Fractionated ionizing radiation exposure induces apoptosis through caspase-3 activation and reactive oxygen species generation

Anticancer Research

Volumn 26, Issue 6 B, 2006, Pages 4549-4557

  Bucci, Barbara ^a   Misiti, Silvia ^b   Cannizzaro, Annapaola ^a   Marchese, Rodolfo ^a   Raza, Giorgio H ^a   Miceli, Roberto ^a   Stigliano, Antonio ^b   Amendola, Donatella ^a   Monti, Olimpia ^a   Biancolella, Michela ^c   Amati, Francesca ^c   Novelli, Giuseppe ^a,c   Vecchione, Aldo ^d   Brunetti, Ercole ^a   De Paula, Ugo ^b  

^a FATEBENEFRATELLI HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Apoptosis; Astrocytoma; Microarray; Radiotherapy; ROS content

Indexed keywords

CASPASE 3; CYTOCHROME P450; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 90; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; ASTROCYTOMA; CANCER RADIOTHERAPY; CELL CYCLE PHASE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE; UPREGULATION;

APOPTOSIS; ASTROCYTOMA; BLOTTING, WESTERN; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; DOSE FRACTIONATION; ENZYME ACTIVATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES;

EID: 33845931293     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kristiansen K, Hagen S, Kollevold T, Torvik A, Holme I, Nesbakken R, Hatlevoll R, Lindgren M and Elgen K: Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multi center trial of the Scandinavian Glioblastoma Study Group. Cancer 47: 649-652, 1981.
2. Nelson DF, Diener-West M, Weinstein AS, Schoenfeld D, Nelson JS, Sause WT, Chang CH and Carabell S: A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery: final report of an RTOG study. Int J Radiat Oncol Biol Phys 12: 1793-1800, 1986.
3. Deutch M, Green SB, Strike TA, Burger PC, Robertson JT, Selker RG, Shapiro WR, Mealey J Jr, Ransohoff J II and Paoletti P: Results of randomized trial comparing BCNU plus radiotherapy, streptozocin plus radiotherapy, BCNU plus hyper fractionated radiotherapy, and BCNU following misonidasole plus radiotherapy in the post-operative treatment of malignant glioma. Int J Radiat Oncol Biol Phys 16: 1389-1396, 1989.
4. Withers HR: Biologic basis for altered fractionated schemes. Cancer 55: 2086-2095, 1985.
5. Reed JC: Regulation of apoptosis by BCL-2 family proteins and its role in cancer and chemo resistance. Curr Opin Oncol 7: 541-546, 1995.
6. Meyn RE, Stephens LC and Milas L: Programmed cell death and radio resistance. Cancer Metastasis Rev 15: 119-131, 1996.
7. Chendil D, Oakesm R, Alcock RA, Patel N, Mayhew C, Mohiuddin M, Gallicchio VS and Ahmed MM: Low dose fractionated radiation enhances the radio sensitization effect of paclitaxel in colorectal tumor cells with mutant p53. Cancer 89: 1893-1900, 2000.
8. Whyte M and Evan G: Apoptosis. The last cut is the deepest. Nature 376: 17-18, 1995.
9. Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K and Strasser A: Apoptosis initiated by Bcl-2-regulated caspase activation independently of cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637, 2002.
10. Essmann F, Wieder T, Otto A, Muller EC, Dorken B and Daniel PT: GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis. Biochem J 346: 777-783, 2000.
11. Soldani C and Scovassi AI: Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. 2002. Apoptosis 7: 321-328, 2002.
12. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620, 1997.
13. Biroccio A, Benassi B, Amodei S, Gabellini C, Del Bufalo D and Zupi G: c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells. Mol Pharmacol 60: 174-182, 2001.
14. Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, Khaletskiy A, Li Z, Weydert C and Li JJ: Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol 23: 2362-2378, 2003.
15. Derouet-Humbert E, Roemer K and Bureik M: Adrenoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by generation of reactive oxygen species in mitochondria. Biol Chem 386: 453-461, 2005.
16. Lee YJ, Lee DH, Cho CK, Chung HY, Bae S, Jhon GJ, Soh JW, Jeoung DI, Lee SJ and Lee YS: HSP25 inhibits radiation-induced apoptosis through reduction of PKC delta-mediated ROS production. Oncogene 24: 3715-3725, 2005.
17. De Risi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA and Trent JM: Use of a cDNA micro array to analyze gene expression patterns in human cancer. Nat Genet 14: 457-460, 1996.
18. Williams MV, Denekamp J and Fowler JF: A review of α/β ratios for experimental tumors. Int J Radiat Oncol Biol Phys 11: 87-96, 1985.
19. Bucci B, D'Agnano I, Amendola D, Citti A, Raza GH, Miceli R, De Paula U, Marchese R, Albini S and Vecchione A: Myc downregulation sensitizes melanoma cells to radiotherapy by inhibiting MLH1 and MSH2 mismatch repair proteins. Clin Cancer Res 11: 2756-2767, 2005.
20. D'Agnano I, Antonelli A, Bucci B, Marcucci L, Petrinelli P, Ambra R, Zupi G and Elli R: Effects of poly (ADP-ribose) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin. Environ Mol Mutagen 32: 56-63, 1998.
21. Louagie H, Cornelissen M, Philippe J, Vral A, Thierens H and De Ridder L: Flow cytometric scoring of apoptosis compared to electron microscopy in γ irradiated lymphocytes. Cell Biol Int 22: 277-283, 1998.
22. Steel GG: The case against apoptosis. Acta Oncol 40: 968-975, 2001.
23. Ngo FQ, Blakely EA, Tobias CA, Chang PY and Lommel L: Sequential exposures of mammalian cells to low- and high-LET radiations. II. As a function of cell cycle stages. Radiat Res 115: 54-69, 1998.
24. Kal HB, Hatfield M and Hahn GM: Cell cycle progression of murine sarcoma cells after X irradiation or heat shock. Radiology 117: 215-217, 1975.
25. Lucke-Huhle C, Blakely EA, Chang PY and Tobias CA: Drastic G2 arrest in mammalian cells after irradiation with heavy-ion beams. Radiat Res 79: 97-112, 1979.
26. Geldof AA, Plaizier MA, Duivenvoorden I, Ringelberg M, Versteegh RT, Newling DW and Teule GJ: Cell cycle perturbations and radio sensitization effects in a human prostate cancer cell line. J Cancer Res Clin Oncol 129: 175-182, 2003.
27. Tsoncheva VL, Kirov KS, Valkova CA and Milchev GI: Evaluation of delayed apoptotic response in lethally irradiated human melanoma cell lines. Z Naturforsch [C] 56: 660-665, 2001.
28. Liqun X, Aimee P and Li JJ: p53 Activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. Cancer Research 64: 221-228, 2004.
29. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG: Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53: 3976-3985, 1993.
30. Lennon SV, Martin SJ and Cotter TG: Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif 24: 203-214, 1991.
31. Hockenbery H, Oltvai ZN, Yin XM, Milliman CL and Korsmeyer SJ: Bcl-2 functions as an anti-oxidant pathway to prevent apoptisis. Cell 75: 241-251, 1993.
32. Park WY, Hwang CI, Im CN, Kang MJ, Woo JH, Kim JH, Kim YS, Kim JH, Kim H, Kim KA, Yu HJ, Lee SJ, Lee YS and Seo JS: Identification of radiation-specific responses from gene expression profile. Oncogene 21: 8521-8528, 2002.