Expression Changes in Tolerant Murine Cardiac Allografts After Gene Therapy With a Lentiviral Vector Expressing α1,3 Galactosyltransferase

Transplantation Proceedings

Volumn 38, Issue 10, 2006, Pages 3172-3180

  Evans, J M ^a   Doki, T ^a   Fischer Lougheed, J ^a   Davicioni, E ^a   Kearns Jonker, M ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; BIOTIN; CD209 ANTIGEN; CD56 ANTIGEN; COMPLEMENTARY RNA; DIPEPTIDYL PEPTIDASE IV; LENTIVIRUS VECTOR; PHOSPHODIESTERASE; PROTEIN KINASE B;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA HYBRIDIZATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; HEART; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOREGULATION; ISOGRAFT; KNOCKOUT MOUSE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS; VIRAL GENE THERAPY; WILD TYPE;

ANIMALS; BONE MARROW TRANSPLANTATION; GALACTOSYLTRANSFERASES; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENETIC VECTORS; HEART TRANSPLANTATION; IMMUNE TOLERANCE; LENTIVIRUS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SWINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 33845410583     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.10.176     Document Type: Article

References (50)

1. Matsui Y., Saiura A., Sugawara Y., et al. Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade. Physiol Genomics 15 (2003) 199
2. Spriewald B.M., Billing J.S., Ensminger S.M., et al. Linked unresponsiveness: early cytokine gene expression profiles in cardiac allografts following pretreatment of recipients with bone marrow cells expressing donor MHC alloantigen. Cytokine 19 (2002) 6
3. Mitsuhashi N., Fischer-Lougheed J., Shulkin I., et al. Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen. Blood 107 (2006) 2286
4. Kearns-Jonker M., Fischer-Lougheed J., Shulkin I., et al. Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts. Transplantation 77 (2004) 1748
5. Zhang Q., Chen Y., Fairchild R.L., et al. Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival. J Immunol 176 (2006) 770
6. Liu D., Shen X.D., Fang Z., et al. Identification of early tolerance regulator genes induced by allochimeric therapy using microarray-based genomewide scan. Transplant Proc 37 (2005) 1942
7. Napoli C., Lerman L.O., Sica V., et al. Microarray analysis: a novel research tool for cardiovascular scientists and physicians. Heart 89 (2003) 597
8. Mansfield E.S., and Sarwal M.M. Arraying the orchestration of allograft pathology. Am J Transplant 4 (2004) 853
9. Saiura A., Kohro T., Yamamoto T., et al. Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray. Transplantation 73 (2002) 1480
10. Christopher K., Mueller T.F., Liang Y., et al. Modulation of gene expression by alloimmune networks following murine heart transplantation. Mol Genet Genomics 271 (2004) 687
11. Erickson L.M., Pan F., Ebbs A., et al. Microarray-based gene expression profiles of allograft rejection and immunosuppression in the rat heart transplantation model. Transplantation 76 (2003) 582
12. Christopher K., Mueller T.F., DeFina R., et al. The graft response to transplantation: a gene expression profile analysis. Physiol Genomics 15 (2003) 52
13. Luckow B., Joergensen J., Chilla S., et al. Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol 34 (2004) 2568
14. Roussoulieres A.L., Raisky O., Chalabreysse L., et al. Identification and characterization of two genes (MIP-1beta, VE-CADHERIN) implicated in acute rejection in human heart transplantation: use of murine models in tandem with cDNA arrays. Circulation 111 (2005) 2636
15. Stegall M.D., Park W.D., Kim D.Y., et al. Changes in intragraft gene expression secondary to ischemia reperfusion after cardiac transplantation. Transplantation 74 (2002) 924
16. Amberger A., Schneeberger S., Hernegger G., et al. Gene expression profiling of prolonged cold ischemia and reperfusion in murine heart transplants. Transplantation 74 (2002) 1441
17. Saiura A., Sugawara Y., Harihara Y., et al. Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray. Transpl Int 15 (2002) 535
18. Souza A.I., Felkin L.E., McCormack A.M., et al. Sequential expression of three known protective genes in cardiac biopsies after transplantation. Transplantation 79 (2005) 584
19. Xu B., Sakkas L.I., Slachta C.A., et al. Apoptosis in chronic rejection of human cardiac allografts. Transplantation 71 (2001) 1137
20. Kuwaki K., Tseng Y.L., Dor F.J., et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 11 (2005) 29
