The tobacco industry's role in the 16 Cities Study of secondhand tobacco smoke: Do the data support the stated conclusions?

Environmental Health Perspectives

Volumn 114, Issue 12, 2006, Pages 1890-1897

  Barnes, Richard L ^a   Hammond, S Katharine ^b   Glantz, Stanton A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1,6 Cities Study; Center for Indoor Air Research; Environmental tobacco smoke; ETS; Occupational Safety Health Administration; OSHA; R.J. Reynolds Tobacco Co.; Roger Jenkins; Secondhand tobacco smoke

Indexed keywords

TOBACCO SMOKE;

ARTICLE; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; MEDICAL RESEARCH; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OCCUPATIONAL HEALTH; PASSIVE SMOKING; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; RESIDENTIAL HOME; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SMOKING CESSATION PROGRAM; TOBACCO INDUSTRY; UNITED STATES; URBAN AREA; VALIDITY; WORKPLACE;

CITIES; HUMANS; OCCUPATIONAL EXPOSURE; PUBLIC HEALTH; TOBACCO INDUSTRY; TOBACCO SMOKE POLLUTION; UNITED STATES; WORKPLACE;

NICOTIANA TABACUM;

EID: 33845306436     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9385     Document Type: Article

References (115)

1. Bailey A. 1993. Letter to Max Eisenberg re 1993 Air Quality Study. 19930211. Bates No. 510637680. Available: http://legacy.library.ucsf.edu/ tid/jgz53d00 [accessed 14 September 2004].
2. Barnes D, Bero L. 1996. Industry-funded research and conflict of interest: An analysis of research sponsored by the tobacco industry through the Center for Indoor Air Research. J Health Polit Policy Law 21:515-542.
3. Barnes D, Bero L. 1997. Scientific quality of original research articles on environmental tobacco smoke. Tob Control 6:19-26.
4. Barnes D, Bero L. 1998. Why review articles on the health effects of passive smoking reach different conclusions. JAMA 279:1566-1570.
5. Barnes D, Hanauer P, Slade J, Bero L, Glantz S. 1995. Environmental tobacco smoke. The Brown and Williamson documents. JAMA 274:248-253.
6. Barnoya J, Glantz S. 2002. Tobacco industry success in preventing regulation of secondhand smoke in Latin America: The "Latin Project." Tob Control 11:305-314.
7. Barnoya J, Glantz S. 2005. The tobacco industry's worldwide ETS consultants project: European and Asian components. Eur J Public Health 16:69-77.
8. Bekelman J, Li Y, Gross C. 2003. Scope and Impact of Financial Conflicts of Interest in Biomedical Research. JAMA 289:454-465.
9. Bellomy Research. 1993a. Home Diary. 19930406. Bates No. 2023522306/ 2307. Available: http://legacy.library.ucsf.edu/tid/tfs78e00 [accessed 14 September 2004].
10. Bellomy Research. 1993b. Workplace Diary. 19930331. Bates No. 2023522304/ 2305. Available: http://legacy.library.ucsf.edu/tid/bgs78e00 [accessed 14 September 2004].
11. Bero L. 2003. Implications of the tobacco industry documents for public health policy. Annu Rev Public Health 24:267-288.
12. Bero L. 2005a. Managing financial conflicts of interest in research. J Am Coll Dent 72:4-9.
13. Bero L. 2005b. Tobacco industry manipulation of research. Public Health Rep 120:200-208.
14. Bero L, Barnes D, Hanauer P, Slade J, Glantz S. 1995. Lawyer control of the tobacco industry's external research program. The Brown and Williamson documents. JAMA 274:241-247.
15. Bero L, Galbraith A, Rennie D. 1994. Sponsored symposia on environmental tobacco smoke. JAMA 271:612-617.
16. Bero L, Glantz S, Hong M-K. 2005. The limits of competing interest disclosures. Tob Control 14:118-126.
