Analysis of 927T > C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma

Journal of Investigational Allergology and Clinical Immunology

Volumn 16, Issue 6, 2006, Pages 331-337

  Sanz, C ^a   Isidro Garcia M ^b   Dávila González, Ignacio ^a   Moreno, E ^a   Laffond, E ^a   Lorente, F ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Asthma; CYSLT; Gene; Leukotrienes; LTC4; Polymorphism

Indexed keywords

MEMBRANE RECEPTOR; PEPTIDOLEUKOTRIENE; PROTEIN CYSLTR 1; PROTEIN CYSLTR 2;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE SEQUENCE; GENOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MONTE CARLO METHOD; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRICK TEST; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN TEST; SPAIN;

ADOLESCENT; ADULT; ASTHMA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOTRIENES; MALE; MEMBRANE PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEUKOTRIENE; SEX FACTORS; SPAIN;

EID: 33845654271     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Drazen JM, Austen KF. Leukotrienes and airway responses. Am Rev Respir Dis. 1987;136(4):985-98.
2. Hay DW, Torphy TJ, Undem, BJ. Cysteinyl leukotrienes in asthma: old mediators up to new tricks. Trends Pharmacol Sci. 1995;16(9):304-9.
3. Horwitz RJ, McGill KA, Busse WW. The role of leukotriene modifiers in the treatment of asthma. Am J Respir Crit Care Med. 1998;157(Pt 1):1363-71.
4. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science. 1983;220:568-575.
5. Samuelsson B. Leukotrienes: a new class of mediators of immediate hypersensitivity reactions and inflammation. Adv Prostaglandin Thromboxane Leukot Res. 1983;11:1-13.
6. Lam BK. Leukotriene C4 synthase: a critical enzyme for the biosynthesis of SRS-A. Front Biosci. 1997;2:d380-6.:d380-d386.
7. Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci. 1994;91(16):7663-67.
8. Lam BK, Owen WF Jr., Austen KF, Soberman RJ. The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils. J Biol Chem. 1989;264(22):12885-89.
9. Lam BK, Wong PY. Phospholipase A2 (PLA2) release leukotrienes and other lipoxygenase products from endogenous sources. Adv Prostaglandin Thromboxane Leukot Res. 1989;19:598-601:598-601.
10. Anderson ME, Allison RD, Meister A. Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci. 1982;79(4):1088-91.
11. Lee CW, Lewis RA, Corey EJ, Austen KF. Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes. Immunology. 1983;48(1):27-35.
12. Sanak M, Levy BD, Clish CB, Chiang N, Gronert K, Mastalerz L, Serhan CN, Szczeklik A. Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J. 2000;16(1):44-9.
13. Sampson AP, Siddiqui S, Buchanan D, Howarth PH, Holgate ST, Holloway JW, Sayers I. Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax. 2000;55(Suppl 2):S28-31.:S28-S31.
14. Sayers I, Sampson AP, Ye S, Holgate ST. Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene. Eur J Hum Genet. 2003;11(8):619-22.
15. Sayers I, Barton S, Rorke S, Beghe B, Hayward B, Van Eerdewegh P, Keith T, Clough JB, Ye S, Holloway JW, Sampson AP, Holgate ST. Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. Thorax. 2003;58(5):417-24.
16. Coleman RA, Eglen RM, Jones RL, Narumiya S, Shimizu T, Smith WL, Dahlen SE, Drazen JM, Gardiner PJ, Jackson WT. Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:283-5.
17. Labat C, Ortiz JL, Norel X, Gorenne I, Verley J, Abram TS, Cuthbert NJ, Tudhope SR, Norman P, Gardiner P. A second cysteinyl leukotriene receptor in human lung. J Pharmacol Exp Ther. 1992;263(2):800-5.
18. Leff JA. Leukotriene modifiers as novel therapeutics in asthma. Clin Exp Allergy. 1998;28 (Suppl 5):147-53; discussion 171-3:147-53.
19. Suissa S, Dennis R, Ernst P, Sheehy O, Wood-Dauphinee S. Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1997;126(3):177-83.
20. Grossman J. One airway, one disease. Chest. 1997;11 (Suppl 2):11S-16S.
21. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr., Ford-Hutchinson AW, Caskey CT, Evans JF. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999;399(6378):789-93.
22. Hui Y, Funk CD. Cysteinyl leukotriene receptors. Biochem Pharmacol. 2002;64(11):1549-57.
23. Henderson WR Jr. The role of leukotrienes in inflammation. Ann Intern Med. 1994;121(9):684-97.
24. Henderson WR Jr. Role of leukotrienes in asthma. Ann Allergy. 1994;72(3):272-8.
25. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152:77-121.
26. Isidoro-Garcia M, Davila I, Laffond E, Moreno E, Lorente F, Gonzalez-Sarmiento R. Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. Clin Mol Allergy. 2005;3:15.
27. Position paper: Immunotherapy with hymenoptera venoms. (EAACI) The European Academy of Allergology and Clinical Immunology Allergy 1993, 48(14 Suppl):36-46.
28. Fleiss JL. Statistical Methods for Rates and Proportions. In: John Wiley and Sons.New York, editor. 1981.
29. Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96(6):434-42.
30. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;5(2):97-8.
31. Choi JH, Park HS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Hum Genet. 2004;114(4):337-44.
32. Bigby TD, Hodulik CR, Arden KC, Fu L. Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35. Mol Med. 1996;2(5):637-46.
33. Sanak M, Sampson AP. Biosynthesis of cysteinyl-leucotrienes in aspirin-intolerant asthma. Clin Exp Allergy. 1999;29(3):306-13.
34. Van Sambeek R, Stevenson DD, Baldasaro M, Lam BK, Zhao J, Yoshida S, Yandora C, Drazen JM, Penrose JF. 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol. 2000;106 (Pt 1):72-6.
35. Isidoro-Garcia M, Davila I, Moreno E, Lorente F, Gonzalez-Sarmiento R. Analysis of the leukotriene C4 synthase A-444C promoter polymorphism in a Spanish population. J Allergy Clin Immunol. 2005;115(1):206-7.
36. Kawagishi Y, Mita H, Taniguchi M, Maruyama M, Oosaki R, Higashi N, Kashii T, Kobayashi M, Akiyama K. Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. J Allergy Clin Immunol. 2002;109(6):936-42.
37. Cookson, W, Moffatt M. Making sense of asthma genes. N Engl J Med. 2004;351(17):1794-6.
38. Horwood LJ, Fergusson DM, Shannon FT. Social and familial factors in the development of early childhood asthma. Pediatrics. 1985;75(5):859-68.
39. Schachter EN, Doyle CA, Beck GJ. A prospective study of asthma in a rural community. Chest. 1984;85(5):623-30.
40. Colhoun HM, McKeigue PM, Davey SG. Problems of reporting genetic associations with complex outcomes. Lancet. 2003;361(9360):865-72.
41. Gomes I, Collins A, Lonjou C, Thomas NS, Wilkinson J, Watson M, Morton N. Hardy-Weinberg quality control. Ann Hum Genet. 1999;63(Pt 6):535-8.
42. Xu J, Turner A, Little J, Bleecker ER, Meyers DA. Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? Hum Genet. 2002;111(6):573-4.