Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes

Molecular and Biochemical Parasitology

Volumn 151, Issue 1, 2007, Pages 59-69

  Pachebat, Justin A ^a   Kadekoppala, Madhusudan ^a   Grainger, Munira ^a   Dluzewski, Anton R ^b   Gunaratne, Ruwani S ^a   Scott Finnigan, Terence J ^a   Ogun, Solabomi A ^a   Ling, Irene T ^a   Bannister, Lawrence H ^b   Taylor, Helen M ^a   Mitchell, Graham H ^b   Holder, Anthony A ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

Malaria; Merozoite; Plasmodium; Protein processing

Indexed keywords

BREFELDIN A; CALCIUM CHELATING AGENT; MEROZOITE SURFACE PROTEIN 7; PARASITE ANTIGEN; SERINE PROTEINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ERYTHROCYTE; MEROZOITE; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ANIMALS; BREFELDIN A; ERYTHROCYTES; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; PEPTIDE HYDROLASES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; SCHIZONTS; SPECTROMETRY, FLUORESCENCE;

PLASMODIUM FALCIPARUM;

EID: 33845416940     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2006.10.006     Document Type: Article

References (40)

1. Marshall V.M., Silva A., Foley M., et al. A second merozoite surface protein (MSP-4) of Plasmodium falciparum that contains an epidermal growth factor-like domain. Infect Immun 65 (1997) 4460-4467
2. Trucco C., Fernandez-Reyes D., Howell S., et al. The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol 112 (2001) 91-101
3. Pachebat J.A., Ling I.T., Grainger M., et al. The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7. Mol Biochem Parasitol 117 (2001) 83-89
4. Stafford W.H., Gunder B., Harris A., Heidrich H.G., Holder A.A., and Blackman M.J. A 22 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol 80 (1996) 159-169
5. Peterson J., Marshall V.M., Smythe J.A., Crewther P.E., Lew A., and Silva A. Integral membrane protein located in the apical complex of Plasmodium falciparum. Mol Cell Biol 9 (1989) 3151-3154
6. Narum D.L., and Thomas A.W. Differential localization of full-length and processed forms of PF83/AMA-1, an apical membrane antigen of Plasmodium falciparum merozoites. Mol Biochem Parasitol 67 (1994) 59-68
7. Blackman M.J., Heidrich H.G., Donachie S., McBride J.S., and Holder A.A. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med 172 (1990) 379-382
8. Blackman M.J., Scott-Finnigan T.J., Shai S., and Holder A.A. Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein. J Exp Med 180 (1994) 389-393
9. r 185,000 glycoprotein from the surface of isolated Plasmodium falciparum merozoites form an antigenic complex. Mol Biochem Parasitol 23 (1987) 71-84
10. Holder A.A., Blackman M.J., Burghaus P.A., et al. A malaria merozoite surface protein (MSP1)-structure, processing and function. Mem Instit Oswaldo Cruz 87 Suppl 3 (1992) 37-42
11. Blackman M.J. Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1. Meth Cell Biol 45 (1994) 213-220
12. Fleck S.L., Birdsall B., Babon J., et al. Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. J Biol Chem 278 (2003) 47670-47677
13. 33 as a noncovalently associated complex with other fragments of the MSP1. Mol Biochem Parasitol 50 (1992) 307-315
14. Dutta S., Haynes J.D., Moch J.K., Barbosa A., and Lanar D.E. Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites. Proc Natl Acad Sci USA 100 (2003) 12295-12300
15. Goel V.K., Li X., Chen H., Liu S.C., Chishti A.H., and Oh S.S. Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes. Proc Natl Acad Sci USA 100 (2003) 5164-5169
16. Blackman M.J., Whittle H., and Holder A.A. Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kDa secondary processing product which is shed prior to erythrocyte invasion. Mol Biochem Parasitol 49 (1991) 35-44
17. Guevara Patino J.A., Holder A.A., McBride J.S., and Blackman M.J. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J Exp Med 186 (1997) 1689-1699
18. Holder A.A., and Freeman R.R. Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J Exp Med 156 (1982) 1528-1538