17. Bero L, Montini T, Bryan-Jones K, Mangurian C. 2001. Science in regulatory policy making: Case studies in the development of workplace smoking restrictions. Tob Control 10:329-336.
18. Bero L, Rennie D. 1996. Influences on the quality of published drug studies. Int J Technol Assess Health Care 12:209-237.
19. Bhandari M, Busse J, Jackowski D, Montori V, Schunemann H, Sprague S, et al. 2004. Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. Can Med Assoc J 170:477-480.
20. Bialous S, Glantz S. 2002. ASHRAE Standard 62: Tobacco industry's influence over national ventilation standards. Tob Control 11:315-328.
21. Bitton A, Neuman M, Barnoya J, Glantz S. 2005. The p53 tumour suppressor gene and the tobacco industry: Research, debate, and conflict of interest. Lancet 365:531-540.
22. Boyd E, Bero L. 2000. Assessing faculty financial relationships with industry. JAMA 284:2209-2214.
23. Boyd E, Cho M, Bero L. 2003 Financial conflict-of-interest policies in clinical research: Issues for clinical investigators. Acad Med 78:769-774.
24. Broin v. Philip Morris Companies, Inc., et al. 1991. Case No. 91-49738, Circuit Court, 11th Judicial Circuit, Dade County, Florida.
25. Broin v. Philip Morris Companies, Inc., et al. 1997. Case No. 91-49738, Circuit Court, 11th Judicial Circuit, Dade County, Florida. Available: http://legacy.library.ucsf.edu/tid/emz75a00 [accessed 5 February 2005].
26. Bryan-Jones K, Bero L. 2003. Tobacco industry efforts to defeat the Occupational Safety and Health Administration indoor air quality rule. Am J Public Health 93:585-592.
27. Cho M, Bero L. 1996. The quality of drug studies published in symposium proceedings. Ann Intern Med 124:485-489.
28. CIAR (Center for Indoor Air Research). 1992. CIAR. Proposed CIAR Applied Projects. Bates No. 20225473891, Available: http://legacy.library.ucsf.edu/tid/dqx42d00 [accessed 2 October 2004].
29. CIAR (Center for Indoor Air Research). 1993. CIAR Applied Project ETS Exposure Assessment Study. Bates No. 2024211848. Available: http://legacy.library.ucsf.edu/tid/epl24e00 [accessed 2 October 2004].
30. CIAR (Center for Indoor Air Research). 1994. CIAR Accomplishments 1993-94. Bates No. 517578887/8888. Available: http://legacy.library.ucsf.edu/tid/nkh31d00 [accessed 2 October 2004].
31. Colucci A. 1984. Study Plan for Environmental Tobacco Smoke. 19841116. Bates No. 504904889/4893. Available: http://legacy.library.ucsf.edu/tid/ dni66d00 [accessed 2 October 2004].
32. Colucci A. 1985. ETS/Research. 19850606. Bates No. 504932368/2370. Available: http://legacy.library.ucsf.edu/tid/emu35d00 [accessed 2 October 2004].
33. Daubert v. Merrell Dow Pharmaceuticals, Inc. 1993. Case No. 92-102, U.S. Supreme Court.
34. Davis R, Stiles M. 1992. The Determination of Cotinine Concentration in Saliva Samples: ETS Nine Cities Study. 19920505. Bates No. 508204250/ 4251. Available: http://legacy.library.ucsf.edu/tid/qpg04d00 [accessed 1 November 2004].
35. Drope J, Bialous S, Glantz S. 2004. Tobacco industry efforts to present ventilation as an altermative to smoke-free environments in North America. Tob Control 13:141-147.
36. Drope J, Chapman S. 2001. Tobacco industry efforts at discrediting scientific knowledge of environmental tobacco smoke: A review of internal industry documents. J Epidemiol Community Health 55:588-594.
37. Eisenberg M. 1993. Center for Indoor Air Research. Fax Cover Sheet to D. Heck. 19930218. Bates No. 87603676. Available: http://legacy.library.ucsf.edu/tid/fql11e00 [accessed 1 November 2004].
38. Eisenberg M. 1994. Meeting with ORNL re Exposure Study. 19940202. Bates No. 89240135. Available: http://legacy.library.ucsf.edu/tid/sgj01e00 [accessed 1 November 2004].
