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Volumn 37, Issue 3, 2002, Pages 207-217
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Reactions of purines-containing butenolides with L-cysteine or N-acetyl-L-cysteine as model biological nucleophiles: A potent mechanism-based inhibitor of ribonucleotide reductase caused apoptosis in breast carcinoma MCF7 cells
a
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Author keywords
Adenine; Antitumoral activity; Apoptosis; Biological nucleophiles; Butenolides; L cysteine; Ribonucleotide reductase
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Indexed keywords
ACETYLCYSTEINE;
ACETYLCYSTEINE DERIVATIVE;
ACID ANHYDRIDE;
ADENINE DERIVATIVE;
ANTINEOPLASTIC AGENT;
BUTENOLIDE DERIVATIVE;
CYSTEINE;
DITHIOTHREITOL;
ENZYME INHIBITOR;
GLUTATHIONE;
PHOSPHOROTHIOIC ACID DERIVATIVE;
PURINE DERIVATIVE;
RIBONUCLEOTIDE REDUCTASE;
UNCLASSIFIED DRUG;
ANTINEOPLASTIC ACTIVITY;
APOPTOSIS;
ARTICLE;
BREAST CARCINOMA;
CANCER CELL CULTURE;
CARCINOMA CELL;
CELL NUCLEUS;
CELL SIZE;
CHEMICAL REACTION KINETICS;
CONTROLLED STUDY;
CORRELATION ANALYSIS;
COVALENT BOND;
CYTOTOXICITY;
DRUG ACTIVITY;
DRUG POTENCY;
ENZYME INHIBITION;
ESCHERICHIA COLI;
HUMAN;
HUMAN CELL;
MOLECULAR MODEL;
NONHUMAN;
PRECURSOR;
STRUCTURE ACTIVITY RELATION;
4-BUTYROLACTONE;
ACETYLCYSTEINE;
ANIMALS;
ANTINEOPLASTIC AGENTS;
APOPTOSIS;
CELL DIVISION;
CELL LINE;
CYSTEINE;
CYTARABINE;
DOSE-RESPONSE RELATIONSHIP, DRUG;
ESCHERICHIA COLI;
FIBROBLASTS;
FURANS;
HUMANS;
MICE;
MOLECULAR STRUCTURE;
PURINES;
RIBONUCLEOTIDE REDUCTASES;
SULFHYDRYL COMPOUNDS;
TUMOR CELLS, CULTURED;
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EID: 0036501652
PISSN: 02235234
EISSN: None
Source Type: Journal
DOI: 10.1016/S0223-5234(02)01333-8 Document Type: Article |
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Times cited : (17)
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References (37)
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