γδ T cells promote anterior chamber-associated immune deviation and immune privilege through their production of IL-10

Journal of Immunology

Volumn 177, Issue 12, 2006, Pages 8331-8337

  Ashour, Hossam M ^a   Niederkorn, Jerry Y ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; OVALBUMIN; RECOMBINANT INTERLEUKIN 10; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CHAMBER ASSOCIATED IMMUNE DEVIATION; ANTERIOR EYE CHAMBER; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; KNOCKOUT MOUSE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL COMMUNICATION; IMMUNOLOGY; MOUSE MUTANT; SECRETION;

ANIMALS; ANTERIOR CHAMBER; ANTIGEN-PRESENTING CELLS; CELL COMMUNICATION; IMMUNE TOLERANCE; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES, REGULATORY;

EID: 33845452304     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.12.8331     Document Type: Article

References (57)

1. Niederkorn, J. Y. 2002. Immune privilege in the anterior chamber of the eye. Oil. Rev. Immunol. 22: 13-46.
2. Streilein, J. W. 2003. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat. Rev. Immunol. 3: 879-889.
3. Niederkorn, J. Y. 2006. See no evil, hear no evil, do no evil: the lessons of immune privilege. Nat. Immunol. 1: 354-359.
4. Sonoda, K. H., and J. Stein-Streilein. 2002. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur. J. Immunol. 32: 848-857.
5. Lin, H. H., D. E. Faunce, M. Stacey, A. Terajewicz, T. Nakamura, J. Zhang-Hoover, M. Kerley, M. L. Mucenski, S. Gordon, and J. Stein-Streilein. 2005. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J. Exp. Med. 201: 1615-1625.
6. + T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110: 18-29.
7. Skelsey, M. E., E. Mayhew, and J. Y. Niederkorn. 2003. Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation. Invest. Ophthalmol. Vis. Sci. 44: 5242-5251.
8. Ashour, H. M., and J. Y. Niederkorn. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J. Immunol. 176: 5950-5957.
9. D'Orazio, T. J., E. Mayhew, and J. Y. Niederkorn. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1. J. Immunol. 166: 26-32.
10. Guidos, C. 2006. Thymus and T-lymphocyte development: what is new in the 21st century? Immunol. Rev. 209: 5-9.
11. Harrison, L. C., M. Dempsey-Collier, D. R. Kramer, and K. Takahashi. 1996. Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J. Exp. Med. 184: 2167-2174.
12. Lusso, P., A. Garzino-Demo, R. W. Crowley, and M. S. Malnati. 1995. Infection of γδ T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. J. Exp. Med. 181: 1303-1310.
13. + CTL responses. Invest. Ophthalmol. Vis. Sci. 43: 3473-3479.
14. Skelsey, M. E., J. Mellon, and J. Y. Niederkorn. 2001. γδ T cells are needed for ocular immune privilege and corneal graft survival. J. Immunol. 166: 4327-4333.
15. Xu, Y., and J. A. Kapp. 2001. γδ T cells are critical for the induction of anterior chamber-associated immune deviation. Immunology 104: 142-148.
16. + cells suppress experimental autoimmune uveitis. Eur. J. Immunol. 26: 2140-2148.
17. Mengel, J., F. Cardillo, L. S. Aroeira, O. Williams, M. Russo, and N. M. Vaz. 1995. Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice. Immunol. Lett. 48: 97-102.
18. Ke, Y., K. Pearce, J. P. Lake, H. K. Ziegler, and J. A. Kapp. 1997. γδ T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158: 3610-3618.
19. + suppressor T cells. J. Immunol. 156: 916-921.
20. Okunuki, H., R. Teshima, Y. Sato, R. Nakamura, H. Akiyama, T. Maitani, and J. Sawada. 2005. The hyperresponsiveness of W/Wv mice to oral sensitization is associated with a decrease in TCP γδ-T cells. Biol. Pharm. Bull. 28: 584-590.
21. Mukasa, A., K. Hiromatsu, G. Matsuzaki, R. O'Brien, W. Born, and K. Nomoto. 1995. Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of αβ and γδ T cells. J. Immunol. 155: 2047-2056.
22. Seo, N., and K. Egawa. 1995. Suppression of cytotoxic T lymphocyte activity by γδ T cells in tumor-bearing mice. Cancer Immunol. Immunother. 40: 358-366.
23. McMenamin, C., M. McKersey, P. Kuhnlein, T. Hunig, and P. G. Holt. 1995. γδ T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J. Immunol. 154: 4390-4394.
24. Seo, N., Y. Tokura, M. Takigawa, and K. Egawa. 1999. Depletion of IL-10- and TGF-β-producing regulatory γδ T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells. J. Immunol. 163: 242-249.
25. Seo, N., Y. Tokura, F. Furukawa, and M. Takigawa. 1998. Down-regulation of tumoricidal NK and NKT cell activities by MHC Kb molecules expressed on Th2-type γδ T and αβ T cells coinfiltrating in early B16 melanoma lesions. J. Immunol. 161: 4138-4145.
