Statin therapy-evidence beyond lipid lowering contributing to plaque stability

Current Medicinal Chemistry

Volumn 13, Issue 28, 2006, Pages 3385-3393

  de Lorenzo, Ferruccio ^a,b   Feher, Michael ^b   Martin, Juliette ^a   Collot Teixeira, Sophie ^a   Dotsenko, Olena ^a   McGregor, John Louis ^a,c,d  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Coronary heart disease; Lipid lowering agents; Plaque stability; Pleiotropic effects; Statins; Thrombosis

Indexed keywords

ATORVASTATIN; BEZAFIBRATE; CD36 ANTIGEN; CERIVASTATIN; CLOFIBRATE; COLESTYRAMINE; DEXTROTHYROXINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; EZETIMIBE; FENOFIBRATE; FLUINDOSTATIN; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MATRIX METALLOPROTEINASE; MEVINOLIN; NICOTINIC ACID; PITAVASTATIN; PLACEBO; PRAVASTATIN; RAMIPRIL; ROSUVASTATIN; SIMVASTATIN; TELMISARTAN; THROMBOPLASTIN; TIROFIBAN; UNINDEXED DRUG;

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DISEASE CONTROL; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE REGIMEN; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEART INFARCTION; HUMAN; HYPERLIPIDEMIA; ISCHEMIC HEART DISEASE; LIPID OXIDATION; MACROPHAGE FUNCTION; MONOTHERAPY; MORTALITY; NONHUMAN; PLEIOTROPY; PROTEIN EXPRESSION; REVIEW; RISK REDUCTION; SINGLE DRUG DOSE; THROMBOSIS; TREATMENT DURATION;

ARTERIOSCLEROSIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA;

EID: 33845331060     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706779010324     Document Type: Review

References (77)

