Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 678-685

  Ivy Carroll, F ^a   Ma, Wei ^a   Navarro, Hernán A ^a   Abraham, Philip ^a   Wolckenhauer, Scott A ^a   Damaj, M I ^b   Martin, Billy R ^b  

^a RTI INTERNATIONAL   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

7 nAChR; Antagonist; Methyllycaconitine; MLA analogs

Indexed keywords

METHYLLYCACONITINE; NICOTINIC RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; MOUSE; NEUROPROTECTION; NONHUMAN; PAIN; RECEPTOR BINDING; SEIZURE;

ACONITINE; ANALGESICS; ANIMALS; ANTICONVULSANTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; BRAIN; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; INDICATORS AND REAGENTS; MALE; MICE; MICE, INBRED ICR; NICOTINE; NICOTINIC AGONISTS; PAIN MEASUREMENT; PYRIDINES; RATS; REACTION TIME; RECEPTORS, NICOTINIC; SEIZURES;

EID: 33845293455     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.061     Document Type: Article

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