Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: Effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation

Journal of Virology

Volumn 80, Issue 24, 2006, Pages 12312-12323

  Jacobson, Jennie G ^a,c   Yang, Kui ^b   Baines, Joel D ^b   Homa, Fred L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GENE PRODUCT; PROTEIN UL15; PROTEIN UL28; PROTEIN UL33; VIRUS DNA; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA PACKAGING; DNA SEQUENCE; GENE IDENTIFICATION; GENE INSERTION; GENE ISOLATION; GENE MUTATION; GENETIC COMPLEMENTATION; HERPES SIMPLEX VIRUS 1; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVERTANT; UL15 GENE; UL28 GENE; UL33 GENE; VERO CELL; VIRUS GENE; VIRUS GENOME; VIRUS MUTANT; VIRUS PLAQUE;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, SOUTHERN; CERCOPITHECUS AETHIOPS; DNA PACKAGING; GENETIC COMPLEMENTATION TEST; HERPESVIRUS 1, HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; SEQUENCE ANALYSIS, DNA; VERO CELLS; VIRAL PROTEINS;

HUMAN HERPESVIRUS 1;

EID: 33845461933     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01766-06     Document Type: Article

References (40)

1. Abbotts, A. P., V. G. Preston, M. Hughes, A. H. Patel, and N. D. Stow. 2000. Interaction of the herpes simplex virus type 1 packaging protein UL15 with full-length and deleted forms of the UL28 protein. J. Gen. Virol. 81:2999-3009.
2. Addison, C., F. J. Rixon, and V. G. Preston. 1990. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids. J. Gen. Virol. 71:2377-2384.
3. Adelman, K., B. Salmon, and J. D. Baines. 2001. Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery. Proc. Natl. Acad. Sci. USA 98:3086-3091.
4. al-Kobaisi, M. F., F. J. Rixon, I. McDougall, and V. G. Preston. 1991. The herpes simplex virus UL33 gene product is required for the assembly of full capsids. Virology 180:380-388.
5. Beard, P. M., and J. D. Baines. 2004. The DNA cleavage and packaging protein encoded by the U(L)33 gene of herpes simplex virus 1 associates with capsids. Virology 324:475-482.
6. L33 of herpes simplex virus type 1 form a complex in infected cells. J. Virol. 76:4785-4791.
7. Black, L. 1988. DNA packaging in dsDNA bacteriophages, p. 321-373. In R. Calendar (ed.), The bacteriophages, vol. 2. Plenum Press, New York, N.Y.
8. Bogner, E., K. Radsak, and M. F. Stinski. 1998. The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity. J. Virol. 72:2259-2264.
9. Brown, J., M. A. McVoy, and F. L. Homa. 2002. Packaging DNA into herpesvirus capsids, p. 111-155. In A. H. E. Bogner (ed.), Structure-function relationships of human pathogenic viruses. Kluwer Academic/Plenum Publishers, New York, N.Y.
10. Cavalcoli, J. D., A. Baghian, F. L. Homa, and K. G. Kousoulas. 1993. Resolution of genotypic and phenotypic properties of herpes simplex virus type 1 temperature-sensitive mutant (KOS) tsZ47: evidence for allelic complementation in the UL28 gene. Virology 197:23-34.
11. Chang, Y. E., A. P. Poon, and B. Roizman. 1996. Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1. J. Virol. 70:3938-3946.
12. Davison, A. J. 1992. Channel catfish virus: a new type of herpesvirus. Virology 186:9-14.
13. Goldin, A. L., R. M. Sandri-Goldin, M. Levine, and J. C. Glorioso. 1981. Cloning of herpes simplex virus type 1 sequences representing the whole genome. J. Virol. 38:50-58.
14. Holland, L. E., R. M. Sandri-Goldin, A. L. Goldin, J. C. Glorioso, and M. Levine. 1984. Transcriptional and genetic analyses of the herpes simplex virus type 1 genome: coordinates 0.29 to 0.45. J. Virol. 49:947-959.
15. Homa, F. L., and J. C. Brown. 1997. Capsid assembly and DNA packaging in herpes simplex virus. Rev. Med. Virol. 7:107-122.
16. 2) gene lie within bases -34 to +124 relative to the 5′ terminus of the mRNA. Mol. Cell. Biol. 6:3652-3666.
