Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli

Journal of Antimicrobial Chemotherapy

Volumn 58, Issue 6, 2006, Pages 1283-1286

  Zhao, Xilin ^a   Quinn, Brian ^a   Kerns, Robert ^b   Drlica, Karl ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Fluoroquinolones; Gyrase; Topoisomerase IV

Indexed keywords

7,7' [2 BUTENE 1,4 DIYLDI 4,1 PIPERAZINEDIYL]CIPROFLOXACIN; CIPROFLOXACIN; DIMER; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE IV; PROTEIN PARC;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; BACTERIUM MUTANT; CROSS LINKING; DIMERIZATION; DRUG STRUCTURE; DRUG TARGETING; ESCHERICHIA COLI; GENE MUTATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CIPROFLOXACIN; COLONY COUNT, MICROBIAL; DIMERIZATION; DNA GYRASE; DNA TOPOISOMERASE IV; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MUTATION; PIPERAZINES; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCUS AUREUS;

EID: 33845354723     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl388     Document Type: Article

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