From marrow oedema to osteonecrosis: Common paths in the development of post-transplant bone pain

Nephrology

Volumn 11, Issue 6, 2006, Pages 560-567

  Elder, Grahame J ^a,b  

^a WESTMEAD HOSPITAL   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

Bone pain; Calcineurin inhibitors; Glucocorticoid; Marrow oedema; Osteonecrosis; Transplantation

Indexed keywords

ALENDRONIC ACID; ANTILIPEMIC AGENT; ATORVASTATIN; AZATHIOPRINE; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN; CALCINEURIN INHIBITOR; CALCIUM CHANNEL BLOCKING AGENT; CLOFIBRATE; CYCLOSPORIN; CYCLOSPORIN A; DIHYDROPYRIDINE DERIVATIVE; GLUCOCORTICOID; IBANDRONIC ACID; ILOPROST; IMMUNOSUPPRESSIVE AGENT; LIPID; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METHYLPREDNISOLONE; MEVINOLIN; NIFEDIPINE; NONSTEROID ANTIINFLAMMATORY AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PREDNISOLONE; RAPAMYCIN; STEROID; TACROLIMUS; VITAMIN D;

ADIPOCYTE; AFRICAN AMERICAN; ANALGESIA; APOPTOSIS; AUTOIMMUNE DISEASE; BLOOD FLOW; BODY WEIGHT; BONE COMPARTMENT SYNDROME; BONE MARROW; BONE MARROW EDEMA; BONE NECROSIS; BONE PAIN; BONE TRANSPLANTATION; CALCINEURIN INHIBITOR INDUCED BONE PAIN SYNDROME; CALCINEURIN INHIBITOR INDUCED PAIN SYNDROME; CELL DIFFERENTIATION; CHEMOPROPHYLAXIS; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CORTICOSTEROID INDUCED OSTEOPOROSIS; DECOMPRESSION SURGERY; DISEASE ACTIVITY; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; EDEMA; EXTRACORPOREAL LITHOTRIPSY; HLA MATCHING; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY PERFUSION; KIDNEY TRANSPLANTATION; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RACE DIFFERENCE; RADIODIAGNOSIS; REVIEW; RISK FACTOR; SCINTISCANNING; SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; TOTAL HIP PROSTHESIS; TRABECULAR BONE; TREATMENT OUTCOME; VASCULARIZATION; VASOCONSTRICTION;

BONE MARROW; EDEMA; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; OSTEONECROSIS; PAIN, POSTOPERATIVE;

EID: 33845635602     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2006.00708.x     Document Type: Review

References (57)

