Does leukodepletion during elective cardiac surgery really influence the overall clinical outcome?

Journal of Cardiovascular Surgery

Volumn 44, Issue 2, 2003, Pages 197-204

  Efstathiou, A ^a   Vlachveis, M ^a   Tsonis, G ^a   Asteri, T ^a   Psarakis, A ^a   Fessatidis, I T ^a  

^a G PAPANICOLAOU HOSPITAL   (Greece)

Author keywords

Cardiopulmonary bypass; Inflammation; Leukocytes

Indexed keywords

ADRENALIN; CATECHOLAMINE; DIURETIC AGENT; VASODILATOR AGENT;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTIVE SURGERY; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; LENGTH OF STAY; LEUKAPHERESIS; LEUKOCYTE COUNT; LEUKOCYTOSIS; MAJOR CLINICAL STUDY; MALE; OXYGENATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; TREATMENT OUTCOME;

CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; ERYTHROCYTE TRANSFUSION; FEMALE; FILTRATION; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; MALE; MIDDLE AGED; PLATELET COUNT; POSTOPERATIVE PERIOD; SURGICAL PROCEDURES, ELECTIVE; TREATMENT OUTCOME;

EID: 0038264387     PISSN: 00219509     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Hashimoto K, Miyamoto H, Suzuki K, Horikoshi S, Matsui M, Arai T et al. Evidence of organ damage after cardiopulmonary bypass. The role of elastase and vasoactive mediators. J Thorac Cardiovasc Surg 1992;104:666-73.
2. Wan S, Le Clerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass. Mechanisms involved and possible therapeutic strategies. Chest 1997;112:676-92.
3. Asimakopoulos G, Taylor KM. Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules. Ann Thorac Surg 1998;66:2135-44.
4. Asimakopoulos G, Kohn A, Stefanou D, Haskard D, Landis R, Taylor KM. Leukocyte integrin expression in patients undergoing cardiopulmonary bypass. Ann Thorac Surg 2000;69:1192-7.
5. Sawa Y, Matsuda H, Shimataki Y, Kaneko M, Nishimura M, Amemiya A et al. Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency coronary artery bypass grafting. J Thorac Cardiovasc Surg 1994;108:1125-31.
6. Gu Y, De Vries A, Boonstra P, Van Oeveren W. Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery. J Thorac Cardiovasc Surg 1996;112:494-500.
7. Gu Y, De Vries A, Bonnstra P, Van Oeveren W. Leukocyte depletion during cardiac operations. A new approach through the venous bypass circuit. Ann Thorac Surg 1999;67:607-9.
8. Palanzo D, Manley N, Montesano R, Yeisley G, Gordon D. Clinical evaluation of the Leuko Guard (LG-6) arterial line filter for routine open-heart surgery. Perfusion 1993;8:489-96.
9. Mihaljevic T, Tonz M, Von Segesser L, Pasic M, Grob P, Fehr J et al. The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function. J Thorac Cardiovasc Surg 1995;109:1138-45.
10. Baksaas S, Videm V, Mollnes T, Tollofsud S, Hetland G, Pedersen D et al. Leukocyte filtration during cardiopulmonary bypass hardly changed leukocyte counts and did not influence myeloperoxidase, compliment, cytokines or platelets. Perfusion 1998;13:429-36.
11. Stefanou D, Gourley D, Asimakopoulos G, Taylor KM. Leukodepletion during cardiopulmonary bypass reduces blood transfusion and crystalloid requirements. Perfusion 2001;16:51-8.
12. Mair P, Hoermann C, Mair J, Margeiter J, Puschendorf B, Balogh D. Effects of a leukocyte depleting arterial line filter on perioperative proteolytic enzyme and oxygen free radical release in patients undergoing aortocoronary bypass surgery. Acta Anqesthesial Scand 1999;43:452-7.
13. Wilcox P, Baile E, Hards J, Müller N, Dunn L, Pardy R et al. Phrenic nerve function and its relationship to atelectasis after coronary artery bypass surgery. Chest 1998;93:693-8.
14. Asimakopoulos G, Smith P, Ratnatunga C, Taylor KM. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass. Ann Thorac Surg 1999;68:1107-15.
15. Dewanjee K, Palatianos N, Kapadvanjwala M, Hsu C, Novak S, Balantino G et al. Neutrophil dynamics and retention in lung, oxygenator, and art filter during cardiopulmonary bypass in a pig model. ASAIO J 1994;40:M547-53.
16. Le Deist F, Menashé P, Kucharski C, Bel A, Piwanica A, Blah G. Hypothermia during cardiopulmonary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Circulation 1995;92 Suppl 2:354-8.
17. Tonz M, Mihaljevic T, Von Segesser L, Fehr J, Schmid E, Turina M. Acute lung injury during cardiopulmonary bypass. Are neutrophils responsible? Chest 1995;108:1551-6.
18. Gourley T, Fleming J, Taylor KM. Laboratory evaluation of the Pall LG6 leukocyte depleting arterial line filter. Perfusion 1992;7:131-40.
19. Gourley T, Fleming J, Taylor KM. The effects of pulsatile flow on the leukocyte depleting qualities of Pall LG6 leukocyte depleting filter: a laboratory investigation. Perfusion 1992;7:227-32.
20. Fabbri A, Manfredi J, Piccin C, Soffiati G, Carta MR, Gasparotto E et al. Systemic leukocyte filtration during cardiopulmonary bypass. Perfusion 2001;16 Suppl:11-8.
21. Saway Y, Taniguchi K, Kadoba K, Nishimura M, Ichikawa H, Amemiya A et al. Leukocyte depletion attenuates reperfusion injury in patients with left ventricular hypertrophy. Circulation 1996;93:1640-6.
22. Ellis SG, Wynne J, Braunwold E, Henschke CI, Sandor T, Kloner RA. Response of reperfusion salvaged stunned myocardium to inotropic stimulation. Am Heart J 1984;107:13-9.
23. Macnaughton D, Braude S, Hunter N, Denison M, Evans W. Changes in lung function and pulmonary capillary permeability after cardiopulmonary bypass. Crit Care Med 1992;20:1289-94.
24. Johnson D, Thomson D, Mycyk T, Burbridge B, Mayers I. Depletion of neutrophils by filter during aortocoronary bypass surgery transiently improves postoperative cardiorespiratory status. Chest 1995;107:1253-9.
25. Thurlow PJ, Doolan L, Sharp R, Sullivan M, Smith B, Andersen LW. Laboratory studies of the effect of pall extracorporeal leukocytes filters LG6 and AV6 on patients undergoing coronary by pass grafts. Perfusion 1996;11:29-37.