21. Tseng Y.L., Kuwaki K., Dor F.J., et al. alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation 80 (2005) 1493
22. Milland J., Christiansen D., Lazarus B.D., et al. The molecular basis for ga-alpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene. J Immunol 176 (2006) 2448
23. Tearle R.G., Tange M.J., Zannettino Z.L., et al. The alpha-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation. Transplantation 61 (1996) 13
24. Saiura A., Mataki C., Murakami T., et al. A comparison of gene expression in murine cardiac allografts and isografts by means of DNA microarray analysis. Transplantation 72 (2001) 320
25. Brandacher G., Maglione M., Schneeberger S., et al. Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity. Transplantation 81 (2006) 583
26. Amuchastegui S., Daniel K.C., and Adorini L. Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist. Transplantation 80 (2005) 81
27. Pilzer D., and Fishelson Z. Mortalin/GRP75 promotes release of membrane vesicles from immune-attacked cells and protection from complement-mediated lysis. Int Immunol 17 (2005) 1239
28. Jayakumar J., Suzuki K., Khan M., et al. Gene therapy for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury. Circulation 102 19 suppl 3 (2000) III302
29. Jayakumar J., Suzuki K., Sammut I.A., et al. Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. Circulation 104 12 suppl 1 (2001) I303
30. Tsui T.Y., Wu X., Lau C.K., et al. Prevention of chronic deterioration of heart allograft by recombinant adeno-associated virus-mediated heme oxygenase-1 gene transfer. Circulation 107 (2003) 2623
31. Braudeau C., Bouchet D., Tesson L., et al. Induction of long-term cardiac allograft survival by heme oxygenase-1 gene transfer. Gene Ther 11 (2004) 701
32. Imamura M., Tsutsumi Y., Miura Y., et al. Immune reconstitution and tolerance after allogeneic hematopoietic stem cell transplantation. Hematology 8 (2003) 19
33. Aguilar P., Mathieu C.P., Clerc G., et al. Modulation of natural killer (NK) receptors on NK (CD3-/CD56+), T (CD3+/CD56-) and NKT-like (CD3+/CD56+) cells after heart transplantation. J Heart Lung Transplant 25 (2006) 200
34. Sato Y., Ichida T., Watanabe H., et al. Macrochimerism of donor type CD56+ CD3+ T cells in donor specific transfusion via portal vein following living related donor liver transplantation. Hepatogastroenterology 50 (2003) 2161
35. Cookson S., Doherty D.G., Todryk S., et al. Hepatic expression of IL-15 mRNA is associated with liver graft acceptance. Transpl Immunol 11 (2003) 39
36. Abraham E. Akt/protein kinase B. Crit Care Med 33 12 suppl (2005) S420
37. Matsui T., and Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 38 (2005) 63
38. Kovacina K.S., Park G.Y., Bae S.S., et al. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem 278 (2003) 10189
39. Matsui T., Li L., del Monte F., et al. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100 (1999) 2373
40. Matsui T., Tao J., del Monte F., et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104 (2001) 330
41. Huang B., and Porter G. Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. Acta Pharmacol Sin 26 (2005) 1253
42. Chan P.H. Future targets and cascades for neuroprotective strategies. Stroke 35 11 suppl 1 (2004) 2748
43. Jin S.L., and Conti M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proc Natl Acad Sci U S A 99 (2002) 7628
44. Jin S.L., Lan L., Zoudilova M., et al. Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. J Immunol 175 (2005) 1523
45. Ariga M., Neitzert B., Nakae S., et al. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J Immunol 173 (2004) 7531
46. Schade I., Roth-Eichhorn S., Kasper M., et al. Benefit of phosphodiesterase-4 inhibitors as supplemental therapy after lung transplantation concerning their antiproliferative effects: an experimental study using a heterotopic rodent model. Transplantation 74 (2002) 326
47. Korom S., De Meester I., Stadlbauer T.H., et al. Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients. Transplantation 63 (1997) 1495
48. Christopherson K.W., Hangoc G., Mantel C.R., et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 305 (2004) 1000
49. Tian C., Bagley J., Forman D., et al. Inhibition of CD26 peptidase activity significantly improves engraftment of retrovirally transduced hematopoietic progenitors. Gene Ther 13 (2006) 652
50. Dominguez-Soto A., Puig-Kroger A., Vega M.A., et al. PU.1 regulates the tissue-specific expression of dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin. J Biol Chem 280 (2005) 33123