. J. Med. 257, 1001-1009 (1957).
2. Karl RC, Merte JJ, Veith FJ et al. Prophylactic antimicrobial drugs in surgery. N. Engl. J. Med. 275, 305-308 (1966).
3. Burke JF. The effective period of preventive antibiotic action in experimental incision and dermal lesions. Surgery 50, 161-168 (1961).
4. Bernard HR, Lok WR. The prophylaxis of surgical infection: the effect of prophylactic antimicrobial drugs on the incidence of infection following potentially contaminated operations. Surgery 56, 151-157 (1964).
5. Polk H, Lopez-Mayor J. Post-operative wound infection: a prophylactic study of determinant factors and prevention. Surgery 66, 97-102 (1969).
6. Ledger WJ, Gee C, Lewis W. Guidelines for antibiotic prophylaxis in gynecology. Am. J. Obstet. Gynecol. 121, 1038-1045 (1975).
7. Bartlett JG, Onderdonk AB, Drude E et al. Quantitative bacteriology of the vaginal flora. J. Inject. Dis. 136, 271 (1977).
8. Gorbach SL, Menda KB, Thadepalli H et al. Anaerobic microflora of the cervix in healthy women. Am. J. Obstet. Gynecol. 117, 1053-1055 (1973).
9. Hyman RW, Fukushima M, Diamond L et al. PNAS 102, 7952-7957 (2005).
10. Schwebke JR, Richey CM, Weiss HL. Correlations of behaviors with microbiologic changes in vaginal flora. J. Infect. Dis. 180, 1632-1636 (1999).
11. Soper DE, Bump RC, Hurt WG. Bacterial vaginosis and trichomoniasis vaginitis are risk factor for cuff cellulitis after abdominal hysterectomy. Am. J. Obstet. Gynecol. 163, 1016-1023 (1990).
12. Watts H, Krohn MA, Hillier SL et al. Bacterial vaginosis as a risk factor for post-cesarean endometritis. Obstet. Gynecol. 75, 52-58 (1990).
13. Donders GGG, Vereecken A, Bosmans E et al. Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. Br. J. Obstet. Gynecol. 109, 1-10 (2002).
14. Burkman RT Tonascia JA, Atienza MF et al. Untreated endocervical gonorrhea and endometritis following elective abortion. Am. J. Obstet. Gynecol. 126, 648-651 (1976).
15. Moller BR, Ahrens S, Laurin J et al. Pelvic infection after elective abortion associated with Chlamydia trachomatis. Obstet. Gynecol. 59, 210-213 (1982).
16. Wells CL, Jechorek RR Twiggs LB et al. Recovery of viable bacteria from pelvic lymph nodes of patients with gynecologic tumors. J Infect. Dis. 162,1216-1218 (1990).
17. Miller JM Jr, Popkin MJ, Hill GB. Bacterial colonization of amniotic fluid from intact fetal membranes. Am. J. Obstet. Gynecol. 136, 796-804 (1980).
18. Chelmow D, Ruehli MS, Huang E. Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: a meta-analysis. Am. J. Obstet. Gynecol. 184, 656-661 (2001).
19. Platt R, Zalenik DF, Hopkins CC et al. Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery. N. Engl. J. Med. 322, 153-160 (1990).
20. DiZerega G, Yonekura L et al. A comparison of clindamycin-gentamicin and penicillin-gentamicin in the treatment of post-cesarean section endomyometritis. Am. J. Obstet. Gynecol. 134, 238 (1979).
21. Hamod KA, Spence MR, Rosenshein et al. Single-dose and multidose prophylaxis in vaginal hysterectomy: a comparison of sodium cephalothin and metronidazole. Am. J. Obstet. Gynecol. 136, 976-979 (1980).
22. Ledger WJ, Sweet RL, Headington JT. Prophylactic cephalordine in the treatment of post-operative pelvic infection in premenopausal women undergoing vaginal hysterectomy. Am. J. Obstet. Gynecol. 115, 766-774 (1973).
23. Micha JP, Kucera PR, Birkett JP et al. Prophylactic mezlocillin in radical hysterectomy. Obstet. Gynecol. 69, 251-254 (1987).
24. Wong R, Gee CL, Ledger WJ. Prophylactic use of cefazolin in monitored obstetric patients undergoing cesarean section. Obstet. Gynecol. 51, 407-411 (1978).
25. Sawaya GF, Grady O, Kerlikouske K et al. Antibiotics at the time of induced abortions: the case for universal prophylaxis based on a meta-analysis. Obstet. Gynecol. 87, 884-890 (1996).