19. Pasvol G., Wilson R.J., Smalley M.E., and Brown J. Separation of viable schizont-infected red cells of Plasmodium falciparum from human blood. Ann Trop Med Parasitol 72 (1978) 87-88
20. Ling I.T., Florens L., Dluzewski A.R., et al. The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion. Mol Microbiol 52 (2004) 107-118
21. Pearce J.A., Triglia T., Hodder A.N., Jackson D.C., Cowman A.F., and Anders R.F. Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen. Infect Immun 72 (2004) 2321-2328
22. Stafford W.H., Blackman M.J., Harris A., Shai S., Grainger M., and Holder A.A. N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides. Mol Biochem Parasitol 66 (1994) 157-160
23. Blackman M.J., Fujioka H., Stafford W.H., et al. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites. J Biol Chem 273 (1998) 23398-23409
24. Blanco A.R., Paez A., Gerold P., et al. The biosynthesis and post-translational modification of Pbs21 an ookinete-surface protein of Plasmodium berghei. Mol Biochem Parasitol 98 (1999) 163-173
25. Das A., Elmendorf H.G., Li W.I., and Haldar K. Biosynthesis, export and processing of a 45 kDa protein detected in membrane clefts of erythrocytes infected with Plasmodium falciparum. Biochem J 302 Pt 2 (1994) 487-496
26. Hayashi M., Taniguchi S., Ishizuka Y., et al. A homologue of N-ethylmaleimide-sensitive factor in the malaria parasite Plasmodium falciparum is exported and localized in vesicular structures in the cytoplasm of infected erythrocytes in the brefeldin A-sensitive pathway. J Biol Chem 276 (2001) 15249-15255
27. Noe A.R., Fishkind D.J., and Adams J.H. Spatial and temporal dynamics of the secretory pathway during differentiation of the Plasmodium yoelii schizont. Mol Biochem Parasitol 108 (2000) 169-185
28. Ogun S.A., and Holder A.A. Plasmodium yoelii: brefeldin A-sensitive processing of proteins targeted to the rhoptries. Exp Parasitol 79 (1994) 270-278
29. Wiser M.F., Lanners H.N., Bafford R.A., and Favaloro J.M. A novel alternate secretory pathway for the export of Plasmodium proteins into the host erythrocyte. Proc Natl Acad Sci USA 94 (1997) 9108-9113
30. Myler P.J. Transcriptional analysis of the major merozoite surface protein (GP195) gene of Plasmodium falciparum. In: Agabian N., and Cerami A. (Eds). Parasites molecular biology, drug and vaccine design (1990), Wiley-Liss Inc., New York 123-137
31. Holder A.A. The precursor to major merozoite surface antigens: structure and role in immunity. Prog Allergy 41 (1988) 72-97
32. Holder A.A., Lockyer M.J., Odink K.G., et al. Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites. Nature 317 (1985) 270-273
33. Mello K., Daly T.M., Morrisey J., Vaidya A.B., Long C.A., and Bergman L.W. A multigene family that interacts with the amino terminus of Plasmodium MSP-1 identified using the yeast two-hybrid system. Eukaryot Cell 1 (2002) 915-925
34. Kauth C.W., Woehlbier U., Kern M., et al. Interactions between merozoite surface proteins 1, 6 and 7 of the malaria parasite Plasmodium falciparum. J Biol Chem 281 (2006) 31517-31527
35. Blackman M.J. Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets. Curr Drug Targets 1 (2000) 59-83
36. O'Donnell R.A., and Blackman M.J. The role of malaria merozoite proteases in red blood cell invasion. Curr Opin Microbiol 8 (2005) 422-427
37. Tewari R., Ogun S.A., Gunaratne R.S., Crisanti A., and Holder A.A. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo. Blood 105 (2005) 394-396
38. Florens L., Washburn M.P., Raine J.D., et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 419 (2002) 520-526
39. Le Roch K.G., Zhou Y., Blair P.L., et al. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301 (2003) 1503-1508
40. Mello K., Daly T.M., Long C.A., Burns J.M., and Bergman L.W. Members of the merozoite surface protein 7 family with similar expression patterns differ in ability to protect against Plasmodium yoelii malaria. Infect Immun 72 (2004) 1010-1018