Use of calcium channel blockers after stroke is not associated with poor outcome: A cohort from the registry of the Canadian stroke network

Journal of Neurology

Volumn 253, Issue 11, 2006, Pages 1478-1483

  Dowlatshahi, Dar ^a   Fang, Jiming ^b   Kawaja, Marc ^c   Hakim, Antoine ^d  

^a UNIVERSITY OF OTTAWA   (Canada)

^b INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Calcium channel blockers; Mortality; Recovery; Stroke; Treatment

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; DRUG SAFETY; FEMALE; FUNCTIONAL ASSESSMENT; HOSPITAL DISCHARGE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PATIENT INFORMATION; PRIORITY JOURNAL; RATING SCALE; REGISTER; TREATMENT DURATION; TREATMENT OUTCOME;

AGED; CALCIUM CHANNEL BLOCKERS; CANADA; CEREBROVASCULAR ACCIDENT; COHORT STUDIES; FEMALE; HUMANS; HYPERTENSION; MALE; RECOVERY OF FUNCTION; RECURRENCE; REGISTRIES; SURVIVAL RATE;

EID: 33845681685     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-006-0249-1     Document Type: Article

References (24)

1. Ahmed N, Nasman P, Wahlgren NG. (2000) Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. Stroke 31:1250-1255
2. Angeli F, Verdecchia P, Reboldi GP, Gattobigio R, Bentivoglio M, Staessen JA, Porcellati C. (2004) Calcium channel blockade to prevent stroke in hypertension: a meta-analysis of 13 studies with 103,793 subjects. Am J Hypertens 17:817-822
3. Ciccolini F, Collins TJ, Sudhoelter J, Lipp P, Berridge MJ, Bootman MD (2003) Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation. J Neurosci 23:103-111
4. Dahlof B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester PO. (1991) Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 338:1281-1285
5. Davis SM, Lees KR, Albers GW, Diener HC, Markabi S, Karlsson G, Norris J. (2000) Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke 31:347-354
6. Diener HC, AlKhedr A, Busse O, Hacke W, Zingmark PH, Jonsson N, Basun H. (2002) Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study. J Neurol 249:561-568
7. Duncan PW, Lai SM, Bode RK, Perera S, DeRosa J. (2003) Stroke Impact Scale-16: A brief assessment of physical function. Neurology 60:291-296
8. Duncan PW, Lai SM, Tyler D, Perera S, Reker DM, Studenski S. (2002) Evaluation of proxy responses to the Stroke Impact Scale. Stroke 33:2593-2599
9. Edwards B, O'Connell B. (2003) Internal consistency and validity of the Stroke Impact Scale 2.0 (SIS 2.0) and SIS-16 in an Australian sample. Qual Life Res 12:1127-1135
10. Gueyffier F, Boissel JP, Boutitie F, Pocock S, Coope J, Cutler J, Ekbom T, Fagard R, Friedman L, Kerlikowske K, Perry M, Prineas R, Schron E. (1997) Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. The INDANA (INdividual Data ANalysis of Antihypertensive intervention trials) Project Collaborators. Stroke 28:2557-2562
11. Hardingham GE, Fukunaga Y, Bading H. (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414
12. Horn J, de Haan RJ, Vermeulen M, Limburg M. (2001) Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial. Stroke 32:461-465
13. Horn, J. and Limburg, M. (2000) Calcium antagonists for acute ischemic stroke. Cochrane.Database.Syst.Rev. CD001928-
14. Lai SM, Perera S, Duncan PW, Bode R. (2003) Physical and social functioning after stroke: comparison of the Stroke Impact Scale and Short Form-36. Stroke 34:488-493
15. Medical Research Working Party (1985) MRC trial of treatment of mild hypertension: principal results. BMJ (Clin Res Ed) 291:97-104
16. MRC Working Party (1992) Medical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 304:405-412
17. Pisani A, Calabresi P, Tozzi A, D'Angelo V, Bernardi G. (1998) L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons. Stroke 29:196-201
18. SHEP Cooperative Research Group (1991) Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 265:3255-3264
19. Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, O'Brien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A. (1997) Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 350:757-764
20. Steen PA, Gisvold SE, Milde JH, Newberg LA, Scheithauer BW, Lanier WL, Michenfelder JD. (1985) Nimodipine improves outcome when given after complete cerebral ischemia in primates. Anesthesiology 62:406-414
21. The American Nimodipine Study Group (1992) Clinical trial of nimodipine in acute ischemic stroke. Stroke 23:3-8
22. Trust Study Group (1990) Randomised, double-blind, placebo-controlled trial of nimodipine in acute stroke. Lancet 336:1205-1209
23. Tu JV, Willison DJ, Silver FL, Fang J, Richards JA, Laupacis A, Kapral MK. (2004) Impracticability of informed consent in the Registry of the Canadian Stroke Network. N Engl J Med 350:1414-1421
24. Uematsu D, Greenberg JH, Reivich M, Hickey WF. (1989) Direct evidence for calcium-induced ischemic and reperfusion injury. Ann Neurol 26:280-283