17. Koslowski, K. M., P. R. Shaver, J. T. Casey II, T. Wilson, G. Yamanaka, A. K. Sheaffer, D. J. Tenney, and N. E. Pederson. 1999. Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins. J. Virol. 73:1704-1707.
18. Koslowski, K. M., P. R. Shaver, X. Y. Wang, D. J. Tenney, and N. E. Pederson. 1997. The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein. J. Virol. 71:9118-9123.
19. Krosky, P. M., M. R. Underwood, S. R. Turk, K. W. Feng, R. K. Jain, R. G. Ptak, A. C. Westerman, K. K. Biron, L. B. Townsend, and J. C. Drach. 1998. Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56. J. Virol. 72:4721-4728.
20. Lamberti, C., and S. K. Weller. 1998. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments. J. Virol. 72:2463-2473.
21. Lamberti, C., and S. K. Weller. 1996. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion. Virology 226:403-407.
22. McGeoch, D. J., M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1531-1574.
23. McNab, A. R., P. Desai, S. Person, L. L. Roof, D. R. Thomsen, W. W. Newcomb, J. C. Brown, and F. L. Homa. 1998. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA. J. Virol. 72:1060-1070.
24. Mettenleiter, T. C., A. Saalmuller, and F. Weiland. 1993. Pseudorabies virus protein homologous to herpes simplex virus type 1 ICP18.5 is necessary for capsid maturation. J. Virol. 67:1236-1245.
25. Newcomb, W. W., R. M. Juhas, D. R. Thomsen, F. L. Homa, A. D. Burch, S. K. Weller, and J. C. Brown. 2001. The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. J. Virol. 75:10923-10932.
26. Patel, A. H., and J. B. MacLean. 1995. The product of the UL6 gene of herpes simplex virus type 1 is associated with virus capsids. Virology 206:465-478.
27. Pederson, N. E., J. T. Casey II, K. M. Koslowski, and P. R. Shaver. 1998. The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses. Oncol. Rep. 5:115-119.
28. Prevelige, P. E., Jr., and J. King. 1993. Assembly of bacteriophage P22: a model for ds-DNA virus assembly. Prog. Med. Virol. 40:206-221.
29. Przech, A. J., D. Yu, and S. K. Weller. 2003. Point mutations in exon I of the herpes simplex virus putative terminase subunit, UL15, indicate that the most conserved residues are essential for cleavage and packaging. J. Virol. 77:9613-9621.
30. Reynolds, A. E., Y. Fan, and J. D. Baines. 2000. Characterization of the U(L)33 gene product of herpes simplex virus 1. Virology 266:310-318.
31. L28 genes. J. Virol. 72:3045-3050.
32. L17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA. J. Virol. 72:3779-3788.
33. Sheaffer, A. K., W. W. Newcomb, M. Gao, D. Yu, S. K. Weller, J. C. Brown, and D. J. Tenney. 2001. Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation. J. Virol. 75:687-698.
34. Stow, N. D. 2001. Packaging of genomic and amplicon DNA by the herpes simplex virus type 1 UL25-null mutant KUL25NS. J. Virol. 75:10755-10765.
35. Tengelsen, L. A., N. E. Pederson, P. R. Shaver, M. W. Wathen, and F. L. Homa. 1993. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: isolation and characterization of two UL28 deletion mutants. J. Virol. 67:3470-3480.
36. Thurlow, J. K., M. Murphy, N. D. Stow, and V. G. Preston. 2006. Herpes simplex virus type 1 DNA-packaging protein UL17 is required for efficient binding of UL25 to capsids. J. Virol. 80:2118-2126.
37. White, C. A., N. D. Stow, A. H. Patel, M. Hughes, and V. G. Preston. 2003. Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28. J. Virol. 77:6351-6358.
38. Yang, K., and J. D. Baines. 2006. The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33. J. Virol. 80:5733-5739.
39. Yu, D., and S. K. Weller. 1998. Genetic analysis of the UL15 gene locus for the putative terminase of herpes simplex virus type 1. Virology 243:32-44.
40. Yu, D., and S. K. Weller. 1998. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging. J. Virol. 72:7428-7439.