Conserved role of brain-derived neurotrophic factor in Val66Met: Target-selective reinforcement of GABAergic synapses

NeuroReport

Volumn 17, Issue 18, 2006, Pages 1847-1851

  Ikeda, Takamitsu ^a   Tamura, Naohiro ^a   Matsuki, Norio ^a   Yamada, Maki K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Brain derived neurotrophic factor; Constitutive secretion; Glutamate decarboxylase; Inhibitory; Interneuron; Single nucleotide polymorphism; Target selective inhibition; Trk

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE DECARBOXYLASE 65; METHIONINE; VALINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FETUS; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; HIPPOCAMPUS; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE; WILD TYPE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; EMBRYO; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; METHIONINE; NEURONS; POLYMORPHISM, GENETIC; PROBABILITY; RATS; RATS, WISTAR; SYNAPSES; TRANSFECTION; VALINE;

EID: 33845741171     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328011592c     Document Type: Article

References (19)

1. Fumagalli F, Racagni G, Riva MA. The expanding role of BDNF: a therapeutic target for Alzheimer's disease? Pharmacogenomics J 2006; 6:8-15.
2. Woo NH, Lu B. Regulation of cortical interneurons by neurotrophins: from development to cognitive disorders. Neuroscientist 2006; 12:43-56.
3. Shimizu E, Hashimoto K, Iyo M. Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet 2004; 126:122-123.
4. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, et al. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004; 24:4401-4411.
5. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112:257-269.
6. Gorski JA, Balogh SA, Wehner JM, Jones KR. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 2003; 121:341-354.
7. Hashimoto T, Bergen SE, Nguyen QL, Xu B, Monteggia LM, Pierri JN, et al. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 2005; 25:372-383.
8. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, et al. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 1999; 98:739-755.
9. Marty S, Wehrle R, Sotelo C. Neuronal activity and brain-derived neurotrophic factor regulate the density of inhibitory synapses in organotypic slice cultures of postnatal hippocampus. J Neurosci 2000; 20:8087-8095.
10. Marty S, Berninger B, Carroll P, Thoenen H. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron 1996; 16:565-570.
11. Rutherford LC, DeWan A, Lauer HM, Turrigiano GG. Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures. J Neurosci 1997; 17:4527-4535.
12. Kaufman DL, Houser CR, Tobin AJ. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem 1991; 56:720-723.
13. Ohba S, Ikeda T, Ikegaya Y, Nishiyama N, Matsuki N, Yamada MK. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cereb Cortex 2005; 15:291-298.
14. Yamada MK, Nakanishi K, Ohba S, Nakamura T, Ikegaya Y, Nishiyama N, et al. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J Neurosci 2002; 22:7580-7585.
15. Somogyi P, Klausberger T. Defined types of cortical interneurone structure space and spike timing in the hippocampus. J Physiol 2005; 562:9-26.
16. Hashimoto T, Lewis DA. BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 2006; 163:534-537.
17. Rybakowski JK, Borkowska A, Skibinska M, Szczepankiewicz A, Kapelski P, Leszczynska-Rodziewicz A, et al. Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin Neurosci 2006; 60:70-76.
18. Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G, et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 2002; 7:579-593.
19. Lee JL, Everitt BJ, Thomas KL. Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 2004; 304:839-843.