Ethyl glucuronide and ethyl sulphate determination in serum by liquid chromatography-electrospray tandem mass spectrometry

Clinica Chimica Acta

Volumn 376, Issue 1-2, 2007, Pages 213-219

  Morini, Luca ^a   Politi, Lucia ^a   Zucchella, Alessandra ^a   Polettini, Aldo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Ethyl glucuronide; Ethyl sulphate; LC ESI MS MS; Serum

Indexed keywords

ALCOHOL DERIVATIVE; ETHYL SULFATE; ETHYLGLUCURONIDE; GLUCURONIDE; SULFATE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; DELAYED DIAGNOSIS; DIAGNOSTIC ACCURACY; DRINKING BEHAVIOR; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; ION MONITORING; LIQUID CHROMATOGRAPHY; OBSERVATIONAL METHOD; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; QUALITY CONTROL; VALIDATION PROCESS;

ALCOHOL DRINKING; ALCOHOLISM; CHROMATOGRAPHY, LIQUID; GLUCURONATES; HUMANS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFURIC ACID ESTERS;

EID: 33845333845     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2006.08.024     Document Type: Article

References (25)

1. Schmitt I., Aderjan R., Keller T., and Wu M. Ethyl glucuronide: an unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. J Anal Toxicol 19 (1995) 91-94
2. Janda I., and Alt A. Improvement of ethyl glucuronide determination in human urine and serum samples solid phase extraction. J Chromatogr B Biomed Sci Appl 758 (2001) 229-234
3. Zimmer H., Schmitt I., and Aderjan R. Preliminary immunochemical test for the determination of ethyl glucuronide in serum and urine: comparison of screening method results with gas chromatography-mass spectrometry. J Anal Toxicol 26 (2002) 11-16
4. Goll M., Schmitt I., Ganssmann B., and Aderjan E. Excretion profiles of ethyl glucuronide in human urine after internal dilution. J Anal Toxicol 26 (2002) 262-266
5. Stephanson N., Dahl H., Helander A., and Beck O. Direct quantification of ethyl glucuronide in clinical urine samples by liquid chromatography-mass spectrometry. Ther Drug Monit 24 (2002) 645-651
6. Bergstrom J., Helander A., and Jones A.W. Ethyl glucuronide concentrations in two successive urinary voids from drinking drivers: relationship to creatinine content and blood and urine ethanol concentrations. Forensic Sci Int 133 (2003) 86-94
7. Helander A., and Beck O. Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans. Clin Chem 50 (2004) 936-937
8. Dresen S., Weinmann W., and Wurst F.M. Forensic confirmatory analysis of ethyl sulfate - a new marker for alcohol consumption - by liquid-chromatography/electrospray ionization/tandem mass spectrometry. J Am Soc Mass Spectrom 15 (2004) 1644-1648
9. Politi L., Morini L., Groppi A., Poloni V., Pozzi F., and Polettini A. Direct determination of the ethanol metabolites ethyl glucuronide and ethyl sulfate in urine by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 19 (2005) 1321-1331
10. Schloegl H., Dresen S., Spaczynski K., Stoertzel M., Wurst F.M., and Weinmann W. Stability of ethyl glucuronide in urine, post-mortem tissue and blood samples. Int J Legal Med 30 (2005) 1-6
11. Kaushik R., LaCourse W.R., and Levine B. Determination of ethyl glucuronide in urine using reversed-phase HPLC and pulsed electrochemical detection (part II). Anal Chim Acta 556 (2006) 267-274
12. Skopp I., Schmitt I., Pötsch L., Drönner P., Aderjan R., and Mattern R. Ethyl glucuronide in human hair. Alcohol Alcohol 35 (2000) 283-285
13. Alt A., Janda I., Seidl S., and Wurst F.M. Determination of ethyl glucuronide in hair samples. Alcohol Alcohol 35 (2000) 313-314
14. Janda I., Weinmann W., Kuehnle T., Lahode M., and Alt A. Determination of ethyl glucuronide in human hair by SPE and LC-MS/MS. Forensic Sci Int 128 (2002) 59-65
15. Jurado C., Soriano T., Giménez M.P., and Menéndez M. Diagnosis of chronic alcohol consumption. Hair analysis for ethyl-glucuronide. Forensic Sci Int 145 (2004) 161-166
16. Yegles M., Labarthe A., Auwarter V., et al. Comparison of ethyl glucuronide and fatty acid ethyl ester concentrations in hair of alcoholics, social drinkers and teetotalers. Forensic Sci Int 145 (2004) 167-173
17. Klys M., Scislowski M., Rojek S., and Kolodziej J. A fatal clomipramine intoxication case of chronic alcoholic patient: application of postmortem hair analysis method of clomipramine and ethyl glucuronide using LC/APCI/MS. Leg Med (Tokyo) 7 (2005) 319-325
18. Morini L., Politi L., Groppi A., Stramesi C., and Polettini A. Determination of ethyl glucuronide in hair samples by liquid chromatography/electrospray tandem mass spectrometry. J Mass Spectrom 41 (2006) 34-42
19. Schmitt I., Droenner P., Skopp G., and Aderjan R. Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers. J Forensic Sci 42 (1997) 1099-1102
20. Nishikawa M., Tsuchihashi H., Miki A., et al. Determination of ethyl glucuronide, a minor metabolite of ethanol, in human serum by liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr B Biomed Sci Appl 726 (1999) 105-110
21. Krivankova L., Caslavska J., Malaskova H., Gebauer P., and Thormann W. Analysis of ethyl glucuronide in human serum by capillary electrophoresis with sample self-staking and indirect detection. J Chromatogr A 1081 (2005) 2-8
22. Høiseth G, Karinen R, Christophersen AS, Olsen L, Normann PT, Mørland J. A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol. Forensic Sci Int.; article in press.
23. Wurst F.M., Skipper G.E., and Weinmann W. Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98 (2003) 51-61
24. Wurst F.M., Dresen S., Allen J.P., Wiesbeck G., Graf M., and Weinmann W. Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption. Addiction 101 (2006) 204-211
25. Halter CC, Dresen S, Wurst FW, Buehler P, Weinmann W. Ethyl phosphate: another marker for ethanol consumption besides ethyl glucuronide and ethyl sulfate detected by LC-MS/MS in urine. 43rd Meeting of the International Association of Forensic Toxicology (TIAFT), Seoul, August 29-September 2, 2005, Abstract Book, Oral Session 5.