In vivo electrophysiological responses of pedunculopontine neurons to static muscle contraction

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 283, Issue 5 52-5, 2002, Pages

  Plowey, Edward D ^a   Kramer, Jeffery M ^a   Beatty, Joseph A ^a   Waldrop, Tony G ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Pedunculopontine nucleus; Respiration

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXERCISE; HYPOTENSION; HYPOTHALAMUS; HYPOXIA; MALE; MUSCLE CONTRACTION; MUSCLE REFLEX; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NONHUMAN; PONS ANGLE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RESPIRATORY DRIVE;

EID: 0036839459     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00075.2002     Document Type: Article

References (46)

1. Bauer RM, Iwamoto GA, and Waldrop TG. Ventrolateral medullary pressor neurons modulate pressor reflex to muscular contraction. Am J Physiol Regul Integr Comp Physiol 257: R1154-R1161, 1989.
2. Bauer RM, Iwamoto GA, and Waldrop TG. Discharge patterns of ventrolateral medullary neurons during muscular contraction. Am J Physiol Regul Integr Comp Physiol 259: R606-R611, 1990.
3. Bayev KV, Beresovskii VK, Kebkalo TG, and Savoskina LA. Afferent and efferent connections of brainstem locomotor regions: Study by means of horseradish peroxidase transport technique. Neuroscience 26: 871-891, 1988.
4. Bedford TG, Loi PK, and Crandall CC. A model of dynamic exercise: The decerebrate rat locomotor preparation. J Appl Physiol 72: 121-127, 1992.
5. Bellingham MC and Funk GD. Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination. Clin Exp Pharmacol Physiol 27: 132-137, 2000.
6. 1: Insights into attention and arousal. Pediatr Neurosurg 20: 57-62, 1994.
7. Chen Z, Eldridge FL, and Wagner PG. Respiratory-associated rhythmic firing of midbrain neurones in cats: Relation to level of respiratory drive. J Physiol 437: 305-325, 1991.
8. Chong RK and Bedford TG. Heart rate, blood pressure, and running speed responses to mesencephalic locomotor region stimulation in anesthetized rats. Pflügers Arch 434: 280-284, 1997.
9. Degtyarenko AM and Kaufman MP. Stimulation of the MLR inhibits the discharge of dorsal horn neurons responsive to muscular contraction. Brain Res 880: 178-182, 2000.
10. Eldridge FL and Chen Z. Respiratory-associated rhythmic firing of midbrain neurons is modulated by vagal input. Respir Physiol 90: 31-46, 1992.
11. Eldridge FL, Millhorn DE, Kiley JP, and Waldrop TG. Stimulation by central command of locomotion, respiration and circulation during exercise. Respir Physiol 59: 313-337, 1985.
12. Eldridge FL, Millhorn DE, and Waldrop TG. Exercise hyperpnea and locomotion: Parallel activation from the hypothalamus. Science 211: 844-846, 1981.
13. Fisher ML and Nutter DO. Cardiovascular reflex adjustments to static muscular contractions in the canine hindlimb. Am J Physiol 226: 648-655, 1974.
14. Friedman DB, Peel C, and Mitchell JH. Cardiovascular responses to voluntary and nonvoluntary static exercise in humans. J Appl Physiol 73: 1982-1985, 1992.
15. Garcia-Rill E. The pedunculopontine nucleus. Prog Neurobiol 36: 363-389, 1991.
16. Garcia-Rill E. The basal ganglia and the locomotor regions. Brain Res 396: 47-63, 1986.
17. Garcia-Rill E, Houser CR, Skinner RD, Smith W, and Woodward DJ. Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus. Brain Res Bull 18: 731-738, 1987.
18. Garcia-Rill E, Kinjo N, Atsuta Y, Ishikawa Y, Webber M, and Skinner RD. Posterior midbrain-induced locomotion. Brain Res Bull 24: 499-508, 1990.
19. Garcia-Rill E, Skinner RD, and Fitzgerald JA. Activity in the mesencephalic locomotor region during locomotion. Exp Neurol 82: 609-622, 1983.
20. Hayashi N, Hayes SG, and Kaufman MP. Comparison of the exercise pressor reflex between forelimb and hindlimb muscles in cats. Am J Physiol Regul Integr Comp Physiol 281: R1127-R1133, 2001.
21. Hilton SM. The defence-arousal system and its relevance for circulatory and respiratory control. J Exp Biol 100: 159-174, 1982.