26. Heyborne, K. D., R. L. Cranfill, S. R. Carding, W. K. Born, and R. L. O'Brien. 1992. Characterization of γδ T lymphocytes at the maternal-fetal interface. J. Immunol. 149: 2872-2878.
27. Suzuki, T., K. Hiromatsu, Y. Ando, T. Okamoto, Y. Tomoda, and Y. Yoshikai. 1995. Regulatory role of γδ T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response. J. Immunol. 154: 4476-4484.
28. Mathis, D., and C. Benoist. 2004. Back to central tolerance. Immunity 20: 509-516.
29. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
30. Wenkel, H., J. W. Streilein, and M. J. Young. 2000. Systemic immune deviation in the brain that does not depend on the integrity of the blood-brain barrier. J. Immunol. 164: 5125-5131.
31. Sonoda, K. H., M. Exley, S. Snapper, S. P. Balk, and J. Stein-Streilein. 1999. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190: 1215-1226.
32. Sonoda, K. H., D. E. Faunce, M. Taniguchi, M. Exley, S. Balk, and J. Stein-Streilein. 2001. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J. Immunol. 166: 42-50.
33. Wang, Y., I. Goldschneider, J. O'Rourke, and R. E. Cone. 2001. Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation. J. Leukocyte Biol. 69: 741-746.
34. D'Orazio, T. J., and J. Y. Niederkorn. 1998. Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber-associated immune deviation (ACAID). Immunology 95: 47-55.
35. Niederkorn, J. Y. 2003. Mechanisms of immune privilege in the eye and hair follicle. J. Investig. Dermatol. Symp. Proc. 8: 168-172.
36. Wilbanks, G. A., and J. W. Streilein. 1990. Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen: evidence of two functionally and phenotypically distinct T-suppressor cell populations. Immunology 71: 383-389.
37. Brandes, M., K. Willimann, and B. Moser. 2005. Professional antigen-presentation function by human γδ T cells. Science 309: 264-268.
38. Moser, B., and M. Brandes. 2006. γδ T cells: an alternative type of professional APC. Trends Immunol. 27: 112-118.
39. Hara, Y., R. R. Caspi, B. Wiggert, M. Dorf, and J. W. Streilein. 1992. Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye. J. Immunol. 149: 1531-1538.
40. Wen, L., D. F. Barber, W. Pao, F. S. Wong, M. J. Owen, and A. Hayday. 1998. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160: 1965-1974.
41. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373: 255-257.
42. Seo, N., and Y. Tokura. 1999. Down-regulation of innate and acquired antitumor immunity by bystander γδ and αβ T lymphocytes with Th2 or Tr1 cytokine profiles. J. Interferon Cytokine Res. 19: 555-561.
43. Ebert, L. M., S. Meuter, and B. Moser. 2006. Homing and function of human skin γδ T cells, and NK cells: relevance for tumor surveillance. J. Immunol. 176: 4331-4336.
44. Wang, T., E. Scully, Z. Yin, J. H. Kim, S. Wang, J. Yan, M. Mamula, J. F. Anderson, J. Craft, and E. Fikrig. 2003. IFN-γ-producing γδ T cells help control murine West Nile virus infection. J. Immunol. 171: 2524-2531.
45. Kapp, J. A., L. M. Kapp, K. C. McKenna, and J. P. Lake. 2004. γδ T-cell clones from intestinal intraepithelial lymphocytes inhibit development of CTL responses ex vivo. Immunology 111: 155-164.
46. Wood, K. J., and B. Sawitzki. 2006. Interferon-γ: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol. 27: 183-187.
47. Niederkorn, J. Y., and J. Mellon. 1996. Anterior chamber-associated immune deviation promotes corneal allograft survival. Invest. Ophthalmol. Vis. Sci. 37: 2700-2707.
48. Sonoda, Y., and J. W. Streilein. 1993. Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts. J. Immunol. 150: 1727-1734.
49. Mizuno, K., A. F. Clark, and J. W. Streilein. 1989. Anterior chamber-associated - immune deviation induced by soluble antigens. Invest. Ophthalmol. Vis. Sci. 30: 1112-1119.
50. + T cells. J. Immunol. 169: 5630-5637.
51. Faunce, D. E., K. H. Sonoda, and J. Stein-Streilein. 2001. MIP-2 recruits NKT cells to the spleen during tolerance induction. J. Immunol. 166: 313-321.
52. Wilbanks, G. A., and J. W. Streilein. 1992. Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties. Reg. Immunol. 4: 130-137.
53. + T cells to the spleen during the generation of regulatory T cells in tolerance. J. Immunol. 169: 31-38.
54. D'Orazio, T. J., and J. Y. Niederkorn. 1998. A novel role for TGF-β and IL-10 in the induction of immune privilege. J. Immunol. 160: 2089-2098.
55. Holtmeier, W., and D. Kabelitz. 2005. γδ T cells link innate and adaptive immune responses. Chem. Immunol. Allergy 86: 151-183.
56. Ke, Y., L. M. Kapp, and J. A. Kapp. 2003. Inhibition of tumor rejection by γδ T cells and IL-10. Cell. Immunol. 221: 107-114.
57. Born, W. K., C. L. Reardon, and R. L. O'Brien. 2006. The function of γδ T cells in innate immunity. Curr. Opin. Immunol. 18: 31-38.