39. General Electric Co. v. Joiner. 1997. Case No. 96-188, U.S. Supreme Court.
40. Glantz S, Slade J, Bero L, Hanauer P, Barnes D, eds. 1996. The Cigarette Papers. Berkeley:UNiversity of California Press.
41. Glaser B, Bero L. 2005. Attitudes of academic and clinical researchers toward financial ties in research: A systematic review. Sci Eng Ethics 11:553-573.
42. Graves C, Ginevan M, Jenkins R, Tardiff R. 2000. Doses and lung burdens of environmental tobacco smoke constituents in nonsmoking workplaces. J Expo Anal Environ Epidemiol 10:365-377.
43. Green C. 1992. Smoke Chemistry and Physics Monthly Highlights. 19921210. Bates No. 518890338/0341. Available: http://legacy.library.ucsf.edu/tid/ ngj97c00 [accessed 3 October 2004].
44. Green C. 1995a. Nationwide Indoor Air Quality Study. 19950207. Bates No. 524131232. Available: http://legacy.library.ucsf.edu/tid/nzb51c00 [accessed 3 October 2004].
45. Green C. 1995b. ORNL Study: Next Steps. 19950413. Bates No. 89273021. Available: http://legacy.library.ucsf.edu/tid/hiu20e00 [accessed 3 October 2004].
46. Green C. 1997a. Funding by the Center for Indoor Air Research. J Health Polit Policy Law 22:1279-1293.
47. Green C. 1997b. Letter to Dr. Lippiello re Promotion of Dr. Ogden. 19970710. Bates No. 519274420/4426. [Document unavailable online due to claim of confidentiality by RJR.] U.S. Exhibit No. 30351, Dept of Justice v. Philip Morris USA et al. 1999. Docket No. CA99-02496, U.S. District Court for the District of Columbia, Washington, DC.
48. Guerin M, Jenkins R, Tomkins B. 1992. The Chemistry of Environmental Tobacco Smoke: Composition and MeasuEement. Chelsea, MI:Lewis Publishers.
49. Hammond S, Sorenson G, Youngstrom R, Ockene J. 1995. Occupational exposure to environmental tobacco smoke. JAMA 274:956-960.
50. Heck D. 1993. CIAR Board of Directors Conference Call. 19930219. Bates No. 87603666/3670. Available: http://legacy.library.ucsf.edu/tid/ cql11e00 [accessed 15 November 2004].
51. Heck D. 1994. CIAR Board of Directors Call. 19940117. Bates No. 89240130/ 0131. Available: http://legacy.library.ucsf.edu/tid/pgj01e00 [accessed 15 November 2004].
52. Hirayama T. 1981. Non-smoking wives of heavy smokers have a higher risk of lung cancer: A study from Japan. BMJ (Clin Res Ed) 282:183-185.
53. Hirschhorn N, Bialous S. 2001. Secondhand smoke and risk assessment: what was in it for the tobacco industry? Tob Control 10:375-382.
54. Hong M-K, Bero L. 2002. How the tobacco industry responded to an influential study of the health effects of secondhand smoke. BMJ 325:1413-1416.
55. Jenkins R. 1993. Letter to M. Eisenberg CIAR Executive Director. 19931228. Bates No. 89240175/0180. Available: http://legacy.library.ucsf.edu/tid/bhj01e00 [accessed 5 November 2004].
56. Jenkins R. 1994a. Addendum to Comments on Proposed Rulemaking. 19941222. Bates No. 89274081/4102. Available: http://legacy.library.ucsf.edu/tid/ yyt20e00 [accessed 7 November 2004].
57. Jenkins R. 1994b. Comments on Proposed Rulemaking, Indoor Air Quality. 19940812. Bates No. 970341653/1662. Available: http://legacy.library.ucsf.edu/tid/wxv90c00 [accessed 5 November 2004].
58. Jenkins R. 1994c. Determination of Human Exposure to Environmental Tobacco Smoke - Project Status and Summary. 19940316. Bates No. 89274725/ 4759. Available: http://legacy.library.ucsf.edu/tid/qii01e00 [accessed 5 November 2004].
59. Jenkins R. 1994d. Determination of Human Exposure to Environmental Tobacco Smoke Project Status and Summary. 19940316. Bates No. 89274725/ 4759. Available: http://legacy.library.ucsf.edu/tid/qii01e00 [accessed 5 November 2004].
