Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes: A randomized controlled trial

JAMA

Volumn 278, Issue 12, 1997, Pages 989-995

  Mercer, Brian M ^a   Miodovnik, Menachem ^b   Thurnau, Gary R ^c   Goldenberg, Robert L ^d   Das, Anita F ^e   Ramsey, Risa D ^a   Rabello, Yolanda A ^f   Meis, Paul J ^g   Moawad, Atef H ^h   Iams, Jay D ⁱ   Van Dorsten, J Peter ^j   Paul, Richard H ^f   Bottoms, Sidney F ^k   Merenstein, Gerald ^l   Thom, Elizabeth A ^e   Roberts, James M ^m   McNellis, Donald ⁿ  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g WAKE FOREST SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF CHICAGO   (United States)

ⁱ OHIO STATE UNIVERSITY   (United States)

^j MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^k WAYNE STATE UNIVERSITY   (United States)

^l UNIVERSITY OF COLORADO   (United States)

^m UNIVERSITY OF PITTSBURGH   (United States)

ⁿ EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ERYTHROMYCIN; PLACEBO;

ADULT; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTRAUTERINE INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NEWBORN MORBIDITY; ORAL DRUG ADMINISTRATION; PATIENT CARE; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STREPTOCOCCUS AGALACTIAE; TOCOLYSIS; TREATMENT OUTCOME;

EID: 0006750594     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.278.12.989     Document Type: Article

References (37)

