The Hansenula polymorpha PDD1 gene product, essential for the selective degradation of peroxisomes, is a homologue of Saccharomyces cerevisiae Vps34p

Yeast

Volumn 15, Issue 9, 1999, Pages 741-754

  Kiel, J A K W ^a   Rechinger, K B ^b,c   Van Der Klei, I J ^a   Salomons, F A ^a   Titorenko, V I ^a,d   Veenhuis, M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b CARLSBERG LABORATORY   (Denmark)

^c Department of Dairy and Food Science   (Denmark)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Autophagosome; Catabolite inactivation; Methylotrophic yeast; Microbody; Phosphatidylinositol 3 kinase

Indexed keywords

GENE PRODUCT;

ARTICLE; FUNGAL GENETICS; FUNGUS MUTANT; GENE EXPRESSION; GENETIC COMPLEMENTATION; HANSENULA POLYMORPHA; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; CELL FRACTIONATION; CELL MEMBRANE; CLONING, MOLECULAR; FUNGAL PROTEINS; GENE DELETION; GENETIC COMPLEMENTATION TEST; MEMBRANE PROTEINS; MICROBODIES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; OPEN READING FRAMES; PICHIA; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; VACUOLES;

FUNGI; PICHIA ANGUSTA; SACCHAROMYCES CEREVISIAE;

EID: 0033618147     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(19990630)15:9<741::AID-YEA416>3.0.CO;2-O     Document Type: Article

