Chronic contamination with 137cesium in rat: Effect on liver cholesterol metabolism

International Journal of Toxicology

Volumn 25, Issue 6, 2006, Pages 493-497

  Souidi, M ^a   Tissandie, E ^a   Grandcolas, L ^a   Grison, S ^a   Paquet, F ^a   Voisin, P ^a   Aigueperse, J ^a   Gourmelon, P ^a   Gueguen Y ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

Cesium; Chernobyl; Cholesterol; Liver; Rat

Indexed keywords

ABC TRANSPORTER A1; ABCG5 PROTEIN; APOLIPOPROTEIN B; CESIUM 137; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; ABC TRANSPORTER; ABCG5 PROTEIN, RAT; CELL RECEPTOR; CESIUM; CHOLESTEROL; DNA BINDING PROTEIN; LIPOPROTEIN; LIVER X RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CHERNOBYL ACCIDENT; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENDOCRINE DISEASE; FOOD CONTAMINATION; GENE EXPRESSION REGULATION; LIPIDOSIS; LIVER METABOLISM; LIVER TOXICITY; MALE; MOLECULAR BIOLOGY; NONHUMAN; RADIATION HAZARD; RADIOACTIVE CONTAMINATION; RAT; RECEPTOR BINDING; THYROID CANCER; ANIMAL; BLOOD; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; LIVER; LIVER MICROSOME; LIVER MITOCHONDRION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; APOLIPOPROTEINS B; ATP-BINDING CASSETTE TRANSPORTERS; CESIUM RADIOISOTOPES; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 CYP27A1; DNA-BINDING PROTEINS; GENE EXPRESSION; LIPOPROTEINS; LIVER; MALE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LDL; RNA, MESSENGER;

EID: 33845367927     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810600961317     Document Type: Article

References (30)

