Adenovirus-mediated gene transfer of Bcl-xL prevents cell death in primary neuronal culture of the rat

Neuroscience Letters

Volumn 270, Issue 3, 1999, Pages 177-180

  Matsuoka, Norihiro ^a   Yukawa, Hiroyuki ^a   Ishii, Kazuhiro ^a   Hamada, Hirofumi ^b   Akimoto, Masayuki ^c   Hashimoto, Nobuo ^a   Miyatake, Shin Ichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Dept of Molec Biotherapy Research   (Japan)

^c SHINSHU UNIVERSITY   (Japan)

Author keywords

Adenovirus; Apoptosis; Bcl xL; Gene transfer; Neuronal cell death; Primary neuronal culture

Indexed keywords

PROTEIN BCL X; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL PROTECTION; EMBRYO; GENE TRANSFER; IMMUNOBLOTTING; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR;

EID: 0033529786     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00499-1     Document Type: Article

References (15)

1. Akimoto M., Miyatake S., Kogishi J., Hangai M., Okazaki K., Takahashi J.C., Saiki M., Iwaki M., Honda Y. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats. Invest. Ophthalmol. Vis. Sci. 40:1999;273-279.
2. Bakhshi A., Jensen J.P., Goldman P., Wright J.J., McBride O.W., Epstein A.L., Korsmeyer S.J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell. 41:1985;899-906.
3. Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., Thompson C.B. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 27:1993;597-608.
4. Chang G.Q., Hao Y., Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron. 11:1993;595-605.
5. Chittenden T., Harrington E.A., O'Connor R., Flemington C., Lutz R.J., Evan G.I., Guild B.C. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 374:1995;733-736.
6. Hengartner M.O., Horvitz H.R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell. 76:1994;665-676.
7. Ishii K., Katayama M., Hon K., Yodoi J., Nakanishi T. Effects of 2-mercaptoethanol on survival and differentiation of fetal mouse brain neurons cultured in vitro. Neurosci. Lett. 163:1993;159-162.
8. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ord T., Bredesen D.E. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 262:1993;1274-1277.
9. Kanegae Y., Takamori K., Sato Y., Lee G., Nakai M., Saito I. Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene. 181:1996;207-212.
10. Katayama M., Ishii K. 2-Mercaptoethanol-independent survival of fetal mouse brain neurons cultured in a medium of human serum. Brain Res. 656:1994;409-412.
11. Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the bcl-2 oncoprotem: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53:1993;4701-4714.
12. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
13. Oppenheim R.W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14:1991;453-501.
14. Raff M.C., Barres B.A., Burne J.F., Coles H.S., Ishizaki Y., Jacobson M.D. Programmed cell death and the control of cell survival. Philos. Trans. R. Soc. Lond. B Biol. Sci. 345:1994;265-268.
15. Yang E., Tha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 80:1995;285-291.