Irreversible inhibition of glucose-6-phosphate dehydrogenase by the coenzyme A conjugate of ketoprofen: A key to oxidative stress induced by non-steroidal anti-inflammatory drugs?

Biochemical Pharmacology

Volumn 73, Issue 3, 2007, Pages 405-416

  Asensio, Carine ^a   Levoin, Nicolas ^a   Guillaume, Cécile ^a   Guerquin, Marie Justine ^a   Rouguieg, Koukeb ^a   Chrétien, Françoise ^b   Chapleur, Yves ^b   Netter, Patrick ^a   Minn, Alain ^a   Lapicque, Françoise ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b NANCY UNIVERSITÉ   (France)

Author keywords

Allosteric site; Chiral NSAID; Coenzyme A metabolite; Digestive side effects; Glucose 6 phosphate dehydrogenase; Oxidative stress

Indexed keywords

ACYL COENZYME A CARBOXYLASE; ARACHIDONIC ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE INHIBITOR; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLYCERALDEHYDE 3 PHOSPHATE; KETOPROFEN COENZYME A; KETOPROFEN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PALMITOYL COENZYME A HYDROLASE; PHOSPHOENOLPYRUVATE; PROPIONIC ACID DERIVATIVE; PROSTAGLANDIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CHIRALITY; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; ENANTIOMER; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CACO-2 CELLS; COENZYME A; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; KETOPROFEN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 33845609248     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.09.026     Document Type: Article

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