1. Bandazhevskaya, G. S., V. B. Nesterenko, V. I. Babenko, T. V. Yerkovich, and Y. I. Bandazhevsky. 2004. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in 'Chernobyl' children - preliminary observations after intake of oral apple pectin. Swiss. Med. Wkly. 134:725-729.
2. Boehler, N., M. Riottot, J. Ferezou, M. Souidi, F. Milliat, C. Serougne, J. L. Smith, and C. Lutton. 1999. Antilithiasic effect of beta-cyclodextrin in LPN hamster: Comparison with cholestyramine. J. Lipid. Res. 40:726-734.
3. Bussy, C., P. Lestaevel, B. Dhieux, C. Amourette, F. Paquet, P. Gourmelon, and P. Houpert. 2006. Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain. Neurotoxicology 27:245-252.
4. Chaialo, P. P., G. M. Chobot'ko, I. V. Shimelis, and B. P. Prevarskii. 1991. [Content of blood lipids and characteristics of dyslipoproteinemias in people exposed to radiation during the accident at the Chernobyl nuclear power station]. Ukr. Biokhim. Zh. 63:93-96.
5. Cheburakov, BIu., SIu. Cheburakov, and NIu. Belozerov. 2004. [Morphological changes in testicular tissue in clean-up personnel after the Chernobyl nuclear reactor accident]. Arkh. Patol. 66:19-21.
6. Cherenko, S. M., O. S. Larin, M. B. Gorobeyko, and R. M. Sichynava. 2004. Clinical analysis of thyroid cancer in adult patients exposed to ionizing radiation due to the Chernobyl nuclear accident: 5-Year comparative investigations based on the results of surgical treatment. World J. Surg. 28:1071-1074.
7. Dehtiar'ova, L. V., and T. H. Kozlova. 2001. [Morphofunctional characteristics of secretion-producing structures of the gastric and duodenal mucosa in liquidators of aftermaths of the Chernobyl accident with peptic ulcer of the duodenum]. Lik. Sprava. (1):19-23.
8. Feurgard, C., N. Boehler, J. Ferezou, C. Serougne, J. Aigueperse, P. Gourmelon, C. Lutton, and D. Mathe. 1999. Ionizing radiation alters hepatic cholesterol metabolism and plasma lipoproteins in Syrian hamster. Int. J. Radiat. Biol. 75:757-766.
9. Fritz, T. E. 1972. Cesium 137 late effects of single intravenous injections in beagles. In ANL 7970, Argone National Laboratory Annual Report 206-208.
10. Goncharov, N. P., G. V. Katsiya, G. S. Kolesnikova, G. A. Dobracheva, T. N. Todua, V. V. Vax, A. Giwercman, and G. M. Waites. 1998. Endocrine and reproductive health status of men who had experienced short-term radiation exposure at Chernobyl. Int. J. Androl. 21:271-276.
11. Gueguen, Y., M. Souidi, C. Baudelin, N. Dudoignon, S. Grison, I. Dublineau, C. Marquette, P. Voisin, P. Gourmelon, and J. Aigueperse. 2006. Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Arch. Toxicol. 80(4):187-195.
12. Handl, J., D. Beltz, W. Botsch, S. Harb, D. Jakob, R. Michel, and L. D. Romantschuk. 2003. Evaluation of radioactive exposure from 137Cs in contaminated areas of Northern Ukraine. Health Phys. 84:502-517.
13. Ivanov, V. K., M. A. Maksioutov, SYu Chekin, Z. G. Kruglova, A. V. Petrov, and A. F. Tsyb. 2000. Radiation-epidemiological analysis of incidence of non-cancer diseases among the Chernobyl liquidators. Health Phys. 78:495-501.
14. Lestaevel, P., B. Dhieux, E. Tourlonias, P. Houpert, F. Paquet, P. Voisin, J. Aigueperse, and P. Gourmelon. 2006. Evaluation of the effect of chronic exposure to 137Cs on sleep-wake cycle in rats. Toxicology. 226(2-3):118-125.
15. Lestaevel, P., P. Houpert, C. Bussy, B. Dhieux, P. Gourmelon, and F. Paquet. 2005. The brain is a target organ after acute exposure to depleted uranium. Toxicology 212:219-226.
16. Libby, P., M. Aikawa, and U. Schonbeck. 2000. Cholesterol and atherosclerosis. Biochim. Biophys. Acta 1529:299-309.
17. Likhtarov, I., L. Kovgan, S. Vavilov, M. Chepurny, A. Bouville, N. Luckyanov, P. Jacob, P. Voilleque, and G. Voigt. 2005. Post-Chornobyl thyroid cancers in Ukraine. Report 1: Estimation of thyroid doses. Radiat. Res. 163:125-136.
18. Liubchenko, P. N., L. I. Kovaleva, A. P. Nikolaeva, E. A. Bendikov, E. B. Dubinina, and V. A. Ol'shanskii. 1994. [Intrahepatic circulation in participants of clean-up after the Chernobyl Atomic Energy Plant accident]. Med. Tr. Prom. Ekol. (2):15-17.
19. Nikula, K. J., B. A. Muggenburg, W. C. Griffith, W. W. Carlton, T. E. Fritz, and B. B. Boecker. 1996. Biological effects of 137CsCl injected in beagle dogs of different ages. Radiat. Res. 146:536-547.
20. Norris, W. P., C. M. Poole, and C. E. Rehfeld. 1966. Cesium 137 - Current status and dosimetry of survivors. In Toxicity and Dosimetry of Radionuclides, ANL 7278, 98-101.
21. Ory, D. S. 2004. Nuclear receptor signaling in the control of cholesterol homeostasis: Have the orphans found a home? Circ. Res. 95:660-670.
22. Pinchuk, V. G., V. V. Nikitchenko, BIa Gol'dshmid, L. I. Andrushchak, and I. Serkiz 1991. [The biological effects in animals related to the accident at the Chernobyl Atomic Electric Power Station. 4. The morphological and ultrastructural changes in the liver of rats]. Radiobiologiia 31:648-653.
23. Scanff, P., M. Souidi, S. Grison, N. M. Griffiths, and P. Gourmelon. 2004. Alteration of the enterohepatic recirculation of bile acids in rats after exposure to ionizing radiation. Can. J. Physiol. Pharmacol. 82:114-124.
24. Shkala, L. V. 1998. [Metabolic disorders in digestive and hepatobiliary pathology in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. Lik. Sprava. (7):42-45.
25. Souidi, M., Y. Gueguen, C. Linard, N. Dudoignon, S. Grison, C. Baudelin, C. Marquette, P. Gourmelon, J. Aigueperse, and I. Dublineau. 2005. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. Toxicology 214:113-122.
26. Souidi, M., M. Parquet, J. Ferezou, and C. Lutton. 1999. Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster. Life Sci. 64:1585-1593.
27. Stojadinovic, S., and M. Jovanovic. 1966. Activity of transaminases in the rat serum after internal contamination with 137Cs and 90Sr. Strahlentherapie 131:633-636.
28. Tissandie, E., Y. Gueguen, J. M. Lobaccaro, J. Aigueperse, P. Gourmelon, F. Paquet, and M. Souidi. 2006a. Chronic contamination with (137)cesium affects vitamin D(3) metabolism in rats. Toxicology. 80(8):173-480.
29. Tissandie, E., Y. Gueguen, J. M. Lobaccaro, F. Paquet, J. Aigueperse, and M. Souidi. 2006b. Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat. Arch. Toxicol. In Press.
30. Ulven, S. M., K. T. Dalen, J. A. Gustafsson, and H. I. Nebb. 2005. LXR is crucial in lipid metabolism. Prostaglandins. Leukot. Essent. Fatty Acids. 73:59-63.