Sympathetic responses to exercise in myocardial infarction rats: A role of central command

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 6, 2006, Pages

  Koba, Satoshi ^a   Gao, Zhaohui ^a   Xing, Jihong ^a   Sinoway, Lawrence I ^a   Li, Jianhua ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Congestive heart failure; Lumbar sympathetic nerve activity; Mesencephalic locomotor region; Renal sympathetic nerve activity

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN REGION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROSTIMULATION; EVOKED RESPONSE; EXERCISE; HEART INFARCTION; KIDNEY NERVE; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE; VASOCONSTRICTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; ELECTRIC STIMULATION; HEART FAILURE, CONGESTIVE; HINDLIMB; KIDNEY; LOCOMOTION; MALE; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL INFARCTION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION;

EID: 33845417674     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00522.2006     Document Type: Article

References (54)

1. Argyle SA, Dargie H, and McGraph JC. Alteration in vascular reactivity in isolated vessels segments from dogs with naturally occurring heart failure. Res Vet Sci 67: 277-284, 1999.
2. Bagshaw EV and Evans MH. Measurement of current spread from microelectrodes when stimulating within the nervous system. Exp Brain Res 25: 391-400, 1976.
3. Barman SM and Gebber GL. Hypothalamic neurons with activity patterns related to sympathetic nerve discharge. Am J Physiol Regul Integr Comp Physiol 242: R34-R43, 1982.
4. Bayev KV, Beresovskii VK, Kebkalo TG, and Savoskina LA. Afferent and efferent connections of brainstem locomotor regions: study by means of horseradish peroxidase transport technique. Neuroscience 26: 871-891, 1988.
5. Bedford TG, Loi PK, and Crandall CC. A model of dynamic exercise: the decerebrate rat locomotor preparation. J Appl Physiol 72: 121-127, 1992.
6. Dargie H. Sympathetic activation and regional blood flow in heart failure. Eur Heart J 11: 39-43, 1990.
7. Degtyarenko AM and Kaufman MP. Spinoreticular neurons that receive group III input are inhibited by MLR stimulation. J Appl Physiol 93: 92-98, 2002.
8. DiBona GF and Sawin LL. Frequency response of the renal vasculature in congestive heart failure. Circulation 107: 2159-2164, 2003.
9. Eldridge FL, Milhorn DE, Kiley JP, and Waldrop TG. Stimulation by central command of locomotion, respiration, and circulation during exercise. Respir Physiol 59: 313-337, 1985.
10. Felder RB, Francis J, Zhang ZH, Wei SG, Weiss RM, and Johnson AK. Heart failure and the brain: new perspectives. Am J Physiol Regul Integr Comp Physiol 284: R259-R276, 2003.
11. Garcia-Rill E, Skinner RD, Conrad C, Mosley D, and Campbell C. Projection of the mesencephalic locomotor region in the rat. Brain Res Bull 17: 33-40, 1986.
12. Gschwend S, Henning RH, Pinto YM, de Zeeuw D, van Gilst WH, and Buikema H. Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade. Br J Pharmacol 139: 1317-1325, 2003.
13. Hammond RL, Augustyniak RA, Rossi NF, Lapanowski K, Dunbar JC, and O'Leary DS. Alteration of humoral and peripheral vascular responses during graded exercise in heart failure. J Appl Physiol 90: 55-61, 2001.
14. Hayes SG and Kaufman MP. MLR stimulation and exercise pressor reflex activate different renal sympathetic fibers in decerebrate cats. J Appl Physiol 92: 1628-1634, 2002.
15. Ikenaga H, Ishii N, Didion SP, Zhang K, Cornish KG, Patel KP, Mayhan WG, and Carmines PK. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic heart failure. Am J Physiol Renal Physiol 276: F79-F87, 1999.
16. Iwamoto GA, Wappel SM, Fox GM, Buetow KA, and Waldrop TG. Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res 726: 109-122, 1996.
17. Jordan LM. Initiation of locomotion in mammals. Ann NY Acad Sci 860: 83-93, 1998.
18. Kaufman MP and Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 10, p. 381-447.
19. Kerman IA, Akil H, and Watson SJ. Rostral elements of sympathomotor circuitry: a virully mediated transsynaptic tracing study. J Neurosci 26: 3423-3433, 2006.
20. Kerman IA, Enquist LW, Watson SJ, and Yates BJ. Brainstem substrates of sympatho-motor circuitry identified using trans-synaptic tracing with pseudorabies virus recombinants. J Neurosci 23: 4657-4666, 2003.
21. Koba S, Yoshida T, and Hayashi N. Differential sympathetic outflow and vasoconstriction responses at kidney and skeletal muscles during fictive locomotion. Am J Physiol Heart Circ Physiol 290: H861-H868, 2006.
22. Krout KE, Mettenleiter TC, and Loewy AD. Single CNS neurons link both motor and cardiosympathetic systems: a double-virus tracing study. Neuroscience 118: 853-866, 2003.
23. Laughlin MH. Cardiovascular responses to exercise. Am J Physiol Advan Physiol Educ 277: S244-S259, 1999.
24. Leimbach WN Jr, Wallin BG, Victor RG, Aylward PE, Sundlof G, and Mark AL. Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation 73: 913-919, 1986.
25. LeJemtel TH, Maskin CS, Lucido D, and Chadwick BJ. Failure to augment maximal limb blood flow in response to one-leg vs. two-leg exercise in patients with severe heart failure. Circulation 74: 245-251, 1986.
