Molecular characteristics and in vitro susceptibility to antimicrobial agents, including the des-fluoro(6) quinolone DX-619, of Panton-Valentine leucocidin-positive methicillin-resistant Staphylococcus aureus isolates from the community and hospitals

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 12, 2006, Pages 4077-4086

  Yamamoto, Tatsuo ^a   Dohmae, Soshi ^a   Saito, Kohei ^a   Otsuka, Taketo ^a   Takano, Tomomi ^a   Chiba, Megumi ^b   Fujikawa, Katsuko ^b   Tanaka, Mayumi ^b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; AMPICILLIN; ANTIINFECTIVE AGENT; BETA LACTAM; CEFACLOR; CEFAZOLIN; CEFOTIAM; CEFTAZIDIME; CEPHEM DERIVATIVE; CHLORAMPHENICOL; CLINDAMYCIN; DESFLUORO(6) QUINOLONE; DX 619; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; KANAMYCIN; LINCOSAMIDE; MACROLIDE; MINOCYCLINE; OXACILLIN; PENICILLIN DERIVATIVE; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE; RIFAMPICIN; SITAFLOXACIN; STREPTOMYCIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; UNINDEXED DRUG;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; COMMUNITY; CONTROLLED STUDY; EPIDEMIC; GENETIC TRAIT; GENOTYPE; HOSPITAL; HOSPITAL INFECTION; HUMAN; IN VITRO STUDY; JAPAN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR BIOLOGY; MULTIDRUG RESISTANCE; NONHUMAN; PANTON VALENTINE LEUCOCIDIN GENE; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIAL TOXINS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; EXOTOXINS; FLUOROQUINOLONES; HOSPITALS; HUMANS; LEUKOCIDINS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; PYRROLIDINES; QUINOLONES; RIFAMPIN; STAPHYLOCOCCUS AUREUS;

EID: 33845240353     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00847-06     Document Type: Article

References (57)