1. Sperschneider H, Stein G. Bone disease after renal transplantation. Nephrol. Dial. Transplant. 2003; 18: 874-7.
2. Tang S, Chan TM, Lui SL et al. Risk factors for avascular bone necrosis after renal transplantation. Transplant. Proc. 2000; 32: 1873-5.
3. Han D, Kim S, Chang J. Avascular necrosis following renal transplantation. Transplant. Proc. 1998; 30: 3034-5.
4. Braun WE, Richmond BJ, Protiva DA et al. The incidence and management of osteoporosis, gout, and avascular necrosis in recipients of renal allografts functioning more than 20 years (level 5A) treated with prednisone and azathioprine. Transplant. Proc. 1999; 31: 1366-9.
5. Inoue S, Horii M, Asano T et al. Risk factors for nontraumatic osteonecrosis of the femoral head after renal transplantation. J. Orthop. Sci. 2003; 8: 751-6.
6. Abbott KC, Oglesby RJ, Agodoa LY. Hospitalized avascular necrosis after renal transplantation in the United States. Kidney Int. 2002; 62: 2250-56.
7. Ficat P, Arlet J (eds). Ischemie et Necrose Osseuses. Paris: Masson Edit, 1977; 122-224.
8. Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J. Bone Joint Surg. Br. 1985; 67: 3-9.
9. Plakseychuk AY, Shah M, Varitimidis SE et al. Classification of osteonecrosis of the femoral head. Reliability, reproducibility, and prognostic value. Clin. Orthop. Relat. Res. 2001; 386: 34-41.
10. Plenk H Jr, Gstettner M, Grossschmidt K et al. Magnetic resonance imaging and histology of repair in femoral head osteonecrosis. Clin. Orthop. Relat. Res. 2001; 386: 42-53.
11. Ryu JS, Kim JS, Moon DH et al. Bone SPECT is more sensitive than MRI in the detection of early osteonecrosis of the femoral head after renal transplantation. J. Nucl. Med. 2002; 43: 1006-11.
12. Lamer S, Dorgeret S, Khairouni A et al. Femoral head vascularisation in Legg-Calve-Perthes disease: Comparison of dynamic gadolinium-enhanced subtraction MRI with bone scintigraphy. Pediatr. Radiol. 2002; 32: 580-85.
13. Tsuji T, Sugano N, Sakai T et al. Evaluation of femoral perfusion in a non-traumatic rabbit osteonecrosis model with T2*-weighted dynamic MRI. J. Orthop. Res. 2003; 21: 341-51.
14. Grotz WH, Breitenfeldt MK, Braune SW et al. Calcineurin-inhibitor induced pain syndrome (CIPS): A severe disabling complication after organ transplantation. Transpl. Int. 2001; 14: 16-23.
15. Gauthier VJ, Barbosa LM. Bone pain in transplant recipients responsive to calcium channel blockers. Ann. Intern. Med. 1994; 121: 863-5.
16. Coates PT, Tie M, Russ GR et al. Transient bone marrow edema in renal transplantation: A distinct post-transplantation syndrome with a characteristic MRI appearance. Am. J. Transplant. 2002; 2: 467-70.
17. Pilmore H, Walker R, McMillan B et al. Acute bone pain following renal transplantation: Differentiation between benign bone edema and avascular necrosis. Am. J. Nephrol. 1998; 18: 57-60.
18. Beresford JN, Bennett JH, Devlin C et al. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 1992; 102: 341-51.
19. Wang GJ, Cui Q, Balian G. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin. Orthop. Relat. Res. 2000; 370: 295-310.
20. Cui Q, Wang GJ, Balian G. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. J. Bone Joint Surg. Am. 1997; 79: 1054-63.
21. Cui Q, Wang GJ, Balian G. Pluripotential marrow cells produce adipocytes when transplanted into steroid-treated mice. Connect. Tissue Res. 2000; 41: 45-56.
22. Bennett CN, Ross SE, Longo KA et al. Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 2002; 277: 30998-1004.
23. Miyanishi K, Yamamoto T, Irisa T et al. Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis. Bone 2002; 30: 185-90.
24. Motomura G, Yamamoto T, Miyanishi K et al. Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis - a histomorphometric study of autopsy cases. Pathol. Res. Pract. 2005; 200: 807-11.
25. Kim SW, Her SJ, Kim SY et al. Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts. Biochem. Biophys. Res. Commun. 2005; 327: 811-19.
26. Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J. Clin. Endocrinol. Metab. 2000; 85: 2907-12.
27. Sakai T, Sugano N, Kokado Y et al. Tacrolimus may be associated with lower osteonecrosis rates after renal transplantation. Clin. Orthop. Relat. Res. 2003; 415: 163-70.
28. McCune TR, Thacker LRII, Peters TG et al. Effects of tacrolimus on hyperlipidemia after successful renal transplantation: A Southeastern Organ Procurement Foundation multicenter clinical study. Transplantation 1998; 65: 87-92.
29. Nankivell BJ, Chapman JR, Bonovas G et al. Oral cyclosporine but not tacrolimus reduces renal transplant blood flow. Transplantation 2004; 77: 1457-9.