26. Pittaway DE, Winfield AC, Maxson W et al. Prevention of acute pelvic inflammatory disease after hysterosalpingography: efficacy of doxycycline prophylaxis. Am. J. Obstet. Gynecol. 147, 623-626 (1983).
27. Sinei SKA, Schulz KF, Lamprey PR et al. Preventing IUCD-related pelvic infection: the efficacy of prophylactic doxycycline at insertion. Br. J. Obstet. Gynecol. 97, 412-419 (1990).
28. Mittendorf R, Aronson MP, Berry RE et al. Avoiding serious infections with abdominal hysterectomy: a meta-analysis of antibiotic prophylaxis. Am. J. Obstet. Gynecol. 169, 1119-1124 (1993).
29. Berkeley AS, Hayworth SD, Hirsch JC et al. Controlled comparative study of moxalactam and cefazolin for prophylaxis of abdominal hysterectomy. Surg. Gynecol. Obstet. 161, 457-461 (1985).
30. Tanos V, Rojansky N. Prophylactic antibiotics in abdominal hysterectomy. J. Am. Coll. Surg. 179, 593-600 (1994).
31. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation. Obstet. Gynecol. 107, 1120-1138 (2006).
32. Cunningham FG, Leveno KJ, De Palma RT et al. Perioperative antimicrobials for cesarean delivery: before or after cord clamping? Obstet. Gynecol. 62, 151-154 (1983).
33. Gordon HR, Phelps D, Blanchard K. Prophylactic cesarean section antibiotics: maternal and neonatal morbidity before or after cord clamping. Obstet. Gynecol. 53, 151-156 (1979).
34. Shapiro M, Munoz A, Tager IB et al. Risk factors for infection in the operative site after abdominal or vaginal hysterectomy. N. Engl. J. Med. 307, 1661-1666 (1982).
35. Berkeley SA, Freedman SK, Ledger WJ et al. Comparison of cefotetan and cefoxitin prophylaxis for abdominal and vaginal hysterectomy. Am. J. Obstet. Gynecol. 158, 706-709 (1988).
36. Hemsell DL, Heard ML, Nobles BJ et al. Single-dose cefoxitin prophylaxis for premenopausal women undergoing vaginal hystectomy. Obstet. Gynecol. 63, 285-290 (1984).
37. Price DJE, Sleigh JD. Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics. Lancet 2, 1213-1215 (1980).
38. Blackwell AL, Emery SJ, Thomas PD et al. Universal prophylaxis for Chlamydia trachomatis and anaerobic vaginosis in women attending for suction termination of pregnancy: an audit of short-term health gains. Int. J. STD AIDS 10, 508-513 (1999).
39. Genç, M, Mardh P-A. A cost-effectiveness analysis of screening and treatment for Chlamydia trachomatis infection in asymptomatic women. Ann. Inter. Med. 1241-1247 (1996).
40. Rehu M, Jahkola M. Prophylactic antibiotics in cesarean section: effect of a short pre-operative course of benzyl penicillin or clindamycin plus gentamicin on post-operative infectious morbidity. Ann. Clin. Res. 12, 45-48 (1980).
41. Faro S, Martens MG, Hammill HA et al. Antibiotic prophylaxis: is there a difference? Am. J. Obstet. Gynecol. 162, 900-909 (1990).
42. Hemsell DL, Johnson ER, Heard MC et al. Single-dose piperacillin versus triple dose cefoxitin prophylaxis at vaginal and abdominal hysterectomy. South Med. J. 82, 438-442 (1989).
43. Culver DH, Horan TC, Gaynes RP et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. Am. J. Med. 91, S152-S157 (1991).
44. Zangwill KM, Schuchat A, Wenger JD. Group B Streptococcus disease in the United States, 1990: report from multistage active surveillance system. Morb. Mortal Wkly. Rep. 41, 25-32 (1992).
45. Yow MD, Mason ED, Leeds LJ et al. Ampicillin prevents intrapartum chemoprophylaxis of neonatal Group B streptococcal early-onset disease III. Interruption of mother-to-infant transmission. J. Infect. Dis. 148, 810-816 (1983).
46. Boyer KM, Gadzala CA, Kelly PD et al. Selective intrapartum chemoprophylaxis of neonatal Group B streptococcal early-onset disease III. Interruption of mother to infant transmission. J. Infect. Dis. 148, 810-816 (1983).
