Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue

Cancer Gene Therapy

Volumn 14, Issue 1, 2007, Pages 12-18

  Pataer, A ^a,c   Bocangel, D ^a   Chada, S ^b   Roth, J A ^a   Hunt, K K ^c   Swisher, S G ^a  

^a Department of Thoracic and Cardiovascular Surgery ^*  (United States)

^b Introgen Therapeutics Inc   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adenovirus and gene therapy; Apoptosis; mda 7; PKR

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; ADENOVIRUS VECTOR; ANSAMYCIN DERIVATIVE; BENZOQUINONE DERIVATIVE; BETA CATENIN; GELDANAMYCIN; GENE PRODUCT; MELANOMA DIFFERENTIATION ASSOCIATED GENE 7 PROTEIN; MONOCLONAL ANTIBODY; PROTEIN KINASE B; PROTEIN KINASE R; UVOMORULIN;

ARTICLE; CANCER CELL; CANCER CELL DESTRUCTION; CELL LEVEL; CELL MOTILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INDUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; BENZOQUINONES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; HUMANS; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES;

ADENOVIRIDAE;

EID: 33845608618     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700989     Document Type: Article

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