Concurrent chemoradiotherapy followed by adjuvant chemotherapy in uterine cervical cancer patients with high-risk factors

Gynecologic Oncology

Volumn 104, Issue 1, 2007, Pages 58-63

  Kim, Yong Bae ^a,b   Cho, Jae Ho ^a,b   Keum, Ki Chang ^a,b   Lee, Chang Geol ^a,b   Seong, Jinsil ^a,b   Suh, Chang Ok ^a,b   Kim, Gwi Eon ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Adjuvant chemotherapy; Concurrent chemoradiotherapy; Uterine cervical cancer

Indexed keywords

CARBOPLATIN; CISPLATIN; FLUOROURACIL;

ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; COMPARATIVE STUDY; DISEASE FREE SURVIVAL; EARLY CANCER; FEMALE; GASTROINTESTINAL TOXICITY; HEMATOLOGIC DISEASE; HIGH RISK PATIENT; HUMAN; HYPOKALEMIA; INFECTION; LEUKOPENIA; LIVER TOXICITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; MORBIDITY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEPHROTOXICITY; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; PROGNOSIS; RADIATION SICKNESS; RETROSPECTIVE STUDY; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; UTERINE CERVIX CANCER; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRACHYTHERAPY; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; CISPLATIN; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; HUMANS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RADIOTHERAPY; RETROSPECTIVE STUDIES; RISK FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 33845968526     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2006.07.005     Document Type: Article

References (16)

1. Perez C.A., Breaux S., Madoc-Jones H., Bedwinek J.M., Camel H.M., Purdy J.A., et al. Radiation therapy alone in the treatment of carcinoma of uterine cervix. I. Analysis of tumor recurrence. Cancer 51 (1983) 1393-1402
2. Park T.K. Carcinoma of the uterine cervix: an analysis of treatment failures and suggested therapeutic strategies. Korean J. Obstet. Gynecol. 29 (1986) 617-641
3. Piver M.S., and Chung W.S. Prognostic significance of cervical lesion size and pelvic node metastases in cervical carcinoma. Obstet. Gynecol. 46 (1975) 507-510
4. Morris M., Eifel P.J., Lu J., Grigsby P.W., Levenback C., Stevens R.E., et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N. Engl. J. Med. 340 (1999) 1137-1143
5. Keys H.M., Bundy B.N., Stehman F.B., Muderspach L.I., Chafe W.E., Suggs III C.L., et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N. Engl. J. Med. 340 (1999) 1154-1161
6. Peters III W.A., Liu P.Y., Barrett II R.J., Stock R.J., Monk B.J., Berek J.S., et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol. 18 (2000) 1606-1613
7. Whitney C.W., Sause W., Bundy B.N., Malfetano J.H., Hannigan E.V., Fowler Jr. W.C., et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J. Clin. Oncol. 17 (1999) 1339-1348
8. Rose P.G., Bundy B.N., Watkins E.B., Thigpen J.T., Deppe G., Maiman M.A., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N. Engl. J. Med. 340 (1999) 1144-1153
9. NCI clinical announcement: concurrent chemoradiation for cervical cancer (1999), United States Department of Public Health, Washington, DC
10. Stehman F.B., Bundy B.N., Hanjani P., Fowler W.C., Abdulhay G., and Whitney C.W. Biopsy of the scalene fat pad in carcinoma of the cervix uteri metastatic to the periaortic lymph nodes. Surg. Gynecol. Obstet. 165 (1987) 503-506
11. Wong L.C., Ngan H.Y., Cheung A.N., Cheng D.K., Ng T.Y., and Choy D.T. Chemoradiation and adjuvant chemotherapy in cervical cancer. J. Clin. Oncol. 17 (1999) 2055-2060
12. Lorvidhaya V., Chitapanarux I., Sangruchi S., Lertsanguansinchai P., Kongthanarat Y., Tangkaratt S., et al. Concurrent mitomycin C, 5-fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial. Int. J. Radiat. Oncol. Biol. Phys. 55 (2003) 1226-1232
13. Follen M., Levenback C.F., Iyer R.B., Grigsby P.W., Boss E.A., Delpassand E.S., et al. Imaging in cervical cancer. Cancer 98 (2003) 2028-2038
14. Park T.K., Kim S.N., Kim S.W., Kim G.E., and Suh C.O. Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors. J. Korean Med. Sci. 15 (2000) 436-441
15. Rose P.G. Chemoradiotherapy for cervical cancer. Eur. J. Cancer 38 (2002) 270-278
16. Ryu H.S. Concurrent chemoradiotherapy in cervical cancer (a new paradigm in cervical cancer treatment). Yonsei Med. J. 43 (2002) 749-753