1. Liao, J.K.; Laufs, U. Annu. Rev. Pharmacol. Toxicol., 2005, 45, 89.
2. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. JAMA, 1984, 251, 365.
3. Buchwald, H.; Varco, R.L.; Matts, J.P.; Long, J.M.; Fitch, L.L.; Campbell, G.S.; Pearce, M.B.; Yellin, A.E.; Edmiston, W.A.; Smink, R.D. N. Engl. J. Med., 1990, 323(14), 946-55.
4. Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results, I. JAMA, 1984, 251, 351.
5. Stamler, J. Adv. Exp. Med. Biol., 1977, 82, 52.
6. Canner, P.L.; Berge, K.G.; Wenger, N.K.; Stamler, J.; Friedman, L.; Prineas, R,J.; Friedewald, W. J. Am. Coll. Cardiol., 1986, 8, 1245.
7. Carlson, L.A.; Rosenhamer, G. Acta Med. Scand., 1988,223,405.
8. Carlson, L.A.; Danielson, M.; Ekberg, L; Klintemar, B.; Rosenhamer, G. Atherosclerosis, 1977, 28, 81-86.
9. Frick, M.H.; Heinonen, O.P.; Huttunen, J.K.; Koskinen, P.; Manttari, M.; Manninen, V. Ann. Med., 1993, 25, 41.
10. Rubins, H.B.; Robins, S.J.; Collins, D.; Fye, C.L.; Anderson, J,W.; Elam, M.B.; Faas, F.H.; Linares, E.; Schaefer, E.J.; Schectman, G.; Wilt, T.J.; Wittes, J. N. Engl. J. Med., 1999, 341, 410.
11. BIP Study Group. Circulation; 2000, 102, 21.
12. Keech, A.; Simes, R.J.; Barter, P.; Best, J.; Scott, R.; Taskinen, M.R.; Forder, P.; Pillai, A.; Davis, T.; Glasziou, P.; Drury, P.; Kesaniemi, Y.A.; Sullivan, D.; Hunt, D.; Colman, P.; d'Emden, M.; Whiting, M.; Ehnholm, C.; Laakso, M.; FIELD study investigators. Lancet, 2005, 366,1849.
13. Heart Protection Study Collaborative Group. Lancet, 2002, 360, 7.
14. Sever, P.S.; Dahlof, B.; Poulter, N.R.; Wedel, H.; Beevers, G.; Caulfield, M.; Collins, R.; Kjeldsen, S.E.; Kristinseon, A.; McInnes, G.T.; Mehlsen, J.; Nierninen, M.; O'Brien, E.; Ostergren, J.; ASCOT investigators. Lancet, 2003, 361, 1149.
15. Shepherd, J.; Cobbe, S.M.; Ford, I.; Isles, C.G.; Lorimer, A.R.; MacFarlane, P.W.; McKillop, J.H.; Packard, C.J. N. Engl. J. Med., 1995, 333, 1301.
16. Sacks, F.M.; Pfeffer, M.A.; Moye, L.A.; Rouleau, J.L.; Rutherford, J.D.; Cole, T.G.; Brown, L.; Warnica, J.W.; Arnold, J.M.; Wun, C.C.; Davis, B.R.; Braunwald, E. N. Engl. J. Med., 1996, 335, 1001.
17. Shepherd, J.; Barter, P.; Carmens, R.; Deedwania, P.; Fruchart, J.C.; Haffner, S.; Hsia, J.; Breazna, A.; LaRosa, J.; Grundy, S.; Waters, D. Diabetes Care, 2006, 29, 1220.
18. Pekkanen, J.; Linn, S.; Heiss, G.; Suchindran, C.M.; Leon, A.; Rifkind, B.M.; Tyroler, H.A. N. Engl. J. Med., 1990, 322, 1700.
19. West of Scotland Coronary Prevention Study Group. Circulation, 1998, 97, 1440.
20. Nissen, S,E,; Tuzcu, E.M.; Schoenhagen, P.; Brown, B.G.; Ganz, P.; Vogel, R.A.; Crowe, T.; Howard, G.; Cooper, C.J.; Brodie, B.; Grines, C.L.; DeMaria, A.N.; REVERSAL Investigators. JAMA, 2004, 291, 1071.
21. Nissen, S.E.; Nicholls, S.J.; Sipahi, I.; Libby, P.; Raichlen, J.S.; Ballantyne, C.M.;, Davignon, J.; Erbel, R.; Fruchart, J.C.; Tardif, J.C.; Schoenhagen, P.; Crowe, T.; Cain, V.; Wolski, K.; Goormastic, M.; Tuzcu, E.M.; ASTEROID Investigators. JAMA, 2006, 295, 1556.
22. Davignon, J. Circulation, 2004, 109, III39.
23. Colhoun, H.M.; Betteridge, D.J.; Durrington, P.N.; Hitman, G.A.; Neil, H.A.; Livingstone, S.J.; Thomason, M.J.; Mackness, M.I.; Charlton-Menys, V.; Fuller, J.H.; CARDS investigators. Lancet, 2004, 364, 685.
24. Cannon C.P.; Braunwald, E.; McCabe, C.H.; Rader, D.J.; Rouleau, J.L.; Belder, R.; Joyal, S.V.; Hill, K.A.; Pfeffer, M.A.; Skene, A.M.; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. N. Engl. J. Med., 2004, 350, 1495.