30. Zizic TM, Marcoux C, Hungerford DS et al. The early diagnosis of ischemic necrosis of bone. Arthritis Rheum. 1986; 29: 1177-86.
31. Data on file; 0468E1-301-US, CSR-40491, 2000 and 0468E1-302-GL, CSR-41431, 2001. Wyeth Pharmaceuticals.
32. Kim SY, Koo KH, Suh KT et al. Fatty marrow conversion of the proximal femoral metaphysis in transient bone marrow edema syndrome. Arch. Orthop. Trauma Surg. 2005; 125: 390-95.
33. Vande Berg BC, Malghem J, Lecouvet FE et al. Fat conversion of femoral marrow in glucocorticoid-treated patients: A cross-sectional and longitudinal study with magnetic resonance imaging. Arthritis Rheum. 1999; 42: 1405-11.
34. Vande Berg BC, Gilon R, Malghem J et al. Correlation between baseline femoral neck marrow status and the development of femoral head osteonecrosis in corticosteroid-treated patients: A longitudinal study by MR imaging. Eur. J. Radiol. 2006; 58: 444-9.
35. Stulberg BN, Davis AW, Bauer TW et al. Osteonecrosis of the femoral head. A prospective randomized treatment protocol. Clin. Orthop. Relat. Res. 1991; 268: 140-51.
36. Koo KH, Kim R, Ko GH et al. Preventing collapse in early osteonecrosis of the femoral head. A randomised clinical trial of core decompression. J. Bone Joint Surg. Br. 1995; 77: 870-74.
37. Li X, Cui Q, Kao C et al. Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures. Bone 2003; 33: 652-9.
38. Wang CJ, Wang FS, Huang CC et al. Treatment for osteonecrosis of the femoral head: Comparison of extracorporeal shock waves with core decompression and bone-grafting. J. Bone Joint Surg. Am. 2005; 87: 2380-87.
39. Mont MA, Carbone JJ, Fairbank AC. Core decompression versus nonoperative management for osteonecrosis of the hip. Clin. Orthop. Relat. Res. 1996; 324: 169-78.
40. Castro FP Jr, Barrack RL. Core decompression and conservative treatment for avascular necrosis of the femoral head: A meta-analysis. Am. J. Orthop. 2000; 29: 187-94.
41. Bozic KJ, Zurakowski D, Thornhill TS. Survivorship analysis of hips treated with core decompression for nontraumatic osteonecrosis of the femoral head. J. Bone Joint Surg. Am. 1999; 81: 200-9.
42. Steinberg ME, Larcom PG, Strafford B et al. Core decompression with bone grafting for osteonecrosis of the femoral head. Clin. Orthop. Relat. Res. 2001; 386: 71-8.
43. Kim SY, Kim YG, Kim PT et al. Vascularized compared with nonvascularized fibular grafts for large osteonecrotic lesions of the femoral head. J. Bone Joint Surg. Am. 2005; 87: 2012-18.
44. Fukui N, Kurosawa H, Kawakami A et al. Iliac bone graft for steroid-associated osteonecrosis of the femoral condyle. Clin. Orthop. Relat. Res. 2002; 401: 185-93.
45. Zhao D, Xu D, Wang W et al. Iliac graft vascularization for femoral head osteonecrosis. Clin. Orthop. Relat. Res. 2006; 442: 171-9.
46. Hernigou P, Poignard A, Manicom O et al. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J. Bone Joint Surg. Br. 2005; 87: 896-902.
47. Lieberman JR, Conduah A, Urist MR. Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein. Clin. Orthop. Relat. Res. 2004; 429: 139-45.
48. Stromboni M, Menguy F, Hardy P et al. Total hip arthroplasty and femoral head osteonecrosis in renal transplant recipients. Rev. Chir. Orthop. Reparatrice Appar. Mot. 2002; 88: 467-74.
49. Wang GJ, Rawles JG, Hubbard SL et al. Steroid-induced femoral head pressure changes and their response to lipid-clearing agents. Clin. Orthop. Relat. Res. 1983; 174: 298-302.
50. Pritchett JW. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin. Orthop. Relat. Res. 2001; 386: 173-8.
51. Cui Q, Wang GJ, Su CC et al. The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin. Orthop. Relat. Res. 1997; 344: 8-19.
52. Belmont HM, Lydon E. Avascular necrosis prevention with lipitor in lupus erythematosus. Lupus 2005; 14: 869-70.
53. Kim HK, Randall TS, Bian H et al. Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs. J. Bone Joint Surg. Am. 2005; 87: 550-7.
54. Morgan-Bagley S, Kostenuik P, Kim HK. RANKL inhibition decreases femoral head deformity following ischemic necrosis of the femoral head in immature pigs. J. Bone Miner. Res. 2005; 20 (Suppl. 1): S33, abstract 1128.
55. Lai KA, Shen WJ, Yang CY et al. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J. Bone Joint Surg. Am. 2005; 87: 2155-9.
56. Disch AC, Matziolis G, Perka C. The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J. Bone Joint Surg. Br. 2005; 87: 560-64.
57. Laroche M, Jacquemier JM, Montane de la Roque P et al. Nifedipine per os relieves the pain caused by osteonecrosis of the femur head. Rev. Rhum. Mal. Osteoartic 1990; 57: 669-70.