47. Centers for Disease Control and Prevention. Prevention of group B streptococcal disease: a public health perspective. MMWR 45(RR-7), 1-24 (1996).
48. Ledger WJ. CDC guidelines for the prevention of perinatal group B streptococcal disease: are they appropriate? Inf. Dis,. Clin. Pract. 7, 188-193 (1998).
49. Ramos RM, McIntire DD, Wendel GD Jr. Antibiotic chemoprophylaxis for group B strep is not necessary with elective cesarean section. Am. J. Obstet. Gynecol. 180, S85 (1999).
50. Hager WD, Schuchat A, Gibbs R et al. Prevention of perinatal group B streptococcal infection: current controversies. Obstet. Gynecol. 96, 141-145 (2000).
51. Schrag SJ, Zell ER, Lynfield R et al. A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates. N. Engl. J. Med. 347, 233-239 (2002).
52. Centers for Disease Control and Prevention. Prevention of group B streptococcal disease: revised guidelines from CDC. MMWR 51(RR-11), 1-24 (2002).
53. Stray-Pedersen B, Bergan T, Hafstad A et al. Vaginal disinfection with chlorhexidine during childbirth. Intl. J. Antimicrob. Agents 12, 245-251 (1999).
54. Nichols RL, Broido P, Condon RE et al. The effect of preoperative neomycin erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Am. Surg. 178, 453-462 (1973).
55. Rouse DJ, Haueh JC, Andrews WW et al. Chlorhexidine vaginal irrigation for the prevention of peripartal infection: a placebo-controlled randomized clinical trial. Am. J. Obstet. Gynecol. 176, 617-622 (1997).
56. Dinsmore MJ, Viloria. R, Lief L et al. Use of intrapartum antibiotics and the incidence of postnatal maternal and neonatal yeast infections. Obstet. Gynecol. 106, 19-22 (2005).
57. Towers CV, Carr MH, Padilla G et al. Potential consequences of widespread antepartal use of ampicillin. Am. J. Obstet. Gynecol. 179, 879-883 (1998).
58. Mayor-Lynn K, Gonzalez-Quintero VH, O'Sullivan MJ et al. Comparison of early onset neonatal sepsis caused by Escherichia coli and group B Streptococcus. Am. J. Obstet. Gynecol. 192, 1437-1439 (2005).
59. Stoll BJ, Hansen Fanaroff AA et al. Changes in pathogen causing early-onset sepsis in very low birth weight infants. N. Engl. J. Med. 347, 240-247 (2002).
60. Mercer B, Miodovnik M, Thurnau G et al. Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of membranes. A randominzed controlled trial. JAMA 278, 989-995 (1997).
61. Kenyon SL, Taylor DJ., Tarnow-Mordi W et al. Broad spectrum antibiotics for preterm prelabor rupture of fetal membranes. The Oracle I randomized trial. Lancet 357, 979-988 (2001).
62. Fridkin SK, Hageman JC, Morrison M et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N. Engl. J. Med. 352, 1436-1444 (2005).
63. Hammill H, Tiran J. CAMRSA the new women's health epidemic. A review of eight recent cases of community-acquired MRSA infections in women. International Infectious Disease Society for Obstetrics and Gynecology-USA. 11th Annual Conference on Women's Health Care Issues. Alexandria, Virginia 5 May (2006).
64. Aroutcheva. A, Rice T, Welbel MA et al. Community-associated methicillin-resistant Staphylococcus aurcus (MRSA) in pregnant and post-partum women and premature newborns. Abstract. International Infectious Disease Society fbr Obstetrics and Gynccology-USA. 11th Annual Conference on Women's Health Care Issues. Alexandria, Virginia 5 May (2006).
65. Eliopoulos GM. Issues with glycopeptides in the treatment of serious Gram-positive infections. Part III review of current treatment options to manage serious Gram-positive infections. Clin. Updates Inf. Dis. 8, 1-6 (2006).
66. Eisen DP Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin. Infect. Dis. 37, 1496-1505 (2003).
67. Warny M, Pepin T, Fang A et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 366, 1079-1084 (2005).
68. Wren SM, Ahmed N, jamal A et al. Preoperative oral antibiotics in colorectal surgery increase the rate of Clostridium difficile colitis. Arch. Surg. 752-756 (2005).
69. Mercer B, Hrodovnik N, Thurnau GR et al. Antiobiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. JAMA 278, 989-995 (1997).
70. Beazley D. Impact of amnionitis and antibiotic treatment on neonatal outcome after PPROM. Am. J. Obstet. Gynecol. S15 (1998).