A model genetic system for testing the in vivo function of peptide toxins

Peptides

Volumn 28, Issue 1, 2007, Pages 51-56

  Tedford, Hugo W ^a   Maggio, Francesco ^a   Reenan, Robert A ^a   King, Glenn ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Atracotoxin; Drosophila melanogaster; Peptide toxin; Transgenesis

Indexed keywords

ATRACOTOXIN; CALCIUM CHANNEL; INSECTICIDE; ION CHANNEL; PEPTIDE; PEPTIDE TOXIN; SPIDER VENOM; TOXIN;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL PEST CONTROL; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; FEMALE; GENE EXPRESSION; GENE INDUCTION; GENETIC MODEL; HADRONYCHE VERSUTA; HEATING; IN VIVO STUDY; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SPECIES DIFFERENCE; SPIDER; TOXIN ANALYSIS; TRANSGENE; TRANSGENICS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLACK WIDOW SPIDER; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENETIC VECTORS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PEPTIDES; SEQUENCE ALIGNMENT; SPIDER VENOMS; TOXINS, BIOLOGICAL; TRANSFORMATION, GENETIC;

ANIMALIA; DIPLURIDAE; DROSOPHILA MELANOGASTER; HADRONYCHE VERSUTA; INSECTA;

EID: 33845608483     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.08.026     Document Type: Article

References (31)

1. Bloomquist J.R. Mode of action of atracotoxin at central and peripheral synapses of insects. Invertebr Neurosci 5 (2003) 45-50
2. Cavener D.R. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Res 15 (1987) 1353-1361
3. 1 subunit gene in Drosophila melanogaster. Genetics 148 (1998) 1159-1169
4. Escoubas P., Sollod B.L., and King G.F. Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach. Toxicon 47 (2006) 650-663
5. Fletcher J.I., Smith R., O'Donoghue S.I., Nilges M., Connor M., Howden M.E.H., et al. The structure of a novel insecticidal neurotoxin, ω-atracotoxin-HV1, from the venom of an Australian funnel web spider. Nat Struct Biol 4 (1997) 559-566
6. Greenspan R.J. Fly pushing: the theory and practice of Drosophila genetics (1997), Cold Spring Harbor Laboratory Press, Cold Spring Harbor
7. Kawasaki F., Collins S.C., and Ordway R.W. Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony. J Neurosci 22 (2002) 5856-5864
8. Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 196 (1987) 947-950
9. Lewis R.J., and Garcia M.L. Therapeutic potential of venom peptides. Nat Rev Drug Discov 2 (2003) 790-802
10. Maggio F., and King G.F. Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function. J Biol Chem 277 (2002) 22806-22813
11. Maggio F., Sollod B.L., Tedford H.W., and King G.F. Spider toxins and their potential for insect control. In: Gilbert L.I., Iatrou K., and Gill S.S. (Eds). Comprehensive molecular insect science vol. 5 (2005), Elsevier, Oxford
12. Massey Jr. H.C., Kejzlarova-Lepesant J., Willis R.L., Castleberry A.B., and Benes H. The Drosophila Lsp-1 beta gene. A structural and phylogenetic analysis. Eur J Biochem 245 (1997) 199-207
13. O'Brochta D.A., and Atkinson P.W. Transformation systems in insects. Methods Mol Biol 260 (2004) 227-254
14. Ornitz D.M., Moreadith R.W., and Leder P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc Natl Acad Sci USA 88 (1991) 698-702
15. 2+ channel activation of ryanodine receptors. Neuron 40 (2003) 53-63
16. Park S., and Lim J.K. A microinjection technique for ethanol-treated eggs and a mating scheme for detection of germline transformants. Dros Inf Serv 76 (1995) 197-199
17. Ranson H., Claudianos C., Ortelli F., Abgrall C., Hemingway J., Sharakhova M.V., et al. Evolution of supergene families associated with insecticide resistance. Science 298 (2002) 179-181
18. Robinson A.S., Franz G., and Atkinson P.W. Insect transgenesis and its potential role in agriculture and human health. Insect Biochem Mol Biol 34 (2004) 113-120
19. Rose L.S., and Wieschaus E. The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio. Genes Dev 6 (1992) 1255-1268
20. Schliekelman P., and Gould F. Pest control by the introduction of a conditional lethal trait on multiple loci: potential, limitations, and optimal strategies. J Econ Entomol 93 (2000) 1543-1565
21. Sega G.A. A review of the genetic effects of ethyl methanesulfonate. Mutat Res 134 (1984) 113-142
22. 1 subunit in Drosophila. Genetics 149 (1998) 1407-1426
23. 1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci 16 (1996) 7868-7879
24. Sollod B.L., Wilson D., Zhaxybayeva O., Gogarten J.P., Drinkwater R., and King G.F. Were arachnids the first to use combinatorial peptide libraries?. Peptides 26 (2005) 131-139
25. Tedford H.W., Fletcher J.I., and King G.F. Functional significance of the β-hairpin in the insecticidal neurotoxin ω-atracotoxin-Hv1a. J Biol Chem 276 (2001) 26568-26576
26. Tedford H.W., Gilles N., Ménez A., Doering C.J., Zamponi G.W., and King G.F. Scanning mutagenesis of ω-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against invertebrate calcium channels. J Biol Chem 279 (2004) 44133-44140
27. Tedford H.W., Sollod B.L., Maggio F., and King G.F. Australian funnel-web spiders: master insecticide chemists. Toxicon 43 (2004) 601-618
28. Thummel C.S., Boulet A.M., and Lipshitz H.D. Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene 74 (1988) 445-456
29. Vincent A., Colot H.V., and Rosbash M. Blastoderm-specific and read-through transcription of the sry alpha gene transformed into the Drosophila genome. Dev Biol 118 (1986) 480-487
30. Wang X.-H., Connor M., Smith R., Maciejewski M.W., Howden M.E.H., Nicholson G.M., et al. Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bond. Nat Struct Biol 7 (2000) 505-513
31. Wang X.-H., Smith R., Fletcher J.I., Wilson H., Wood C.J., Howden M.E.H., et al. Structure-function studies of ω-atracotoxin, a potent antagonist of insect voltage-gated calcium channels. Eur J Biochem 264 (1999) 488-494