25. de Lemos, J.A; Blazing, M.A.; Wiviott, S.D.; Lewis, E.F.; Fox, K.A.; White, H.D.; Rouleau, J.L.; Pederson, T.R.; Gardner, L.H.; Mukherjee, R.; Ramsey, K.E.; Palmisano, J.; Bilheimer, D.W.; Pfeffer, M.A.; Califf R.M.; Braunwald, E.; A to Z Investigators. JAMA, 2004, 292, 1307.
26. Tsiara, S.; Elisaf, M.; Mikhailidis, D.P., Curr. Med. Res. Opin., 2003, 19, 540.
27. Anderson, J.L.; Allen-Maycock C.A.; Lappe, D.L.; Crandall, B.G.; Home, B.D.; Bair, T.L.; Morris, S.R.; Li, Q.; Muhlestein, J.B.; Intermountain Heart Collaborative Study group. Am. J. Cardiol., 2004, 94, 1255.
28. Wassmann, S.; Faul, A.; Hennen, B.; Scheller, B.; Bohm, M.; Nickenig, G. Circ. Res., 2003, 93, 98.
29. Wolfrum, S.; Dendorfer, A.; Schutt, M.; Weidtmann, B.; Heep, A.; Tempel, K.; Klein, H.H.; Dominiak, P.; Richardt, G. J. Cardiovasc. Pharmacol., 2004, 44, 348.
30. Kinlay, S.; Schwartz, G.G.; Olsson, A.G.; Rifai, N.; Sasiela, W.J.; Szarek, M.; Ganz, P.; Libby, P.; Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Circulation, 2004, 110, 386.
31. Okazaki, S.; Yokoyama, T.; Miyauchi, K.; Shimada, K.; Kurata, T.; Sato, H.; Daida, H. Circulation, 2004, 110, 1061.
32. Schwartz, G.G.; Olsson, A.G.; Ezekowitz, M.P.; Ganz, P.; Oliver, M.F.; Waters, D.; Zeiher, A.; Chaitman, B.R.; Leslie, S.; Stern, T.; Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. JAMA, 2001, 285, 1711.
33. Kinlay, S.; Schwartz, G.G.; Olsson, A.G.; Rifai, N.; Leslie, S.J.; Sasiela, W.J.; Szarek, M.; Libby, P.; Ganz, P.; Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators. Circulation, 2003, 108, 1560.
34. Ballantyne, C.M.; Houri, J.; Notarbartolo, A.; Melani, L.; Lipka, L.J.; Suresh, R.; Sun, S, LeBeaut, A.P.; Sager, P.T.; Veltri, E.P.; Ezetimibe Study Group. Circulation, 2003, 107, 2409.
35. Sager, P.T.; Melani, L.; Lipka, L.; Strony, J.; Yang, B.; Suresh, R.; Veltri, E.; Ezetimibe Study Group. Am. J. Cardiol., 2003, 92, 1414.
36. Scandinavian Simvastatin Survival Study Oroup. Lancet, 1994, 344, 1383.
37. Ray, K.K.; Cannon, C.P. Crit. Pathways. Cardiol., 2005, 4, 1.
38. Pasceri, V.; Patti, G.; Nusca, A.; Pristipino, C.; Richichi, G.; Di Sciascio, G.; ARMYDA Investigators. Circulation, 2004, 110, 674.
39. Kannel, W.B.; Castelli, W.P.; Gordon, T.; McNamara, P.M. Ann. Intern. Med., 1971, 74, 1.
40. Multiple Risk Factor Intervention Trial Research Group. JAMA, 1982, 248, 1465.
41. Crouse, J.R.; Byington, R.P.; Furberg, C.D. Atherosclerosis, 1998, 138, 11.
42. Collins, R.; Armitage, J.; Parish, S.; Sleight, P.; Peto, R.; Heart Protection Study Collaborative Group. Lancet, 2004, 363, 757.
43. Fuster, V. Am. J. Cardiol., 1995, 76, 24C.
44. Fuster, V.; Stein, B.; Ambrose, J.A.; Badimon, L.; Badimon, J.J.; Chesebro, J.H. Circulation, 1990, 82, 1147.
45. Fukumoto, Y.; Libby, P.; Rabkin, E.; Hill, C.C.; Enomoto, M.; Hirouchi, Y.; Shiomi, M.; Aikawa, M. Circulation; 2001, 103, 993.
46. Koh, K.K. Cardiovasc. Res., 2000, 47, 648.
47. Aikawa, M.; Rabkin, E.; Sugiyama, S.; Voglic, S.J.; Fukumoto, Y.; Furukawa, Y, Shiomi, M.; Schoen, F.J.; Libby, P. Circulation, 2001, 103, 276.
48. Bourcier, T.; Libby, P. Arterioscler. Thromb. Vasc. Biol., 2000, 20, 556.
49. Crisby, M.; Nordin-Fredriksson, G.; Shah, P.K.; Yano, J.; Zhu, J.; Nilsson, J. Circulation, 2001, 103, 926.