1. Meis PJ, Ernest JM, Moore ML. Causes of low birth weight births in public and private patients. Am J Obstet Gynecol. 1987;156:1165-1168.
2. Alger LS, Lovchik JC, Hebel JR, Blackmon LR, Crenshaw MC. The association of Chlamydia trachomatis, Neisseria gonorrhoeae, and group B streptococci with preterm rupture of the membranes and pregnancy outcome. Am J Obstet Gynecol. 1988;159:397-404.
3. Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol. 1992;166: 1515-1528.
4. McGregor JA. Prevention of preterm birth: new initiatives based on microbial-host interactions. Obstet Gynecol Surv. 1988;43:1-13.
5. Hillier SL, Witkin SS, Krohn MA, Watts DH, Kiviat NB, Eschenbach DA. The relationship of amniotic fluid cytokines in preterm delivery, amniotic fluid infection, histologic horioamnionitis, and chorioamnion infection. Obstet Gynecol. 1993;81:941-948.
6. Mercer B, Moretti M, Rogers R, Sibai B. Antibiotic prophylaxis in preterm premature rupture of the membranes: prospective randomized double-blind trial of 220 patients. Am J Obstet Gynecol. 1992;166:794-802.
7. Amon E, Lewis SV, Sibai BM, Villar MA, Arheart KL. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol. 1988;159: 539-543.
8. Johnston MM, Sanchez-Ramos L, Vaughn AJ, Todd MW, Benrubi GI. Antibiotic therapy in preterm premature rupture of the membranes: a randomized prospective double-blind trial. Am J Obstet Gynecol. 1990;163:743-747.
9. McGregor JA, French JI, Seo K. Antimicrobial therapy in preterm premature rupture of membranes: results of a prospective, double-blind, placebo-controlled trial of erythromycin. Am J Obstet Gynecol. 1991;165:632-640.
10. Christmas JT, Cox SM, Andrews W, Dax J, Leveno KJ, Gilstrap LC. Expectant management of preterm ruptured membranes: effects of antimicrobial therapy. Obstet Gynecol. 1992;80:759-762.
11. Lockwood CJ, Costigan K, Ghidini A, et al. Double-blind placebo-controlled trial of Piperacillin prophylaxis in preterm membrane rupture. Am J Obstet Gynecol. 1993;169:970-976.
12. Morales WJ, Angel JL, O'Brien WF, Knuppel RA. Use of ampicillin and corticosteroids in premature rupture of the membranes: a randomized study. Obstet Gynecol. 1989;73:721-726.
13. Prevention of early-onset group B streptococcal disease in newborns. In: Committee Opinion: ACOG Committee on Obstetric Practice. Washington, DC: American College of Obstetricians and Gynecologists; June 1996:1-8.
14. Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics. Guidelines for prevention of group B streptococcal (GBS) infection by chemoprophylaxis. Pediatrics. 1992;90:775-778.
15. Schuchat A. Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR Morb Mortal Wkly Rep. 1996;45:1-24.
16. Wei LJ, Lachin JM. Properties of urn randomization in clinical trials. Control Clin Trials. 1988;9: 345-364.
17. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika. 1983;70: 659-663.
18. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics. 1979;35:549-556.
19. National Institutes of Health Consensus Development Conference Statement: effects of corticosteroids for fetal maturation on perinatal outcomes, February 28-March 2, 1994. Am J Obstet Gynecol. 1995;173:246-252.
20. Mercer B, Arheart K. Antimicrobial therapy in expectant management of preterm premature rupture of the membranes. Lancet. 1995;346:1271-1279.
21. Garite TJ, Freeman RK. Chorioamnionitis in the preterm gestation. Obstet Gynecol. 1982;59:539-545.
22. Romero R, Ghidini A, Mazor M, Behnke E. Microbial invasion of the amniotic cavity in premature rupture of membranes. Clin Obstet Gynecol. 1991; 34:769-778.
23. Cotton DB, Hill LM, Strassner HT, Platt LD, Ledger WJ. The use of amniocentesis in preterm gestation with ruptured membranes. Obstet Gynecol. 1984;63:38-48.
24. Vintzileos AL, Campbell WA, Nochimson DJ, Weinbaum PJ, Escoto DT, Mirochnick MH. Qualitative amniotic fluid volume versus amniocentesis in predicting infection in preterm premature rupture of the membranes. Obstet Gynecol. 1986;67:579-583.
25. Romero R, Quintero R, Oyarzune K, et al. Intra-amniotic infection in the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol. 1988;159:661-666.
26. Gochay DW, Meyer WJ, Bieniarz A. Biophysical profile as a predictor of amniotic fluid culture results. Obstet Gynecol. 1992;80:102-105.
27. Broekhuizen FF, Gilman M, Hamilton PR. Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. Obstet Gynecol. 1986;66:316-321.
28. Romero R, Emamian M, Quintero R, et al. The value and limitations of the gram stain examination in the diagnosis of intra-amniotic infection. Am J Obstet Gynecol. 1988;159:114-119.
29. McCaul JF, Perry KG, Moore JL, Martin RW, Bucovaz ED, Morrison JC. Adjunctive antibiotic treatment of women with preterm rupture of membranes or preterm labor. Int J Gynecol Obstet. 1992;38:19-24.
30. Kurki T, Hallman M, Zilliacus R, Teramo K, Ylikorkala O. Premature rupture of the membranes: effect of penicillin prophylaxis and long-term outcome of the children. Am J Perinatol. 1992;9:11-16.
31. Blanco J, lams J, Artal R, et al. Multicenter double-blind prospective random trial of ceftizoxime vs. placebo in women with preterm premature ruptured membranes (pPROM). Am J Obstet Gynecol. 1993;168:378. Abstract.
32. Owen J, Groome LJ, Hauth JC. Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture. Am J Obstet Gynecol. 1993; 169:976-981.
33. Ernest JM, Givner LB. A prospective randomized placebo-control trial of penicillin in preterm premature rupture of membranes. Am J Obstet Gynecol. 1994;170:516-521.
34. Dunlop PDM, Crowley PA, Lamont RF, Hawkins DF. Preterm ruptured membranes, no contractions. J Obstet Gynecol. 1986;7:92-96.
35. Gordon M, Weingold AB. Treatment of patients with rupture of the fetal membranes: (a) prior to 32 weeks; (b) after 32 weeks. Controvers Obstet Gynecol. 1974;2:42-44.
36. Debodinance P, Parmentier D, Devulder G, Closset P, Querleu D, Crepin G IV. Peut-on reduire le risque infectieux neonatal dans les ruptures prematurees des membranes. J Gynecol Obstet Biol Reprod (Paris). 1990;19:533-536.
37. Lewis DF, Fontenot MT, Brooks GG, Wise R, Perkins MB, Heymann AR. Latency period after preterm premature rupture of the membranes: a comparison of ampicillin with and without sulbactam. Obstet Gynecol. 1995;86:392-395.