Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine

Journal of Immunotoxicology

Volumn 3, Issue 4, 2006, Pages 253-262

  Pruett, Stephen B ^a   Fan, Ruping ^a   Oppenheimer, Seth ^b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Cellular signaling; Immunotoxicity; Macrophage; Mathematical modeling; Pesticide

Indexed keywords

ATRAZINE; CORTICOSTERONE; DIELDRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN C JUN; RIBONUCLEASE; TOLL LIKE RECEPTOR 3; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; CELL CULTURE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; GENE REPRESSION; MACROPHAGE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION INITIATION; UNITED STATES;

ANIMALIA;

EID: 33845476755     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910601069019     Document Type: Conference Paper

References (21)

1. Bernier, J., Hugo, P., Krzystyniak, K., and Fournier, M. 1987. Suppression of humoral immunity in inbred mice by dieldrin. Toxicol. Lett. 35:231-240.
2. Borgert, C. J., Quill, T. F., McCarty, L. S., and Mason, A. M. 2004. Can mode of action predict mixture toxicity for risk assessment? Toxicol. Appl. Pharmacol. 201:85-96.
3. Dewailly, E., Ayotte, P., Bruneau, S., Gingras, S., Belles-Isles, M., and Roy, R. 2000. Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. Environ. Health Perspect. 108:205-211.
4. Donaldson, D., Kiely, T., and Grube, A. 2004. Pesticide Industry Sales and Usage. 1998 and 1999 Market Estimates. OPPT, United States Environmental Protection Agency 2002 [cited 2004]. Available from 〈http://www.epa.gov/ oppbead1/pestsales/〉.
5. Faggioli, L., Costanzo, C., Donadelli, M., and Palmieri, M. 2004. Activation of the interleukin-6 promoter by a dominant negative mutant of c-Jun. Biochim. Biophys. Acta 169:17-24.
6. Filipov, N. M., Pinchuk, L. M., Boyd, B. L., and Crittenden, P. L. 2005. Immunotoxic effects of short-term atrazine exposure in young male C57BL/6 mice. Toxicol. Sci. 86:324-332.
7. Fisher, B. E. 1999. Most unwanted. Environ. Health Perspect. 107:A18-23.
8. Fournier, M., Chevalier, G., Nadeau, D., Trottier, B., and Krzystyniak, K. 1988. Virus-pesticide interactions with murine cellular immunity after sublethal exposure to dieldrin and aminocarb. J. Toxicol. Environ. Health 25:103-118.
9. Jorgenson, J. L. 2001. Aldrin and dieldrin: A review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. Environ. Health Perspect. 109(S1):113-139.
10. Krzystyniak, K., Bernier, J., Hugo, P., and Fournier, M. 1986. Suppression of MHV3 virus-activated macrophages by dieldrin. Biochem. Pharmacol. 35:2577-2586.
11. Mileson, B. E., Chambers, J. E., Chen, W. L., Dettbarn, W., Ehrich, M., Eldefrawi, A. T., Gaylor, D. W., Hamernik, K., Hodgson, E., Karczmar, A. G., Padilla, S., Pope, C. N., Richardson, R. J., Saunders, D. R., Sheets, L. P., Sultatos, L. G., and Wallace, K. B. 1998. Common mechanism of toxicity: A case study of organophosphorus pesticides.Toxicol. Sci. 41:8-20.
12. Oppenheimer, S. F., Kingery, W. L., and Han, F. X. 2001. Phase plane analysis and dynamical systems approaches to the study of metal sorption in soils. In: Sorption/Desorption of Heavy Metals in Soils, eds. H. Salim and D. Sparks, Boca Raton: CRC Press.
13. 1 mice subjected to exogenous corticosterone or to restraint stress. Toxicol. Sci. 49:272-280.
14. Pruett, S. B., Fan, R., and Zheng, Q. 2003a. Characterization of glucocorticoid receptor translocation, cytoplasmic IκB, nuclear NFκB, and activation of NFκB in T-lymphocytes exposed to stress-inducible concentrations of corticosterone in vivo. Int. Immunopharmacol. 3:1-16.
15. Pruett, S. B., Fan, R., Zheng, Q., Myers, L. P., and Hebert, P. 2003b. Modeling and predicting immunological effects of chemical stressors: characterization of a quantitative biomarker for immunological changes caused by atrazine and ethanol. Toxicol. Sci. 75:343-354.
16. Pruett, S. B., Zheng, Q., Schwab, C., and Fan, R. 2005. Sodium methyldithiocarbamate inhibits MAP kinase activation through Toll-like receptor 4, alters cytokine production by mouse peritoneal macrophages, and suppresses innate immunity. Toxicol. Sci. 87:75-85.
17. Pruett, S.B., C. Schwab, Q. Zheng, and R. Fan. 2004. Suppression of innate immunity by ethanol: A global perspective and a new mechanism beginning with inhibition of signaling through Toll-like receptor 3. J. Immunol. 173:2715-2724.
18. USEPA. United States Environmental Protection Agency (2002). 2005a. Toxicological Profile for Aldrin and Dieldrin [cited February 16, 2005]. Available from 〈http://www.atsdr.cdc.gov/toxprofiles/tp1.html 〉.
19. USEPA. United States Environmental Protection Agency (2003). 2005b. Interim Re-registration Eligibility Decision for Atrazine [cited February 16, 2005]. Available from 〈http://www.epa.gov/REDs/atrazine_ired.pdf〉.
20. USGS. United States Geological Survey. 1997. Atrazine Herbicides Estimated Annual Agricultural Use. Available at 〈http://ca.water.usgs.gov/ cgibin/pnsp/pesticide_use_maps_1997.pl?map=W1980〉.
21. Voccia, I., Blakley, B., Brousseau, P., and Fournier, M. 1999. Immunotoxicity of pesticides: A review. Toxicol. Ind. Health 15:119-132.