One-pot synthesis of new heterocycles: 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines

Tetrahedron Letters

Volumn 44, Issue 10, 2003, Pages 2149-2151

  Herrera, Antonio ^a   Martínez Alvarez, Roberto ^a   Chioua, Rachid ^a,b   Chioua, Mourad ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b FACULTÉ DES SCIENCES   (Morocco)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZOSUBERONE; ACID ANHYDRIDE; BENZENE DERIVATIVE; HETEROCYCLIC COMPOUND; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ELIMINATION REACTION; REACTION ANALYSIS;

EID: 0037416857     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00160-6     Document Type: Article

References (10)

1. Afonso, A.; Kelly, J. M.; Weinstein, J.; Wolin, R. L.; Rosenblum, S. B. US Patent 6 218 401, 2001; Chem. Abstr. 2001, 134, 295746.
2. Benoit J., Alagille D., Merour J.-Y., Leonce S. Chem. Pharm. Bull. 48:2000;1872.
3. Remiszewski, S. W.; Doll, R. J.; Alvarez, C.; Lalwani, T. US Patent 6 211 193, 2001; Chem. Abstr. 2001, 134, 266206.
4. Sasaki K., Arimoto Y., Ohtomo H., Nakayama T., Takashi H. J. Heterocylic Chem. 30:1993;989.
5. García Martínez A., Herrera Fernández A., Moreno Jiménez F., Subramanian L.R., Hanack M. J. Org. Chem. 57:1992;1627.
6. Herrera A., Martínez-Alvarez R., Ramiro P., Chioua M., Torres R. Tetrahedron. 58:2002;3755.
7. Katrizky A., Rees C.W. Comprehensive Heterocyclic Chemistry. 3:1984;503 Pergamon Press, Oxford.
8. Martínez A.G., Herrera A., Jiménez F.M., Luengo M.J., Subramanian L.R. Synlett. 1994;559.
9. 3 and the organic layer extracted with dichloromethane. After drying and evaporation of the solvent, the residue is recrystallized in the appropriate solvent.
10. 2: C, 86.10; H, 6.98; N, 6.92%. Found: C, 85.63; H, 7.06; N, 7.04.