Constitutive activation of NF-κB is not sufficient to disturb normal steady-state hematopoiesis

Haematologica

Volumn 91, Issue 12, 2006, Pages 1710-1711

  Schepers, Hein ^a,b   Eggen, Bart J L ^b   Schuringa, Jan Jacob ^a   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Differentiation; IKK2; Leukemia; NF B; Proliferation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; ENZYME ACTIVATION; HEMATOPOIESIS; HUMAN; STEM CELL;

CELL LINE; HEMATOPOIESIS; HUMANS; NF-KAPPA B;

EID: 33845954687     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Birkenkamp KU, Geugien M, Schepers H, Westra J, Lemmink HH, Vellenga E. Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway. Leukemia 2004;18:103-12.
2. Baumgartner B, Weber M, Quirling M, Fischer C, Page S, Adam M, et al. Increased IκB kinase activity is associated with activated NF-κB in acute myeloid blasts. Leukemia 2002;16:2062-71.
3. Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001;98:2301-7.
4. Narayanan R, Klement JF, Ruben SM, Higgins KA, Rosen CA. Identification of a naturally occurring transforming variant of the p65 subunit of NF-κ B. Science 1992;256:367-70.
5. Fan Y, Rayet B. Gelinas C. Divergent C-terminal transactivation domains of Rel/NF-ê B proteins are critical determinants of their oncogenic potential in lymphocytes. Oncogene 2004;23:1030-42.
6. Grossmann M, Metcalf D, Merryfull J, Beg A, Baltimore D, Gerondakis S. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc Natl Acad Sci USA 1999;96:11848-53.
7. Nakata S, Matsumura I, Tanaka H, Ezoe S, Satoh Y, Ishikawa J, et al. NF-κB family proteins participate in multiple steps of hematopoiesis through elimination or reactive oxygen species. J Biol Chem 2004;279:55578-86.
8. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 1997;278:860-6.
9. Wierenga AT, Schepers H, Moore MA, Vellenga E, Schuringa JJ. STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha. Blood 2006;107:4326-33.
10. + cells. Leukemia 2003;17:1190-2.