pH dependency of ligand binding to cellobiohydrolase 1 (Cel7A). Affinity, selectivity and inhibition for designed propranolol analogues

Journal of Chromatography A

Volumn 1138, Issue 1-2, 2007, Pages 276-283

  Fagerström, Alexandra ^a   Nilsson, Mikael ^b   Berg, Ulf ^a   Isaksson, Roland ^b  

^a LUND UNIVERSITY   (Sweden)

^b LINNAEUS UNIVERSITY   (Sweden)

Author keywords

Affinity; Capillary electrophoresis; CE; Cel7A; Chiral; Dissociation constant; Enantiomer; Inhibition; Partial filling; pKa determination; Propranolol; Selectivity

Indexed keywords

AFFINITY CHROMATOGRAPHY; COMPUTATIONAL METHODS; DERIVATIVES; ELECTROPHORESIS; ELECTROSTATICS; PH EFFECTS; PROTEINS;

CAPILLARY ELECTROPHORESIS; CEL7A; CHIRALS; DISSOCIATION CONSTANTS; ENANTIOMERS; PARTIAL FILLING; PKA DETERMINATION; PROPRANOLOL; SELECTIVITY;

ENZYME INHIBITION;

1 (ANTHRACEN 9 YLOXY) 3 ISOPROPYLAMINOPROPAN 2 OL; 1 ISOPROPYLAMINO 3 (5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY)PROPAN 2 OL; 1 ISOPROPYLAMINO 3 (NAPHTHALEN 2 YLOXY)PROPAN 2 OL; 1 ISOPROPYLAMINO 3 (PHENANTHREN 9 YLOXY)PROPAN 2 OL; 2 [2 HYDROXY 3 (5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY)PROPYLAMINO]PROPANE 1,3 DIOL; 2 [2 HYDROXY 3 (NAPHTHALEN 1 YLOXY)PROPYLAMINO]PROPANE 1,3 DIOL; 2 [2 HYDROXY 3 (NAPHTHALEN 2 YLOXY)PROPAMINO]PROPANE 1,3 DIOL; 2 [2 HYDROXY 3 (PHENANTHREN 9 YLOXY)PROPYLAMINO]PROPANE 1,3 DIOL; 4 NITROPHENYL LACTOSIDE; AMINOALCOHOL; CEL 7 A; CELLULOSE 1,4 BETA CELLOBIOSIDASE; HYDROXYL GROUP; PROPRANOLOL DERIVATIVE;

AFFINITY CHROMATOGRAPHY; ALKALINITY; ARTICLE; BINDING AFFINITY; CAPILLARY ELECTROPHORESIS; DIHYDROXYLATION; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; ELECTRICITY; ENANTIOSELECTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; EVALUATION; LIGAND BINDING; MATHEMATICAL MODEL; PH; PH MEASUREMENT; PKA; PRIORITY JOURNAL; PROTEIN INTERACTION;

BINDING SITES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELLULOSE 1,4-BETA-CELLOBIOSIDASE; ELECTROSTATICS; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROPRANOLOL; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33845412465     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.10.098     Document Type: Article

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