1. Akasaka, T., S. Kurosaka, Y. Uchida, M. Tanaka, K. Sato, and I. Hayakawa. 1998. Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases. Antimicrob. Agents Chemother. 42:1284-1287.
2. Andersen, B. M., K. Bergh, M. Steinbakk, G. Syversen, B. Magnaes, H. Dalen, and J. N. Bruun. 1999. A Norwegian nosocomial outbreak of methicillin-resistant Staphylococcus aureus resistant to fusidic acid and susceptible to other antistaphylococcal agents. J. Hosp. Infect. 41:123-132.
3. Becker, K., R. Roth, and G. Peters. 1998. Rapid and specific detection of toxigenic Staphylococcus aureus: use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene. J. Clin. Microbiol. 36:2548-2553.
4. T or SCCmec type IV. J. Clin. Microbiol. 43:4719-4730.
5. Brumfitt, W., and J. Hamilton-Miller. 1989. Methicillin-resistant Staphylococcus aureus. N. Engl. J. Med. 320:1188-1196.
6. Centers for Disease Control and Prevention. 1999. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997-1999. Morb. Mortal. Wkly. Rep. 48:707-710.
7. Choi, S. M., S. H. Kim, H. J. Kim, D. G. Lee, J. H. Choi, J. H. Yoo, J. H. Kang, W. S. Shin, and M. W. Kang. 2003. Multiplex PCR for the detection of genes encoding aminoglycoside modifying enzymes and methicillin resistance among Staphylococcus species. J. Korean Med. Sci. 18:631-636.
8. Clark, N. C., O. Olsvik, J. M. Swenson, C. A. Spiegel, and F. C. Tenover. 1999. Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis. Antimicrob. Agents Chemother. 43:157-160.
9. Clinical and Laboratory Standards Institute. 2005. Performance standard for antimicrobial susceptibility testing; 15th informational supplement. M100-S15. Clinical and Laboratory Standards Institute, Wayne, Pa.
10. Coombs, G. W., G. R. Nimmo, J. M. Bell, F. Huygens, F. G. O'Brien, M. J. Malkowski, J. C. Pearson, A. J. Stephens, P. M. Giffard, and the Australian Group for Antimicrobial Resistance. 2004. Genetic diversity among community methicillin-resistant Staphylococcus aureus strains causing outpatient infections in Australia. J. Clin. Microbiol. 42:4735-4743.
11. Crum, N. F. 2005. The emergence of severe, community-acquired methicillin-resistant Staphylococcus aureus infections. Scand. J. Infect. Dis. 37:651-656.
12. Diep, B. A., G. F. Sensabaugh, N. S. Somboona, H. A. Carleton, and F. Perdreau-Remington. 2004. Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J. Clin. Microbiol. 42:2080-2084.
13. Enright, M. C., N. P. Day, C. E. Davies, S. J. Peacock, and B. G. Spratt. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. Clin. Microbiol. 38:1008-1015.
14. Feil, E. J., B. C. Li, D. M. Aanensen, W. P. Hanage, and B. G. Spratt. 2004. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J. Bacteriol. 186:1518-1530.
15. Ferry, T., D. Thomas, A. L. Genestier, M. Bes, G. Lina, F. Vandenesch, and J. Etienne. 2005. Comparative prevalence of superantigen genes in Staphylococcus aureus isolates causing sepsis with and without septic shock. Clin. Infect. Dis. 41:771-777.
16. Francis, J. S., M. C. Doherty, U. Lopatin, C. P. Johnston, G. Sinha, T. Ross, M. Cai, N. N. Hansel, T. Perl, J. R. Ticehurst, K. Carroll, D. L. Thomas, E. Nuermberger, and J. G. Bartlett. 2005. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin. Infect. Dis. 40:100-107.
17. Fujikawa, K., M. Chiba, M. Tanaka, and K. Sato. 2005. In vitro antibacterial activity of DX-619, a novel des-fluoro(6) quinolone. Antimicrob. Agents Chemother. 49:3040-3045.
18. Fukayama, M., and T. Inamatsu. 1988. Current situation of methicillin-resistant Staphylococcus aureus infections in elderly patients. Clin. Microbiol. 15:174-177. (In Japanese).
19. Genestier, A. L., M. C. Michallet, G. Prévost, G. Bellot, L. Chalabreysse, S. Peyrol, F. Thivolet, J. Etienne, G. Lina, F. M. Vallette, F. Vandenesch, and L. Genestier. 2005. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J. Clin. Investig. 115:3117-3127.
20. Gillespie, W. J. 1990. Epidemiology in bone and joint infection. Infect. Dis. Clin. N. Am. 4:361-376.
21. Goering, R. V., and M. A. Winters. 1992. Rapid method for epidemiological evaluation of gram-positive cocci by field inversion gel electrophoresis. J. Clin. Microbiol. 30:577-580.
22. Gonzalez, B. E., K. G. Hulten, M. K. Dishop, L. B. Lamberth, W. A. Hammerman, E. O. Mason., Jr., and S. L. Kaplan. 2005. Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. Clin. Infect. Dis. 41:583-590.
23. Holtfreter, S., K. Bauer, D. Thomas, C. Feig, V. Lorenz, K. Roschack, E. Friebe, K. Selleng, S. Lövenich, T. Greve, A. Greinacher, B. Panzig, S. Engelmann, G. Lina, and B. M. Bröker. 2004. egc-encoded superantigens from Staphylococcus aureus are neutralized by human sera much less efficiently than are classical staphylococcal enterotoxins or toxic shock syndrome toxin. Infect. Immun. 72:4061-4071.
24. Ito, T., K. Kuwahara, K. Hisata, K. Okuma, L. Cui, and K. Hiramatsu. 2004. Community-associated methicillin-resistant Staphylococcus aureus: current status and molecular epidemiological perspective. Kansenshogaku Zasshi 78:459-469. (In Japanese.)
25. Jarraud, S., G. Cozon, F. Vandenesch, M. Bes, J. Etienne, and G. Lina. 1999. Involvement of enterotoxins G and I in staphylococcal toxic shock syndrome and staphylococcal scarlet fever. J. Clin. Microbiol. 37:2446-2449.
26. Jarraud, S., C. Mougel, J. Thioulouse, G. Lina, H. Meugnier, F. Forey, X. Nesme, J. Etienne, and F. Vandenesch. 2002. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect. Immun. 70:631-641.