26. Li J, Sinoway AN, Gao Z, Maile MD, Pu M, and Sinoway LI. Muscle mechano and mataboreflex responses after myocardial infarctions in rats. Circulation 110: 3049-3054, 2004.
27. McClain J, Hardy C, Enders B, Smith M, and Sinoway L. Limb congestion and sympathoexcitation during exercise: implications for congestive heart failure. J Clin Invest 92: 2353-2359, 1993.
28. McIlveen SA, Hayes SG, and Kaufman MP. Both central command and exercise pressor reflex reset carotid sinus baroreflex. Am J Physiol Heart Circ Physiol 280: H1454-H1463, 2001.
29. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, and Patel J. Muscle mechanoreceptor sensitivity in heart failure. Am J Physiol Heart Circ Physiol 287: H1937-H1943, 2004.
30. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, and Moriguchi JD. Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure. J Appl Physiol 90: 1714-1719, 2001.
31. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, and Moriguchi JD. Exaggerated renal vasoconstriction during exercise in heart failure patients. Circulation 101: 784-789, 2000.
32. Miki K, Kosho A, and Hayashida Y. Method for continuous measurements of renal sympathetic nerve activity and cardiovascular function during exercise in rats. Exp Physiol 87: 33-39, 2002.
33. Miki K, Oda M, Kamijo N, Kawahara K, and Yoshimoto M. Lumbar sympathetic nerve activity and hindquarter blood flow during REM sleep in rats. J Physiol 557: 261-271, 2004.
34. Momen A, Bower D, Boehmer J, Kunselman AR, Leuenberger UA, and Sinoway LI. Renal blood flow in heart failure patients during exercise. Am J Physiol Heart Circ Physiol 287: H2834-H2839, 2004.
35. Musch TI and Terrell JA. Skeletal muscle blood flow abnormalities in rats with a chronic myocardial infarction: rest and exercise. Am J Physiol Heart Circ Physiol 262: H411-H419, 1992.
36. Negrao CE, Brandao Rondon MUP, Tinucci T, Alves MJN, Roveda F, Braga AMW, Reis SF, Nastari L, Barretto ACP, Krieger EM, and Middlekauff HR. Abnormal neurovascular control during exercise is linked to heart failure severity. Am J Physiol Heart Circ Physiol 280: H1286-H1292, 2001.
37. Patel KP, Zhang K, Kenney MJ, Weiss M, and Mayhan WG. Neuronal expression of Fos protein in the hypothalamus of rats with heart failure. Brain Res 865: 27-34, 2000.
38. Patel KP, Zhang K, Zucker IH, and Krukoff TL. Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brain-stem of rats in heart failure. Brain Res 734: 109-115, 1996.
39. Plowey ED, Kramer JM, Beatty JA, and Waldrop TG. In vivo electrophysiological responses of pedunculopontine neurons to static muscle contraction. Am J Physiol Regul Integr Comp Physiol 283: R1008-R1019, 2002.
40. Sakai K, Hirooka Y, Shigematsu H, Kishi T, Ito K, Shimokawa H, Takeshita A, and Sunagawa K. Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction. Am J Physiol Heart Circ Physiol 289: H2159-H2166, 2005.
41. Shoemaker JK, Nayolor HL, Hogeman CS, and Sinoway LI. Blood flow dynamics in heart failure. Circulation 99: 3002-3008, 1999.
42. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, and Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol 84: 1551-1559, 1998.
43. Skinner RD and Garcia-Rill E. The mesencephalic locomotor region (MLR) in the rat. Brain Res 323: 385-389, 1984.
44. Smith SA, Mitchell JH, Naseem H, and Garry MG. Mechanoreflex mediates the exaggerated exercise pressor reflex in heart failure. Circulation 112: 2293-2300, 2005.
45. Smith SA, Mammen PPA, Mitchell JH, and Garry MG. Role of the exercise pressor reflex in rats with dilated cardiomyopathy. Circulation 108: 1126-1132, 2003.
46. Smith SA, Williams MA, Mitchell JH, Mammen PPA, and Garry MG. The capsaicin-sensitive afferent neuron in skeletal muscle is abnormal in heart failure. Circulation 111: 2056-2065, 2005.
47. Sterns DA, Ettinger SM, Gray KS, Whisler SK, Mosher TJ, Smith MB, and Sinoway LI. Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure. Circulation 84: 2034-2039, 1991.
48. Thomas GD, Zhang W, and Victor RG. Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardiac infarction. Circ Res 88: 816-823, 2001.
49. Vahid-Ansari F and Leenen FHH. Pattern of neuronal activation in rats with CHF after myocardial infarction. Am J Physiol Heart Circ Physiol 275: H2140-H2146, 1998.
50. Waldrop TG, Eldridge FL, Iwamoto GA, and Mitchell JH. Central neural control of respiration and circulation during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 9, p. 333-380.
51. Wilson JR and Mancini DM. Factors contributing to the exercise limitation of heart failure. J Am Coll Cardiol 22: 93A-98A, 1993.
52. Wilson JR, Matthai W, Lanoce V, Frey M, and Ferraro N. Effect of experimental heart failure on peripheral sympathetic vasoconstriction. Am J Physiol Heart Circ Physiol 254: H727-H733, 1988.
53. Zhang K, Li YF, and Patel KP. Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. Am J Physiol Heart Circ Physiol 281: H995-H1004, 2001.
54. Zheng H, Li YF, Cornish KG, Zucker IH, and Patel KP. Exercise training improves endogeneous nitric oxide mechanism within the paraventricular nucleus in rats with heart failure. Am J Physiol Heart Circ Physiol 288: H2332-H2341, 2005.