22. Hilton SM and Redfern WS. A search for brain stem cell groups integrating the defence reaction in the rat. J Physiol 378: 213-228, 1986.
23. Horn EM and Waldrop TG. Modulation of the respiratory responses to hypoxia and hypercapnia by synaptic input onto caudal hypothalamic neurons. Brain Res 664: 25-33, 1994.
24. Hugelin A and Cohen MI. The reticular activating system and respiratory regulation in the cat. Ann NY Acad Sci 109: 586-603, 1963.
25. Iwamoto GA, Wappel SM, Fox GM, Buetow KA, and Waldrop TG. Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res 726: 109-122, 1996.
26. Kaufman MP and Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 10, p. 381-447.
27. Kramer JM, Aragones A, and Waldrop TG. Reflex cardiovascular responses originating in exercising muscles of mice. J Appl Physiol 90: 579-55, 2001.
28. Kramer JM and Waldrop TG. Spontaneously hypertensive rats exhibit altered cardiovascular and neuronal responses to muscle contraction. Exp Physiol 86: 717-724, 2001.
29. Lydic R and Baghdoyan HA. Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation. Am J Physiol Regul Integr Comp Physiol 264: R544-R554, 1993.
30. McCloskey DI and Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
31. Menetrey D, Chaouch A, and Besson JM. Location and properties of dorsal horn neurons at origin of spinoreticular tract in lumbar enlargement of the rat. J Neurophysiol 44: 862-877, 1980.
32. Mitchell JH. Cardiovascular control during exercise: Central and reflex neural mechanisms. Am J Cardiol 55: 34D-41D, 1985.
33. Nolan PC and Waldrop TG. Integrative role of medullary neurons of the cat during exercise. Exp Physiol 82: 547-558, 1997.
34. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic, 1997.
35. Rybicki KJ, Stremel RW, Iwamoto GA, Mitchell JH, and Kaufman MP. Occlusion of pressor responses to posterior diencephalic stimulation and muscular contraction. Brain Res Bull 22: 305-312, 1989.
36. Smith SA, Mitchell JH, and Garry MG. Electrically induced static exercise elicits a pressor response in the decerebrate rat. J Physiol 537: 961-970, 2001.
37. Solomon IC and Adamson TP. Static muscular contraction elicits a pressor reflex in the chicken. Am J Physiol Regul Integr Comp Physiol 272: R759-R765, 1997.
38. Toney GM and Mifflin SW. Mediators of contraction-evoked skeletal muscle depressor response in anesthetized rats. J Appl Physiol 81: 578-585, 1996.
39. Vincent SR, Satoh K, Armstrong DM, and Fibiger HC. NADPH-diaphorase: A selective histochemical marker for the cholinergic neurons of the pontine reticular formation. Neurosci Lett 43: 31-36, 1983.
40. Vissing J, Wilson LB, Mitchell JH, and Victor RG. Static muscle contraction reflexly increases adrenal sympathetic nerve activity in rats. Am J Physiol Regul Integr Comp Physiol 261: R1307-R1312, 1991.
41. Waldrop TG. Respiratory responses and adaptations to exercise. In: Scientific Foundations of Sports Medicine, edited by Teitz CC. Toronto, Canada: Dekker, 1989, p. 59-76.
42. Waldrop TG, Bauer RM, and Iwamoto GA. Microinjection of GABA antagonists into the posterior hypothalamus elicits locomotor activity and a cardiorespiratory activation. Brain Res 444: 84-94, 1988.
43. Waldrop TG, Eldridge FL, Iwamoto GA, and Mitchell JH. Central neural control of respiration and circulation during exercise. In: Handbook of Physiology. Exercise. Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc, 1996, sect. 12, chapt. 9, p. 333-380.
44. Waldrop TG, Mullins DC, and Millhorn DE. Control of respiration by the hypothalamus and by feedback from contracting muscles in cats. Respir Physiol 64: 317-328, 1986.
45. Waldrop TG and Stremel RW. Muscular contraction stimulates posterior hypothalamic neurons. Am J Physiol Regul Integr Comp Physiol 256: R348-R356, 1989.
46. Wilson LB, Andrew D, and Craig AD. Activation of spinobulbar lamina I neurons by static muscle contraction. J Neurophysiol 87: 1641-1645, 2002.