50. Nissen, S.E. Am. J. Med., 2005, 118, 22S.
51. Tani, S.; Watanabe, I.; Anazawa, T.; Kawamata, H.; Tachibana, E.; Furukawa, K.; Sato, Y.; Nagao, K.; Kanmatsuse, K.; Kushiro, T.; Surugadai Atherosclerosis Regression Investigators. Am. J. Cardiol., 2005, 96, 1089.
52. Pietsch, A.; Erl, W.; Lorenz, R.L. Biochem. Pharmacol., 1996, 52, 433.,
53. Han, J.; Zhou, X.; Yokoyama, T.; Hajjar, D.P.; Gotto, A.M. Jr.; Nicholson, A.C. Circulation, 2004, 109, 790.
54. Fuhrman, B.; Koren, L.; Volkova, N.; Keidar, S.; Hayek, T.; Aviram, M. Atherosclerosis, 2002, 164, 179.
55. Hrboticky, N.; Draude, G.; Hapfelmeier, G.; Lorenz, R.; Weber, P.C. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 1267.
56. Llaverias, G.; Rebollo, A.; Pou, J.; Vazquez-Carrera, M.; Sanchez, R.M.; Laguna, J.C.; Alegtet, M. Biochem. Pharmacol., 2006, 71, 605.
57. Chmielewski, M.; Bryl, E.; Marzec, L.; Aleksandrowicz, E.; Witkowski, J.M.; Rutkowski, B. Artif. Organs., 2005, 29, 608.
58. Bruni, F.; Pasqui, A.L.; Pastorelli, M.; Bova, G.; Cercignani, M.; Palazzuoli, A.; Sawamura, T.; Auteri, A.; Puccetti, L. Clin. Appl. Thromb. Hemost., 2005, 11, 417.
59. Thum, T.; Fraccarollo, D.; Galuppo, P.; Tsikas, D.; Frantz, S.; Ertl, G.; Bauersachs, J. Cardiovasc. Res., 2006, 70, 50.
60. Grothusen, C.; Bley, S.; Selle, T.; Luchtefeld, M.; Grote, K.; Tietge, U.J.; Drexler, H.; Schieffer, B. Atherosclerosis, 2005, 182, 57.
61. Nomura, S.; Yoshimura, K.; Akiyama, N.; Mikamo, A.; Furutani, A.; Aoki, H.; Matsuzaki, M.; Hamano, K. Eur. Surg. Res., 2005, 37, 370.
62. Ozaki, H.; Miyashita, Y.; Watanabe, H.; Shirai, K. J. Atheroscler. Thromb., 2005, 12, 308.
63. Leu, H.B.; Chen, J.W.; Wu, T.C.; Ding, Y.A.; Lin, S.J.; Charng, M.J. Clin. Cardiol., 2005, 28, 423.
64. Furman, C.; Copin, C.; Kandoussi; M.; Davidson, R.; Moreau, M.; McTaggiart, F.; Chapman, M.J.; Fruchart, J.C.; Rouis, M. Atherosclerosis, 2004, 174, 93.
65. Mitani, H.; Egashira, K.; Kimura, M. Pharmacol. Res., 2003, 48, 417. -
66. Luan, Z.; Chase, A.J.; Newby, A.C. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 769.
67. Baetta, R.; Camera, M.; Comparato, C.; Altana, C.; Ezekowitz, M.D.; Tremoli, E. Arterioscler. Thromb. Vasc. Blol., 2002, 22, 692.
68. Kunieda, Y.; Nakagawa, K.; Nishimura, H.; Kato, H.; Ukimura, N.; Yano, S.; Kawano, H.; Kimura, S.; Nakagawa, M.; Tsuji, H. Thromb. Res., 2003, 110, 227.
69. Be, F.; Blessing, E.; Shelley, M.I.; Shultz, J.M.; Rosenfeld, M.E. Atherosclerosis, 2003, 167, 187.
70. Undas, A.; Brummel-Ziedins,K.E.; Mann, K.G. Arterioscler. Thromb. Vasc. Biol., 2005, 25, 287.
71. Hamilton, J.A.; Myers, D.; Jessup, W.; Cochrane, F.; Byrne, R.; Whitty, G.; Moss, S. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 98.
72. Paoletti, R.; Bellosta, S.; Bernini, F. Ann. N. Y. Acad Sci., 1997, 832, 322.
73. Aikawa, M.; Rabkin, E.; Sugiyama, S.; Voglic, S.J.; Fukumoto, Y.; Furukawa, Y.; Shiomi, M.; Schoen, F.J.; Libby, P. Circulation, 2001, 103, 276.
74. Fukumoto, Y.; Libby, P.; Rabkin, E.; Hill, C.C.; Enomoto, M.; Hirouchi, Y.; Shiomi, M.; Aikawa, M. Circulation, 2001, 103, 993.
75. Sakai, M.; Kobori, S.; Matsumura, T.; Biwa T.; Sato, Y.; Takemura, T.; Hakamata, H.; Horiuchi, S.; Shichiri, M. Atherosclerosis, 1997, 133, 51.
76. Shiomi, M.; Yamada, S.; Ito, T. Atherosclerosis, 2005, 178, 287.
77. Mason, R.P.; Walter, M.F.; Day, C.A.; Jacob, R.F. Am. J. Cardiol., 2005, 96, 11F.