Menstrual hemocidin HbB115-146 is an acidophilic antibacterial peptide potentiating the activity of human defensins, cathelicidin and lysozyme

American Journal of Reproductive Immunology

Volumn 57, Issue 1, 2007, Pages 81-91

  Mak, Pawel ^a   Siwek, Michal ^a   Pohl, Jan ^b   Dubin, Adam ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha beta defensins; Cathelicidins; Hemoglobin; Lysozyme; Urogenital tract

Indexed keywords

BETA DEFENSIN; BETA GLOBIN; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DEFENSIN; HEMOCIDIN; LYSOZYME; NEUTROPHIL DEFENSIN 1; POLYPEPTIDE ANTIBIOTIC AGENT; RECOMBINANT BETA DEFENSIN 1;

ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; MEMBRANE PERMEABILITY; MENSTRUATION; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ACIDS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CHEMISTRY, PHYSICAL; DEFENSINS; ESCHERICHIA COLI; GLOBINS; HUMANS; HYDROGEN-ION CONCENTRATION; MENSTRUAL CYCLE; MODELS, BIOLOGICAL; MURAMIDASE; PEPTIDE FRAGMENTS;

EID: 33845475257     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2006.00456.x     Document Type: Article

References (40)

1. Mak P, Wójcik K, Silberring J, Dubin A: Antimicrobal peptides from heme-containing proteins: Hemocidins. Antonie van Leeuwenhoek 2000; 77: 197-200.
2. Mak P, Szewczyk A, Mickowska B, Kicińska A, Dubin A: Effect of antimicrobial apomyoglobin 56-131 peptide on liposomes and planar lipid bilayer membrane. Int J Antimicrob Agents 2001; 17: 137-142.
3. Shai Y: Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim Biophys Acta 1999; 1462: 55-70.
4. Froidevaux R, Krier F, Nedjar-Arroume N, Vercaigne-Marko D, Kosciarz E, Ruckebusch C, Dhulster P, Guillochon D: Antibacterial activity of a pepsin-derived bovine hemoglobin fragment. FEBS Lett 2001; 491: 159-163.
5. Parish CA, Jiang H, Tokiwa Y, Berova N, Nakanishi K, McCabe D, Zuckerman W, Xia MM, Gabay JF: Broad-spectrum antimicrobial activity of hemoglobin. Bioorg Med Chem 2001; 9: 377-382.
6. Daoud R, Dubois V, Bors-Dodita L, Nedjar-Arroume N, Krier F, Chihib NE, Mary P, Kouach M, Briand G, Guillochon D: New antibacterial peptide derived from bovine hemoglobin. Peptides 2005; 26: 713-719.
7. Dubois V, Nedjar-Arroume N, Guillochon D: Influence of pH on the appearance of active peptides in the course of peptic hydrolysis of bovine haemoglobin. Prep Biochem Biotechnol 2005; 35: 85-102.
8. Nedjar-Arroume N, Dubois-Delval V, Miloudi K, Daoud R, Krier F, Kouach M, Briand G, Guillochon D: Isolation and characterization of four antibacterial peptides from bovine hemoglobin. Peptides 2006; 27: 2082-2089.
9. Fogaca AC, da Silva PI, Jr, Miranda MT, Bianchi AG, Miranda A, Ribolla PE, Daffre S: Antimicrobial activity of a bovine hemoglobin fragment in the tick Boophilus microplus. J Biol Chem 1999; 274: 25330-25334.
10. Nakajima Y, Ogihara K, Taylor D, Yamakawa M: Antibacterial hemoglobin fragments from the midgut of the soft tick, Ornithodoros moubata (Acari: Argasidae). J Med Entomol 2003; 40: 78-81.
11. Liepke C, Baxmann S, Heine C, Breithaupt N, Standker L, Forssmann WG: Human hemoglobin-derived peptides exhibit antimicrobial activity: A class of host defense peptides. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 791: 345-356.
12. Mak P, Wójcik K, Wicherek L, Suder P, Dubin A: Antibacterial hemoglobin peptides in human menstrual blood. Peptides 2004; 25: 1839-1847.
13. Mak P, Wicherek L, Suder P, Dubin A, Banas T, Kaim I, Klimek M: Analysis of free hemoglobin level and hemoglobin peptides from human puerperal uterine secretions. J Soc Gynecol Investig 2006; 13: 285-291.