60. Jenkins R. 1994e. Memo to Max Eisenberg, CIAR, Re Augmenting 12-Cities Study. 01041994. Bates No. 89240181. Available: http://legacy.library.ucsf.edu/tid/chj01e00 [accessed 5 November 2004].
61. Jenkins R. 1995a. Post Hearing Comments: Proposed Rulemaking Indoor Air Quality. 19950829. Bates No. 89273833/3866. Available: http://legacy.library.ucsf.edu/tid/byt20e00 [accessed 5 November 2004].
62. Jenkins R. 1995b. Summary of Recommendations - CIAR Advisory Committee 19950525. Bates No. 89273030/3031. Available: http://legacy.library.ucsf.edu/tid/jvm23c00 [accessed 15 November 2004].
63. Jenkins R, Counts R. 1999. Occupational exposure to environmental tobacco smoke: Results of two personal exposure studies. Environ Health Perspect 107:341-348.
64. Jenkins R, Guerin M. 1993. Statement of Work to the Center for Indoor Air Research; Determination of Human Exposure to Environmental Tobacco Smoke 19930216. Bates No. 87803051/3054. Available: http://legacy.library.ucsf.edu/tid/hll21e00 [accessed 5 November 2004].
65. Jenkins R, Guerin M. 1994. Interim Report No. 3 Determination of Human Exposure to Environmental Tobacco Smoke Initial Summary of Data from Cities 1-12. 19940810. Bates No. 89817879/7899. Available: http://legacy.library.ucsf.edu/tid/ewb01e00 [accessed 5 November 2004].
66. Jenkins R, Guerin M. 1995a. Determination of Personal Exposure of Non-Smokers to Environmental Tobacco Smoke - Presentation to OSHA. 19950105. Bates No. 2057836274/6321. Available: http://legacy.library.ucsf.edu/tid/qxl42d00 [accessed 15 November 2004].
67. Jenkins R, Guerin M. 1995b. Determination of Personal Exposure of Non-Smokers to Environmental Tobacco Smoke - Project Update and Comments on Proposed Rulemaking. 19950105 Bates No. 2057836274/6321. Available: http://legacy.library.ucsf.edu/tid/qxl42d00 [accessed 15 November 2004].
68. Jenkins R, Palausky A, Counts R, Bayne C, Dindal A, Guerin M. 1996. Exposure to environmental tobacco smoke in sixteen cities in the United States as determined by personal breathing zone air sampling. J Expo Anal Environ Epidemiol 6:473-502.
69. LaKind J, Graves C, Ginevan M, Jenkins R, Naiman D, Tardiff R. 1999. Exposure to environmental tobacco smoke in the workplace and the impact of away-from-work exposure. Risk Anal 19:349-358.
70. Lancet. 2006. Information for Authors. Available: http://www.thelancet.com/authors/lancet/authorinfo [accessed 2 March 2006].
71. Lee P. 1995. "Marriage to a smoker" may not be a valid marker of exposure in studies relating environmental tobacco smoke to risk of lung cancer in Japanese non-smoking women. Int Arch Occup Environ Health 67:287-294.
72. Levine J, Gussow J, Hastings D, Eccher A. 2003. Authors' financial relationships with the food and beverage industry and their published positions on the fat substitute Olestra. Am J Public Health 93:664-669.
73. Lexchin J, Bero L, Djulbegovic B, Clark O. 2003. Pharmaceutical industry sponsorship and research outcome and quality: Systematic review. BMJ 326:1167-1170.
74. Lipton S, Boyd E, Bero L. 2004. Conflicts of interest in academic research: Policies, processes and attitudes. Accountability Res 11:83-102.
75. Maiolo K. 1993. Report of Trip to Knoxville, TN, 1st City in the 1993 Air Quality Study. 19930525. Bates No. 515209267. Available: http://legacy.library.ucsf.edu/tid/fsc03d00 [accessed 15 December 2004].
76. Maiolo K. 1994. Report of Trip to New Orleans, LA, 16th City of 16 in the 1993-94 Air Quality Study. Bates No. 515209275/9276. Available: http://legacy.library.ucsf.edu/tid/isc03d00 [accessed 15 December 2004].
