Highly flexible and efficient synthesis of the GABAB enhancer 4-(2-hexylsulfanyl-6-methyl-pyrimidin-4-ylmethyl)-morpholine

Tetrahedron Letters

Volumn 48, Issue 3, 2007, Pages 377-380

  Verron, Julien ^a   Malherbe, Paricher ^a   Prinssen, Eric ^a   Thomas, Andrew W ^a   Nock, Nadine ^a   Masciadri, Raffaello ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

2,4,6 Substituted pyrimidines; 2 Hexyl isothiourea hydrobromide; 5,5 Diethoxy pent 3 yn 2 one; GABAB enhancer; Modular pyrimidine synthesis

Indexed keywords

2 HEXYLISOTHIOUREA HYDROBROMIDE; 4 [(2 HEXYLSULFANYL 6 METHYLPYRIMIDIN 4 YL)METHYL]MORPHOLINE; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 DIETHOXYMETHYL 2 HEXYLSULFANYL 6 METHYLPYRIMIDINE; BROMINE DERIVATIVE; MORPHOLINE DERIVATIVE; PYRIMIDINE DERIVATIVE; REAGENT; TETRAHYDROFURAN; THIOUREA DERIVATIVE; TRIETHYLAMINE;

ARTICLE; CHEMICAL REACTION; ENVIRONMENTAL TEMPERATURE; HEAT; SUBSTITUTION REACTION; SYNTHESIS;

EID: 33845396848     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.11.090     Document Type: Article

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