Effects of a novel tripeptide on neurological outcomes after spinal cord injury

NeuroReport

Volumn 17, Issue 17, 2006, Pages 1793-1796

  John, Sunil M ^a   Bao, Feng ^a   Chen, Yuhua ^a   Mathison, Ronald D ^b   Weaver, Lynne C ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Adhesionmolecule; Extravasation; Hind limb paralysis; Inflammation; Mechanical allodynia; Submandibular gland peptide T

Indexed keywords

PHENYLALANYLGLUTAMYLGLYCINE; TRIPEPTIDE DERIVATIVE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; LEUKOCYTE; LOCOMOTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; TREATMENT OUTCOME;

ANIMALS; AVOIDANCE LEARNING; DISEASE MODELS, ANIMAL; MALE; MOTOR ACTIVITY; NEUROLOGIC EXAMINATION; NEUROPEPTIDES; OLIGOPEPTIDES; PHYSICAL STIMULATION; RATS; RATS, WISTAR; SENSORY THRESHOLDS; SPINAL CORD INJURIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 33845632525     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000239963.83566.bb     Document Type: Article

References (24)

1. Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 1991; 75:15-26.
2. Bao F, Liu D. Hydroxyl radicals generated in the rat spinal cord at the level produced by impact injury induce cell death by necrosis and apoptosis: protection by a metalloporphyrin. Neuroscience 2004; 126:285-295.
3. Ramer MS, Harper GP, Bradbury EJ. Progress in spinal cord research: a refined strategy for the International Spinal Research Trust. Spinal Cord 2000; 38:449-472.
4. Casha S, Yu WR, Fehlings MG. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and P75 expression following spinal cord injury. Neuroscience 2001; 103:203-218.
5. Mabon PJ, Weaver LC, Dekaban GA. Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment. Exp Neurol 2000; 166:52-64.
6. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, et al. Role of neutrophils in spinal cord injury in the rat. Neuroscience 1997; 79:1177-1182.
7. Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Ann Rev Immunol 1993; 11:767-804.
8. Harlan JM. Consequences of leukocyte-vessel wall interactions in inflammatory and immune reactions. Semin Thromb Hemost 1987; 13:434-444.
9. Mathison RD, Befus AD, Davison JS, Woodman RC. Modulation of neutrophil function by the tripeptide feG. BMC Immunol 2003; 4:3.
10. Dery RE, Ulanova M, Puttagunta L, Stenton GR, James D, Merani S, et al. Frontline: inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro-endocrine pathway. Eur J Immunol 2004; 34:3315-3325.
11. Bao F, John SM, Chen Y, Mathison RD, Weaver LC. The tripeptide feG modulates leukocyte infiltration and oxidative damage in rat injured spinal cord. Neuroscience 2006; 140:1011-1022.
12. Bruce JC, Oatway MA, Weaver LC. Chronic pain after clip compression injury of the rat spinal cord. Exp Neurol 2002; 178:33-48.
13. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12:1-21.
14. Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, et al. Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. J Neurosci 2004; 24:4043-4051.
15. Senn S, Stevens L, Chaturvedi N. Repeated measures in clinical trials: simple strategies for analysis using summary measures. Stat Med 2000; 19:861-877.
16. Fehlings MG, Tator CH. A review of models of acute experimental spinal cord injury. In: Illis LS, editor. Spinal cord dysfunction: assessment. Oxford: Oxford University Press; 1988. pp. 3-33.
17. Fouad K, Pearson K. Restoring walking after spinal cord injury. Prog Neurobiol 2004; 73:107-126.
18. Yezierski RP. Pain following spinal cord injury: the clinical problem and experimental studies. Pain 1996; 68:185-194.
19. Gebhart GF. Descending modulation of pain. Neurosci Biobehav Rev 2004; 27:729-737.
20. Mathison RD, Davison JS, Metwally E. Identification of a binding site for the anti-inflammatory tripeptide feG. Peptides 2003; 24:1221-1230.
21. Mathison RD, Davison JS. The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils. J Inflamm (London) 2006; 3:9.
22. Reeves EP, Dekker LV, Forbes LV, Wientjes FB, Grogan A, Pappin DJ, et al. Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils. Biochem J 1999; 344(Pt 3):859-866.
23. Bey EA, Xu B, Bhattacharjee A, Oldfield CM, Zhao X, Li Q, et al. Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. J Immunol 2004; 173:5730-5738.
24. Min KJ, Pyo HK, Yang MS, Ji KA, Jou I, Joe EH. Gangliosides activate microglia via protein kinase C and NADPH oxidase. Glia 2004; 48: 197-206.