77. Malmfors T, Thorburn D, Westlin A. 1989. Air quality in passenger cabins of DC-9 and MD-80 aircraft. Environ Technol Lett 10:613-628.
78. Malone R, Bero L. 2003. Chasing the dollar: Why scientists should decline tobacco industry funding. J Epidemiol Community Health 57:546-548.
79. Martinson B, Anderson M, de Vries R. 2005. Scientists behaving badly. Nature 435:737-738.
80. McKee M. 2003. Competing interests: The importance of transparency. Eur J Public Health 13:193-194.
81. Meridian Research. 1988. Review of Four Studies Estimating the Risk of Exposure to Environmental Tobacco Smoke, Final Report. 19880324. Bates No. 980147433/7472. Available: http://legacy.library.ucsf.edu/tid/ noz84100 [accessed 5 January 2005].
82. Muggli ME, Forster J, Hurt RD, Repace J. 2001. The smoke you don't see: uncovering tobacco industry scientific strategies aimed against environmental tobacco smoke policies. Am J Public Health 91:1419-1423.
83. Muggli ME, Hurt RD, Blanke DD. 2003. Science for hire: A tobacco industry strategy to influence public opinion on secondhand smoke. Nicotine Tob Res 5:303-314.
84. Muggli ME, Hurt RD, Repace J. 2004. The tobacco industry's political efforts to derail the EPA report on ETS. Am J Prev Med 26:167-176.
85. Neilsen K, Glantz S. 2003. A tobacco industry study of airline cabin air quality: Dropping inconvenient findings. Tob Control 13:i20-i29.
86. NIOSH (National Institute for Occupational Safety and Health). 1991. Environmental Tobacco Smoke in the Workplace: Lung Cancer and Other Health Effects. Available: http://www.cdc.gov/niosh/91108_54.html [accessed 5 November 2004].
87. NRC (National Research Council). 1986a. The Airliner Cabin: Air Quality and Safety. Washington, DC:National Academies Press.
88. NRC (National Research Council). 1986b. Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. Washington, DC:National Academies Press.
89. Ogden M. 1993. Environmental Tobacco Smoke Exposure Study Meeting 930128. 19930128. Bates No. 2023698933. Available: http://legacy.library.ucsf.edu/tid/qzi78e00 [accessed 15 December 2004].
90. Ogden M. 1995. 16-City Study of personal exposure to environmental tobacco smoke: City 5 (Boise, ID). 19951108. Bates No. 520030795/0797. Available: http://legacy.library.ucsf.edu/tid/bgp61d00 [accessed 15 December 2004].
91. Ogden M. 1997. Accomplishments since promotion to Master Scientist. 19970630. Bates No. 522057702/7708. [Document unavailable online due to claim of confidentiality by RJR.] U.S. Exhibit No. 93165, Dept of Justice v. Philip Morris USA et al. 1999. Docket No. CA99-02496, U.S. District Court for the District of Columbia, Washington, DC.
92. Ogden M, Morgan W, Heavner D, Davis R, Steichen T. 1997. National incidence of smoking and misclassification among the U.S. married female population. J Clin Epidemiol 50:253-263.
93. Ong E, Glantz S. 2001. Constructing "sound science" and "good epidemiology": Tobacco, lawyers, and public relations firms. Am J Public Health 91:1749-1757.
94. OSHA (Occupational Safety and Health Administration). 1991. Occupational Exposure to Indoor Air Pollutants; Request for Information. Fed Reg 56:47892-47897.
95. OSHA (Occupational Safety and Health Administration). 1994. Indoor Air Quality; Proposed Rule. Fed Reg 59:15968-16039.
96. OSHA (Occupational Safety and Health Administration). 1995. Transcript of Public Hearing on Proposed Standard for Indoor Air Quality, Docket No. H-122.
