The protective effects of phenolic constituents from Gastrodia elata on the cytotoxicity induced by KCl and glutamate

Archives of Pharmacal Research

Volumn 29, Issue 11, 2006, Pages 963-968

  Huang, Zhan Bo ^a   Wu, Zhe ^a   Chen, Fa Kui ^a   Zou, Li Bo ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Gastrodia elata; MTT assay; Neuroprotection; PC12 cells; Phenolic constituents

Indexed keywords

EID: 33845355509     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02969279     Document Type: Article

References (21)

1. Andersson, M., Bergendorff, O., Nielsen, M., Sterner, O., Witt, R., Ai, J. L., Liu, A. P., and Wang, A. M., Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry, 38, 835-836 (1995).
2. Ha, J. H., Lee, D. U., Lee, J. T., Kim, J. S., Yong, C. S., Kim, J. A., Ha, J. S., and Huh, K., 4-Hydroxybenxaldehyde from Gastrodia elata Bl. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J. Ethnopharmacol., 73, 329-333 (2000).
3. Hayashi, J., Sekine, T., Deguchi, S., Lin, Q., Horie, S., Tsuchiya, S., Yano, S., Watanabe, K., and Ikegami, F., Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds no isolated smooth muscle preparation. Phytochemistry, 59, 513-519 (2002).
4. Hsieh, C. L., Tang, N. Y., Chiang, S. Y., Hsieh, C. T., and Lin, J. G., Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophyllia (MIQ) Jacks and Gastrodia elata Bl., in kainic acid-treated rats. Life sci., 65, 2071-2082 (1999).
5. Huang, N. K., Lin, Y. L., Chen, J. J., and Lai, W. L., Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life sci., 75, 1649-1657 (2004).
6. Huang, Z. B., Song, D. M., and Chen, F. K., Study on chemical constituents isolated from Gastrodia elata Bl. Chinese Journal of Medicinal Chemistry, 15, 227-229 (2005).
7. Huh, K., Yi, S. J., Shin, U. S., and Park, J. M., Effect of the ether of Gastrodia elata methanol extract on the pentylenetetrazole-induced seizures. Journal of Applied pharmacology, 3,199-204 (1995).
8. Jung, J. W., Yoon, B. H., Oh, H. R., Ahn, J. H., Kim, S. Y., Park, S. Y., and Ryu, J. H., Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol. Pharm. Bull., 29, 261-265 (2006).
9. Kim, H. J., Moon, K. D., Lee, D. S., and Lee, S. H., Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptide-induced cell death. J. Ethnopharmacol., 84, 95-98 (2003).
10. Kim, H. J., Moon, K. D., Oh, S. Y., Kim, S. P., and Lee, S. R., Ethyl ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci. Lett., 314, 65-68 (2001).
11. Lee, Y. S., Ha, J. H., Yong, C. S., Lee, D. U., Huh, K., Kang, Y. S., Lee, S. H., Jung, M. W., and Kim, J. A., Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells. Arch. Pharm. Res., 22, 404 (1999).
12. Liu, J. and Mori, A., Antioxidant and free radical scavenging activities of Gastrodia elata Bl. and Unicaria rhynchophylla (MIQ) Jacks. Neuropharmacology, 31, 1287-1298 (1992).
13. Liu, J. and Mori, A., Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA. Neuropharmacology, 32, 659 (1993).
14. Sun, X. F., Wang, W., Wang, D. Q., and Du, G. Y., Research progress of neuroprotective mechanisms of Gastrodia elata and its preparation. Zhongguo Zhong Yao Za Zhi, 29, 292-295 (2004).
15. Wu, H. Q., Xie, L., Jin, X. N., Ge, Q., Jin, H., and Liu, G. Q., The effect of Vanillin on the fully amygdale-kindled seizures in the rat. Yao Xue Xue Bao, 24, 482-486 (1989).
16. Wu, C. R., Hsieh, M. T., Huang, S. C., Peng, W. H., Chang, Y. S., and Chen, C. F., Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. Planta medica., 62, 317-321 (1996).
17. Vaňková, R., Gaudinová, A., Süssenbeková , H., Dobrev, P., Strnad, M., Holík, J., and Lenfeld, J., Comparison of oriented and random antibody immobilization in immunoaffinity chromatography of cytokinins. J. Chromato. A., 811, 77-84 (1998).
18. Yu, D. S., Duan, Y. L., Bao, Y. M., Wei, C. L., and An, L. J., Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate. J. Ethnopharmacol., 98, 89-94 (2005a)
19. Yu, S. J., Kim, J. R., Lee, C. K., Han, J. E., Lee, J. H., Kim, H. S., Hong, J. H., and Kang, S. G., Gastrodia elata Blume and an Active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol. Pharm. Bull., 28, 1016-1020 (2005b).
20. Yu, D. Q. and Yang J. S., Hand book of analytical chemistry (The Seventh Volume). Beijing: Chemical Industry Press, 7, 908 (1999).
21. Zhou, J., Yang, Y. B., and Pu, X. Y., The phenolic compounds of fresh Gastrodia elata blume. Yunnan Zhi Wu Yan Jiu, 2, 370-374 (1980).