References (38)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Baerends, R. J. S., Salomons, F. A., Kiel, J. A. K. W., Van der Klei, I. J. and Veenhuis, M. (1997). Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: a sudden increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes. Yeast 13, 1449-1463.
3. Bellu, A. R., Van der Klei, I. J., Rechinger, K. B., Yavuz, M., Veenhuis, M. and Kiel, J. A. K. W. (1999). Characterization of the Hansenula polymorpha CPY gene encoding carboxypeptidase Y. Yeast 15, 181-185.
4. Chiang, H-L., Schekman, R. and Hamamoto, S. (1996). Selective uptake of cytosolic, peroxisomal, and plasma membrane proteins into the yeast lysosome for degradation. J. Biol. Chem. 271, 9934-9941.
5. De Camilli, P., Emr, S. D., McPherson, P. S. and Novick, P. (1996). Phosphoinositides as regulators in membrane traffic. Science 271, 1533-1539.
6. DeWald, D. B., Wurmser, A. E. and Emr, S. D. (1997). Regulation of the Saccharomyces cerevisiae Vps34p phosphatidylinositol 3-kinase. Biochem. Soc. Trans. 25, 1141-1146.
7. Douma, A. C., Veenhuis, M., De Koning, W., Evers, M. E. and Harder, W. (1985). Dihydroxyacetone synthase is localized in the peroxisomal matrix of methanol-grown Hansenula polymorpha. Arch. Microbiol. 143, 237-243.
8. Dunn, W. A. (1990). Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J. Cell Biol. 110, 1923-1933.
9. Eck, R., Beer, K. and Wetzker, R. (1996). GenBank Accession No. Y09043.
10. Faber, K. N., Van der Klei, I. J., Keizer-Gunnink, I., Gietl, C., Harder, W. and Veenhuis, M. (1993). Watermelon glyoxysomal malate dehydrogenase is sorted to peroxisomes of the methylotrophic yeast Hansenula polymorpha. FEBS Lett. 334, 128-132.
11. Faber, K. N., Haima, P., Harder, W., Veenhuis, M. and AB, G. (1994). Highly efficient electrotransformation of the yeast Hansenula polymorpha. Curr. Genet. 25, 305-310.
12. Gleeson, M. A. and Sudbery, P. E. (1988). Genetic analysis in the methylotrophic yeast Hansenula polymorpha. Yeast 4, 293-303.
13. Herman, P. K. and Emr, S. D. (1990). Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell Biol. 10, 6742-6754.
14. Jones, E. W. (1991). Tackling the protease problem in Saccharomyces cerevisiae. Methods Enzymol. 194, 429-453.
15. Keizer-Gunnink, I., Roggenkamp, R., Harder, W. and Veenhuis, M. (1992). Location of catalase in crystalline peroxisomes of methanol-grown Hansenula polymorpha. FEMS Microbiol. Lett. 93, 7-12.
16. Kiel, J. A. K. W., Keizer-Gunnink, I., Krause, T., Komori, M. and Veenhuis, M. (1995). Heterologous complementation of peroxisome function in yeast: the Saccharomyces cerevisiae PAS3 gene restores peroxisome biogenesis in a Hansenula polymorpha per9 disruption mutant. FEBS Lett. 377, 434-438.
17. Lazarow, P. B. and Fujiki, Y. (1985). Biogenesis of peroxisomes. Ann. Rev. Cell Biol. 1, 489-530.
18. Mayer, B. J. and Eck, M. J. (1995). Minding your ps and qs. Curr. Biol. 5, 364-367.
19. Merckelbach, A., Gödecke, S., Janowicz, Z. A. and Hollenberg, C. P. (1993). Cloning and sequencing of the URA3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement. Appl. Microbiol. Biotechnol. 40, 361-364.
20. +-ATPase-defenctive yeast: identification of six new END genes. J. Cell Biol. 127, 373-386.
21. Panaretou, C., Domin, J., Cockcroft, S. and Waterfield, M. D. (1997). Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. J. Biol. Chem. 272, 2477-2485.
22. Sakai, Y., Koller, A., Rangell, L. K., Keller, G. A. and Subramani, S. (1998). Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates. J. Cell Biol. 141, 625-636.
23. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York.
24. Stack, J. H., Horazdovsky, B. and Emr, S. D. (1995). Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Ann. Rev. Cell Dev. Biol. 11, 1-33.
25. Tan, X., Waterham, H. R., Veenhuis, M. and Cregg, J. M. (1995). The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. J. Cell Biol. 128, 307-319.
26. Titorenko, V. I., Keizer, I., Harder, W. and Veenhuis, M. (1995). Isolation and characterization of mutants impaired in the selective degradation of peroxisomes in the yeast Hansenula polymorpha. J. Bacteriol. 177, 357-363.
27. Tuttle, D. L. and Dunn, W. A. Jr (1995). Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris. J. Cell Sci. 108, 25-35.
28. Ueno, T., Muno, D. and Kominami, E. (1991). Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver. J. Biol. Chem. 266, 18995-18999.
29. Van der Klei, I. J., Harder, W. and Veenhuis, M. (1991). Selective inactivation of alcohol oxidase in two peroxisome-defecient mutants of the yeast Hansenula polymorpha. Yeast 7, 813-821.
30. Van der Klei, I. J., Van der Heide, M., Baerends, R. J. S., Rechinger, K. B., Nicolay, K., Kiel, J. A. K. W. and Veenhuis, M. (1998). The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel peroxisome-associated protein, Pak1p. Curr. Genet. 34, 1-11.
31. Van Dijken, J. P., Otto, R. and Harder, W. (1976). Growth of Hansenula polymorpha in a methanol-limited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism. Arch. Microbiol. 111, 137-144.
32. Veenhuis, M., Douma, A., Harder, W. and Osumi, M. (1983). Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes. Arch. Microbiol. 134, 193-203.
33. Veenhuis, M. and Harder, W. (1991). Microbodies. In Rose, A. (ed.), The Yeasts, Vol. 4. Academic Press, New York, pp. 601-653.
34. Veenhuis, M., Komori, M., Salomons, F., Hilbrands, R. E., Hut, H., Baerends, R. J. S., Kiel, J. A. K. W. and Van der Klei, I. J. (1996). Peroxisomal remnants in peroxisome-deficient mutants of the yeast Hansenula polymorpha. FEBS Lett. 383, 114-118.
35. Volinia, S., Dhand, R., Vanhaesebroeck, B., MacDougall, L. K., Stein, R., Zvelebil, M. J., Domin, J., Panaretou, C. and Waterfield, M. D. (1995). A human phosphatidylinosityl 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14, 3339-3348.
36. Waterham, H. R., Titorenko, V. I., Haima, P., Cregg, J. M., Harder, W. and Veenhuis, M. (1994). The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals. J. Cell Biol. 137, 737-749.
37. Yanish-Perron, C., Vieira, J. and Messing, J. (1985). Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33, 103-119.
38. Yuan, W., Tuttle, D. L., Shi, Y-J., Ralph, G. S. and Dunn, W. A. Jr (1997). Glucose-induced microautophagy in Pichia pastoris requires the α-subunit of phosphofructokinase. J. Cell Sci. 110, 1935-1945.