97. Public Citizen. 1987. Petition Requesting an Emergency Temporary Standard to Prohibit Smoking in Indoor Workplaces. 19870506. Bates No. 2025816015/6029. Available: http://legacy.library.ucsf.edu/tid/eso85e00 [accessed 5 December 2004].
98. Sapphire Group. 1997. Technical Review of a Distributional Analysis of External and Systemic Doses of ETS Chemicals Based on the 16-Cites Data. Bates No. 2060580075/0138. Available: http://legacy.library.ucsf.edu/tid/ tpy87e00 [accessed 5 February 2005].
99. Schotland M, Bero L. 2002. Evaluating public commentary and scientific evidence submitted in the development of a risk assessment. Risk Anal 22:131-140.
100. Shamasunder B, Bero L. 2002. Financial ties and conflicts of interest between pharmaceutical and tobacco companies. JAMA 288:738-744.
101. Tardiff R. 1996. Proposal Letter to CIAR re use of 16-Cities Data for Additional Analyses. 19961004. Bates No. 566946701/6705. Available: http://legacy.library.ucsf.edu/tid/kfx91d00 [accessed 10 February 2005].
102. Tardiff R. 1997. Sapphire Group. Detailed Characterization of the Distributions of Exposures Among Various Human Groups to Selected Chemicals in Indoor Air Status Report: Phase 2. 19970630. Bates No. 2063643685/3717. Available: http://legacy.library.ucsf.edu/tid/gvh67e00 [accessed 10 February 2005].
103. Tardiff R. 1998. Sapphire Group. Detailed Characterization of the Distributions of Exposures Among Various Human Groups to Selected Chemicals in Indoor Air. 19980300E. Bates No. 2063813780/3783. Available: http://legacy.library.ucsf.edu/tid/mkr45d00 [accessed 10 February 2005].
104. TI (Tobacco Institute). 1991a. EPA Projects, OSHA Projects. Bates No. 87717939/7947. Available: http://legacy.library.ucsf.edu/tid/mgj21e00 [accessed 9 September 2004].
105. TI (Tobacco Institute). 1991b. EPA/OSHA Strategic Plan. Bates No. 87765600/5608. Available: http://legacy.library.ucsf.edu/tid/gvp21e00 [accessed 9 September 2004].
106. TI (Tobacco Institute). 1991c. Executive Committee Meeting Minutes, April 11, 1991. 19910411. Bates No. TIMN0019133/9138. Available: http://legacy.library.ucsf.edu/tid/afm03f00 [accessed 9 September 2004].
107. TI (Tobacco Institute). 1991d. Minutes of Meeting of the Executive Committee 19910808, Washington, D.C. 19910808. Bates No. TI11120824/ 0829. Available: http://legacy.library.ucsf.edu/tid/gxl17d00 [accessed 9 September 2004].
108. Tong E, England L, Glantz S. 2005. Changing conclusions on secondhand smoke in a sudden infant death syndrome review funded by the tobacco industry. Pediatrics 115:e356-e366.
109. Turner S, Cyr L, Gross A. 1992. The measurement of environmental tobacco smoke in 585 office environments. Environ Int 18:10-28.
110. U.S. DHHS. 1986. The Health Consequences of Involuntary Smoking: A Report of the Surgeon General. Washington, DC:U.S. Government Printing Office.
111. U.S. EPA. 1992. Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders. EPA/600/6-90/006F. Office of Research and Development, U.S. EPA, Washington, DC.
112. Wheeler J. 1988. Research and Development, External Influences. 19880707. Bates No. 506552033/2036. Available: http://legacy.library.ucsf.edu/tid/mwx54d00 [accessed 2 October 2004].
113. Wilson C. 1997. Tobacco defense: Judge's remark warrants mistrial. The Miami Herald (Miami, FL), 24 September: 2B.
114. Yano E. 2005. Japanese spousal smoking study: How a tobacco industry funded paper reached erroneous conclusions. Tob Control 14:227-233.
115. Yaphe J, Edman R, Knishkowy B, Herman J. 2001. The association between funding by commercial interests and study outcome in randomized controlled drug trials. Fam Pract 18:565-568.