Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent

Neuropharmacology

Volumn 52, Issue 1, 2007, Pages 100-107

  Lavezzari, Gabriela ^a   Roche, Katherine W ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Arf6; Clathrin; Endocytosis; Metabotropic glutamate receptors

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; CLATHRIN; GLUTAMATE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 7; PROTEIN DERIVATIVE;

ARTICLE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; INTERNALIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADP-RIBOSYLATION FACTORS; ANIMALS; ANTIGENS, CD95; CELLS, CULTURED; CLATHRIN; EMBRYO; ENDOCYTOSIS; ENDOSOMES; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MUTAGENESIS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SUCROSE; TRANSFECTION; TRANSFERRIN;

EID: 33845866329     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.07.011     Document Type: Article

References (26)

1. Anwyl R. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res. Brain Res. Rev. 29 (1999) 83-120
2. Carroll R.C., Beattie E.C., Xia H., Luscher C., Altschuler Y., Nicoll R.A., Malenka R.C., and von Zastrow M. Dynamin-dependent endocytosis of ionotropic glutamate receptors. Proc. Natl. Acad. Sci. U.S.A 96 (1999) 14112-14117
3. Claing A. Regulation of G protein-coupled receptor endocytosis by ARF6 GTP-binding proteins. Biochem. Cell Biol. 82 (2004) 610-617
4. Conn P.J. Physiological roles and therapeutic potential of metabotropic glutamate receptors. Ann. N.Y. Acad. Sci. 1003 (2003) 12-21
5. Dhami G.K., and Ferguson S.S. Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol. Ther. 111 1 (2006) 260-271
6. Donaldson J.G. Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane. J. Biol. Chem. 278 (2003) 41573-41576
7. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53 (2001) 1-24
8. Fourgeaud L., Bessis A.S., Rossignol F., Pin J.P., Olivo-Marin J.C., and Hemar A. The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. J. Biol. Chem. 278 (2003) 12222-12230
9. Gainetdinov R.R., Premont R.T., Bohn L.M., Lefkowitz R.J., and Caron M.G. Desensitization of G protein-coupled receptors and neuronal functions. Annu. Rev. Neurosci. 27 (2004) 107-144
10. Heuser J.E., and Anderson R.G. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J. Cell Biol. 108 (1989) 389-400
11. Iacovelli L., Capobianco L., Iula M., Di Giorgi Gerevini V., Picascia A., Blahos J., Melchiorri D., Nicoletti F., and De Blasi A. Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). Mol. Pharmacol. 65 (2004) 1103-1110
12. Kittler J.T., Delmas P., Jovanovic J.N., Brown D.A., Smart T.G., and Moss S.J. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J. Neurosci. 20 (2000) 7972-7977
13. Lavezzari G., McCallum J., Lee R., and Roche K.W. Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. Neuropharmacology 45 (2003) 729-737
14. Lavezzari G., McCallum J., Dewey C.M., and Roche K.W. Subunit-specific regulation of NMDA receptor endocytosis. J. Neurosci. 24 (2004) 6383-6391
15. Mathiesen J.M., and Ramirez M.T. The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation. Br. J. Pharmacol. 148 (2006) 279-290
16. Maxfield F.R., and McGraw T.E. Endocytic recycling. Nat. Rev. Mol. Cell Biol. 5 (2004) 121-132
17. Naslavsky N., Weigert R., and Donaldson J.G. Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides. Mol. Biol. Cell 14 (2003) 417-431
18. Naslavsky N., Weigert R., and Donaldson J.G. Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Mol. Biol. Cell 15 (2004) 3542-3552
19. Pelkey K.A., Lavezzari G., Racca C., Roche K.W., and McBain C.J. mGluR7 is a metaplastic switch controlling bidirectional plasticity of feedforward inhibition. Neuron 46 (2005) 89-102
20. Pin J.P., and Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr. Drug Targets CNS Neurol. Disord. 1 (2002) 297-317
21. Roche K.W., and Huganir R.L. Synaptic expression of the high-affinity kainate receptor subunit KA2 in hippocampal cultures. Neuroscience 69 (1995) 383-393
22. Schoepp D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J. Pharmacol. Exp. Ther. 299 (2001) 12-20
23. Shigemoto R., Kinoshita A., Wada E., Nomura S., Ohishi H., Takada M., Flor P.J., Neki A., Abe T., Nakanishi S., and Mizuno N. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci. 17 (1997) 7503-7522
24. Tong Q., and Kirchgessner A.L. Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2003) G992-G1003
25. von Zastrow M. Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sci. 74 (2003) 217-224
26. Weigert R., Yeung A.C., Li J., and Donaldson J.G. Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Mol. Biol. Cell 15 (2004) 3758-3770