14. Wicherek L, Mak P, Klimek M, Banas T: The length of menstrual bleeding and the risk of urogenital infections in the context of the activity of hemoglobin-derived microbicidal peptides. Eur J Obstet Gynecol Reprod Biol 2006; in press.
15. Karelin AA, Philippova MM, Ivanov VT: Proteolytic degradation of hemoglobin in erythrocytes leads to biologically active peptides. Peptides 1995; 16: 693-697.
16. Ivanov VT, Karelin AA, Yatskin ON: Generation of peptides by human erythrocytes: Facts and artifacts. Biopolymers 2005; 80: 332-346.
17. Beier HM, Beier-Hellwig K: Molecular and cellular aspects of endometrial receptivity. Hum Reprod Update 1998; 4: 448-458.
18. Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: Purification, characterization, and antimicrobial testing. Methods Enzymol 1994; 236: 160-172.
19. Fassman GD: Practical Handbook of Biochemistry and Molecular Biology. Cleveland, OH, CRC Press, 1989.
20. Colombie S, Gaunand A, Lindet B: Lysozyme inactivation under mechanical stirring: Effect of physical and molecular interfaces. Enzyme Microb Technol 2001; 28: 820-826.
21. Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci 2005; 40: 123-132.
22. Hancock RE, Diamond G: The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol 2000; 8: 402-410.
23. Papo N, Shai Y: Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes? Peptides 2003; 24: 1693-1703.
24. Sitaram N, Nagaraj R: Interaction of antimicrobial peptides with biological and model membranes: Structural and charge requirements for activity. Biochim Biophys Acta 1999; 1462: 29-54.
25. Owen DH, Katz DF: A vaginal fluid simulant. Contraception 1999; 59: 91-95.
26. Standley CA, Whitty JE, Mason BA, Cotton DB: Serum ionized magnesium levels in normal and preeclamptic gestation. Obstet Gynecol 1997; 89: 24-27.
27. Balu RB, Savitz DA, Ananth CV, Hartmann KE, Miller WC, Thorp JM, Heine RP: Bacterial vaginosis and vaginal fluid defensins during pregnancy. Am J Obstet Gynecol 2002; 187: 1267-1271.
28. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, Kagnoff MF: Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 2003; 125: 1613-1625.
29. Tjabringa GS, Vos JB, Olthuis D, Ninaber DK, Rabe KF, Schalkwijk J, Hiemstra PS, Zeeuwen PL: Host defense effector molecules in mucosal secretions. FEMS Immunol Med Microbiol 2005; 45: 151-158.
30. Niyonsaba F, Ogawa H: Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci 2005; 40: 157-168.
31. Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M: Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm Res 2000; 49: 73-79.
32. Diamond G,EBevins CL: Beta-defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunopathol 1998; 88: 221-225.
33. Selsted ME, Ouellette AJ: Defensins in granules of phagocytic and non-phagocytic cells. Trends Cell Biol 1995; 5: 114-119.
34. RamanathaM B, Davis EG, Ross CR, Blecha F: Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect 2002; 4: 361-372.
35. Schroder JM: Epithelial peptide antibiotics. Biochem Pharmacol 1999; 57: 121-134.
36. During K, Porsch P, Mahn A, Brinkmann O, Gieffers W: The non-enzymatic microbicidal activity of lysozymes. FEBS Lett 1999; 449: 93-100.
37. Ibrahim HR, Matsuzaki T, Aoki T: Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function. FEBS Lett 2001; 506: 27-32.
38. Ibrahim HR, Thomas U, Pellegrini A: A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action. J Biol Chem 2001; 276: 43767-43774.
39. Chun W, Hancock RE: Action of lysozyme and nisin mixtures against lactic acid bacteria. Int J Food Microbiol 2000; 60: 25-32.
40. Patrzykat A, Zhang L, Mendoza V, Iwama GK, Hancock RE: Synergy of histone-derived peptides of coho salmon with lysozyme and flounder pleurocidin. Antimicrob Agents Chemother 2001; 45: 1337-1342.