Why Escherichia coli α-hemolysin induces calcium oscillations in mammalian cells - The pore is on its own

FASEB Journal

Volumn 20, Issue 7, 2006, Pages

  Koschinski, Andreas ^a   Repp, Holger ^a   Ünver, Baris ^a   Dreyer, Florian ^a   Brockmeier, Dierk ^a   Valeva, Angela ^b   Bhakdi, Sucharit ^b   Walev, Iwan ^b  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Gram negative bacteria; Membrane lesions; Pore forming toxins; RTX toxins

Indexed keywords

ALPHA HEMOLYSIN; CALCIUM; CALCIUM CHANNEL; HEMOLYSIN; IODINE; NIFEDIPINE; CALCIUM CHANNEL BLOCKING AGENT; ESCHERICHIA COLI PROTEIN; HLYE PROTEIN, E COLI;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CONTROLLED STUDY; ENDOTHELIUM CELL; ESCHERICHIA COLI; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY CELL; PATCH CLAMP; PRIORITY JOURNAL; CELL LINE; CYTOLOGY; DRUG EFFECT; KIDNEY; METABOLISM; VASCULAR ENDOTHELIUM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA;

CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL LINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEMOLYSIN PROTEINS; HUMANS; KIDNEY; NIFEDIPINE;

EID: 33845676576     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4561fje     Document Type: Article

References (25)

1. Stanley, P., Koronakis, V., and Hughes, C. (1998) Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function. Microbiol. Mol. Biol. Rev. 62, 309-333
2. Welch, R.A. (2001) RTX toxin structure and function: a story of numerous anomalies and few analogies in toxin biology. In Pore-Forming Toxins (van der Goot, G.F., ed.) pp. 85-112, Springer Verlag, Berlin, Germany
3. Hyland, C., Vuillard, L., Hughes, C., and Koronakis, V. (2001) Membrane interaction of Escherichia coli hemolysin: flotation and insertion-dependent labelling by phospholipids vesicles. J. Bacteriol. 183, 5364-5370
4. Schindel, C., Zitzer, A., Schulte, B., Gerhards, A., Stanley, P., Hughes, C., et al. (2001) Interaction of Escherichia coli hemolysin with biological membranes. A study using cysteine scanning mutagenesis. Eur. J. Biochem. 268, 800-808
5. Lally, E.T., Kieba, I.R., Sato, A., Green, C.L., Rosenbloom, J. Korostoff, J., Wang, J.F., Shenker, B.J., Ortlepp, Robinson, M. K., and Billings, P. C. (1997) RTX toxins recognize an β2 integrin on the surface of human target cells. J. Biol. Chem. 272, 30463-30469
6. Cortajarena, A.L., Goni, F. M., and Ostolaza, H. (2001) Glycophorin as a receptor for Escherichia coli alpha-hemolysin in erythrocytes. J. Biol. Chem. 276, 12513-12519
7. Benz, R., Schmid, A., Wagner, and Goebel, W. (1989) Pore formation by the Escherichia coli hemolysin: evidence for an association-dissociation equilibrium of the pore-forming aggregates. Infect. Immun. 57, 887-895
8. Menestrina, G., Pederzolli, C., Dalla Serra, M., Bregante, J., and Gambale, F. (1996) Permeability increase induced by Escherichia coli hemolysin A in human macrophages is due to the formation of ionic pores: a patch clamp characterization. J. Membr. Biol. 149, 113-121
9. Menestrina, G., Mackman, N., Holland, I. B., and Bhakdi, S. (1987) Escherichia coli haemolysin forms voltage-dependent ion channels in lipid membranes. Biochim. Biophys. Acta 905, 109-117
10. Bhakdi, S., Walev, I., Jonas, D., Palmer, M., Weller, U., Suttorp, et al. (1996) Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins. Curr. Top. Microbiol. Immunol. 216, 101-118
11. Valeva, A., Walev, I., Gerber, A., Klein, J., Palmer, M., and Bhakdi, S. (2000) Staphylococcal alpha-toxin: repair of a calcium permeable pore in the target cell membrane. Mol. Microbiol. 36, 467-476
12. Walev, I., Bhakdi, S. C., Hofmann, F., Djonder, N., Valeva, A., Aktories, K., and Bhakdi, S. (2001) Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc. Natl. Acad. Sci. U. S. A. 98, 3185-3190
13. Dragneva, Y., Anuradha, C. D., Valeva, A., Hoffmann, A., Bhakdi, S., and Husmann, M. (2001) Subcytocidal attack by staphylococcal alpha-toxin activates Nf-kappaB and induces interleukin-8 production. Infect. Immun. 69, 2630-2635
14. Walev, I., Hombach, M., Bobkiewicz, W., Fenske, D., Bhakdi, S., and Husmann, M. (2002) Resealing of large transmembrane pores produced by streptolysin O in nucleated cells is accompanied by NF-kappaB activation and downstream events. FASEB J. 216, 237-239
15. Berridge, J. J., Bootman, M. D., and Roderick, H. L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell. Biol. 4, 517-529
16. Lewis, R. S. (2003) Calcium oscillation in T-cells: mechanisms and consequence for gene expression. Biochem. Soc. Trans. 31, 925-929
17. 2+ oscillations in renal epithelial cells. Nature 405, 694-697
18. 2+ oscillations. Cell Microbiol. 4, 483-491
19. Koschinski, A., Wengler, G., Wengler, G., and Repp, H. (2003) The membrane proteins of flaviviruses form ion-permeable pores in the target membrane after fusion: Identification of the pores and analysis of their possible role in virus infection. J. Gen. Virol. 84, 1711-1721
20. Berjukow, S., Doring, F., Froschmayr, M., Grabner, M., Glossmann, H., and Hering, S. (1996) Endogenous calcium channels in human embryonic kidney (HEK293) cells. Br J. Pharmacol. 118, 748-754
21. 2+ channel diversity: is it time for T? J. Membr. Biol. 161, 207-213
22. Rink, T. J. (1990) Receptor-mediated calcium entry. FEBS Lett. 268, 381-385
23. De Vries, H., and Beijersbergen van Henegouwen, G. M. (1998) Photoreactivity of nifedipine in vitro and in vivo. J. Photochem. Photobiol. B 43, 217-221
24. 2+ channels. Biochem. Pharmacol. 61, 1161-1167
25. Savigni, D.L., Wege, D., Cliff, G.S., Meesters, M. L., and Morgan, E. H. (2003) Iron and transition metal transport into erythrocytes mediated by nifedipine degradation products and related compounds. Biochem. Pharmacol. 65, 1215-1226