Hyperhomocysteinemia is associated with deep venous thrombosis of the lower extremities in Tunisian patients

Clinical Biochemistry

Volumn 40, Issue 1-2, 2007, Pages 41-45

  Omar, Souheil ^a   Ghorbel, Imed Ben ^a   Feki, Habib ^b   Souissi, Malek ^a   Feki, Moncef ^a   Houman, Habib ^a   Kaabachi, Neziha ^a  

^a LA RABTA HOSPITAL   (Tunisia)

^b HEDI CHAKER HOSPITAL   (Tunisia)

Author keywords

Deep venous thrombosis; Folic acid; Homocysteine; Hyperhomocysteinemia; Recurrent deep venous thrombosis; Venous thromboembolism; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; ENZYME IMMUNOASSAY; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; LEG; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TUNISIA; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CREATININE; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LEG; MALE; MIDDLE AGED; PREVALENCE; RECURRENCE; TUNISIA; VENOUS THROMBOSIS; VITAMIN B 12;

EID: 33845763470     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2006.08.007     Document Type: Article

References (33)

1. Heit J.A. Risk factors for venous thromboembolism. Clin. Chest Med. 24 (2003) 1-12
2. Mudd S.H. Disorders of transulfuration. In: Scriver C.R., Baudet A.L., and Sly W.S. (Eds). The metabolic and molecular basis of inherited disease (1995), Mc-Graw-Hill, New York 1279-1327
3. Jacques P.F., Bostom A.G., Wilson P.W., Rich S., Rosenberg I.H., and Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am. J. Clin. Nutr. 73 (2001) 613-621
4. Herrmann W., Schorr H., Geisel J., and Riegel W. The importance of hyperhomocysteinemia as a risk factor for diseases: an overview. Clin. Chem. Lab. Med. 39 (2001) 666-674
5. Boushey C.J., Beresford S.A., Omenn G.S., and Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J. Am. Med. Assoc. 274 (1995) 1049-1057
6. Welch G.N., and Loscalzo J. Homocysteine and atherothrombosis. N. Engl. J. Med. 338 (1998) 1042-1050
7. Lawrence de Koning A.B., Werstuck G.H., Zhou J., and Austin R.C. Hyperhomocysteinemia and its role in the development of atherosclerosis. Clin. Biochem. 36 (2003) 431-441
8. Bienvenu T., Ankri A., Chadefaux B., and Kamoun P. Plasma homocysteine assay in the exploration of thrombosis in young subjects. Presse Med. 20 (1991) 985-988
9. Brattstrom L. Plasma homocysteine in venous thromboembolism. Haemostasis 21 (1991) 51-57
10. Amundsen T., Ueland P.M., and Waage A. Plasma homocysteine levels in patients with deep venous thrombosis. Arterioscler. Thromb. Vasc. Biol. 1 (1995) 1321-1323
11. Petri M., Roubenoff R., Dallal G.E., Nadeau M.R., Selhub J., and Rosenberg I.H. Plasma homocysteine as a risk factor for atherothrombotic events in systematic lupus erythematosus. Lancet 348 (1996) 1020-1024
12. den Heijer M., Koster T., Blom H.J., et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N. Engl. J. Med. 334 (1996) 759-762
13. Ridker P.M., Hennekens C.H., Selhub J., Miletich J.P., Malinow M.R., and Stampfer M.J. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 95 (1997) 1777-1782
14. Cattaneo M. Hyperhomocysteinemia and thrombosis. Lipids 36 (2001) S13-S26 [Suppl]
15. Quere I., Perneger T.V., Zittoun J., et al. Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lancet 359 (2002) 747-752
16. Feki M., Houman H., Ghannouchi M., et al. Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behcet's disease. Clin. Chem. Lab. Med. 42 (2004) 1417-1423
17. World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO expert committee, WHO Technical Report Series, no 854, p. 321-44. WHO: Geneva, 1995.
18. Cockroft D.W., and Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron 16 (1976) 31-41
19. den Heijer M., Rosendaal F.R., Blom H.J., Gerrits W.B., and Bos G.M. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb. Haemostasis 80 (1998) 874-877
20. Ray J.G. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch. Intern. Med. 158 (1998) 2101-2106
21. Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb. Haemostasis 81 (1999) 165-176
22. Eichinger S., Stumpflen A., Hirschl M., et al. Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism. Thromb. Haemostasis 80 (1998) 566-569
23. den Heijer M., Lewington S., and Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J. Thromb. Haemostasis 3 (2005) 292-299
24. 12 and venous thromboembolic disease in elderly men. J. Intern. Med. 258 (2005) 244-249
25. den Heijer M. Are B vitamins a risk factor for VTE? Perhaps. J. Thromb. Haemost. 4 (2006) 309-311 [Review]
26. Nasraoui A., and Achour A. La ration alimentaire du Tunisien. Influence du milieu d'habitat. Med. Nutr. 26 (1990) 362-364
27. Wilson K.M., Dayal S., Bottiglieri T., and Lentz S.R. Hyperhomocysteinemic mice have increased susceptibility to carotid artery thrombosis. Blood 104 (2004) 261
28. Dayal S., Bottiglieri T., Arning E., et al. Endothelial dysfunction and elevation of S-adenosyl-homocysteine in cystathionine beta-synthase-deficient mice. Circ. Res. 88 (2001) 1203-1209
29. Fryer R.H., Wilson B.D., Gubler D.B., Fitzgerald L.A., and Rodgers G.M. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler. Thromb. 13 (1993) 1327-1333
30. Khajuria A., and Houston D.S. Induction of monocyte tissue factor expression by homocysteine: a possible mechanism for thrombosis. Blood 96 (2000) 966-972
31. Davi G., Di Minno G., Coppola A., et al. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation 104 (2001) 1124-1128
32. Hajjar K.A., Mauri L., Jacovina A.T., et al. Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J. Biol. Chem. 273 (1998) 9987-9993
33. Ling Q., Jacovina A.T., Deora A., et al. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J. Clin. Invest. 113 (2004) 38-48