27. Konishi, T. 1994. MRSA enteritis. Nippon Rinsho Suppl. 6:45-48. (In Japanese.)
28. Letertre, C., S. Perelle, F. Dilasser, and P. Fach. 2003. Identification of a new putative enterotoxin SEU encoded by the egc cluster of Staphylococcus aureus. J. Appl. Microbiol. 95:38-43.
29. Martineau, F., F. J. Picard, N. Lansac, C. Ménard, P. H. Roy, M. Ouellette, and M. G. Bergeron. 2000. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob. Agents Chemother. 44:231-238.
30. McDougal, L. K., C. D. Steward, G. E. Killgore, J. M. Chaitram, S. K. McAllister, and F. C. Tenover. 2003. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J. Clin. Microbiol. 41:5113-5120.
31. Miklasevics, E., S. Haeggman, A. Balode, B. Sanchez, A. Martinsons, B. Olsson-Liljequist, and U. Dumpis. 2004. Report on the first PVL-positive community acquired MRSA strain in Latvia. Euro. Surveill. 9:29-30.
32. Mongodin, E., O. Bajolet, J. Cutrona, N. Bonnet, F. Dupuit, E. Puchelle, and S. de Bentzmann. 2002. Fibronectin-binding proteins of Staphylococcus aureus are involved in adherence to human airway epithelium. Infect. Immun. 70:620-630.
33. Naimi, T. S., K. H. LeDell, K. Como-Sabetti, S. M. Borchardt, D. J. Boxrud, J. Etienne, S. K. Johnson, F. Vandenesch, S. Fridkin, C. O'Boyle, R. N. Danila, and R. Lynfield. 2003. Comparison of community- and health careassociated methicillin-resistant Staphylococcus aureus infection. JAMA 290:2976-2984.
34. Nakagawa, S., I. Taneike, D. Mimura, N. Iwakura, T. Nakayama, T. Emura, M. Kitatsuji, A. Fujimoto, and T. Yamamoto. 2005. Gene sequences and specific detection for Panton-Valentine leukocidin. Biochem. Biophys. Res. Commun. 328:995-1002.
35. National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 6th ed. Approved standard M7-A6. National Committee for Clinical Laboratory Standards, Wayne, Pa.
36. Nei, M., and W. H. Li. 1979. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76:5269-5273.
37. O'Brien, F. G., T. T. Lim, F. N. Chong, G. W. Coombs, M. C. Enright, D. A. Robinson, A. Monk, B. Said-Salim, B. N. Kreiswirth, and W. B. Grubb. 2004. Diversity among community isolates of methicillin-resistant Staphylococcus aureus in Australia. J. Clin. Microbiol. 42:3185-3190.
38. Oliveira, D. C., and H. de Lencastre. 2002. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 46:2155-2161.
39. Orwin, P. M., D. Y. Leung, H. L. Donahue, R. P. Novick, and P. M. Schlievert. 2001. Biochemical and biological properties of staphylococcal enterotoxin K. Infect. Immun. 69:360-366.
40. Otsuka, T., K. Saito, S. Dohmae, T. Takano, W. Higuchi, Y. Takizawa, T. Okubo, N. Iwakura, and T. Yamamoto. 2006. Key adhesin gene in community-acquired methicillin-resistant Staphylococcus aureus. Biochem. Biophys. Res. Commun. 346:1234-1244.
41. Ribeiro, A., C. Dias, M. C. Silva-Carvalho, L. Berquó, F. A. Ferreira, R. N. S. Santos, B. T. Ferreira-Carvalho, and A. M. Figueiredo. 2005. First report of infection with community-acquired methicillin-resistant Staphylococcus aureus in South America. J. Clin. Microbiol. 43:1985-1988.
42. Rydén, C., I. Maxe, A. Franzén, Å. Ljungh, D. Heinegård, and K. Rubin. 1987. Selective binding of bone matrix sialoprotein to Staphylococcus aureus in osteomyelitis. Lancet ii:515.
43. Rydén, C., H. S. Tung, V. Nikolaev, Å. Engström, and Å. Oldberg. 1997. Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. Biochem. J. 327:825-829.
44. Saiman, L., M. O'Keefe, P. L. Graham III, F. Wu, B. Said-Salim, B. Kreiswirth, A. LaSala, P. M. Schlievert, and P. Della-Latta. 2003. Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin. Infect. Dis. 37:1313-1319.
45. Shimada, K. 1986. Methicillin-resistant Staphylococcus aureus. Nippon Rinsho 44:2112-2121. (In Japanese.)
46. Shopsin, B., M. Gomez, S. O. Montgomery, D. H. Smith, M. Waddington, D. E. Dodge, D. A. Bost, M. Riehman, S. Naidich, and B. N. Kreiswirth. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J. Clin. Microbiol. 37:3556-3563.
47. Strommenger, B., C. Cuny, G. Werner, and W. Witte. 2004. Obvious lack of association between dynamics of epidemic methicillin-resistant Staphylococcus aureus in central Europe and agr specificity groups. Eur. J. Clin. Microbiol. Infect. Dis. 23:15-19.
48. Takizawa, Y., I. Taneike, S. Nakagawa, T. Oishi, Y. Nitahara, N. Iwakura, K. Ozaki, M. Takano, T. Nakayama, and T. Yamamoto. 2005. A Panton-Valentine leucocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan. J. Clin. Microbiol. 43:3356-3363.
49. Taneike, I., T. Otsuka, S. Dohmae, K. Saito, K. Ozaki, M. Takano, W. Higuchi, T. Takano, and T. Yamamoto. 2006. Molecular nature of methicillin-resistant Staphylococcus aureus derived from explosive nosocomial outbreaks of the 1980s in Japan. FEBS Lett. 580:2323-2334.
50. Tristan, A., L. Ying, M. Bes, J. Etienne, F. Vandenesch, and G. Lina. 2003. Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections. J. Clin. Microbiol. 41:4465-4467.
51. Vancraeynest, D., K. Hermans, and F. Haesebrouck. 2004. Genotypic and phenotypic screening of high and low virulence Staphylococcus aureus isolates from rabbits for biofilm formation and MSCRAMMs. Vet. Microbiol. 103:241-247.
52. Vandenesch, F., T. Naimi, M. C. Enright, G. Lina, G. R. Nimmo, H. Heffernan, N. Liassine, M. Bes, T. Greenland, M. E. Reverdy, and J. Etienne. 2003. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg. Infect. Dis. 9:978-984.
53. Vasudevan, P., M. K. Nair, T. Annamalai, and K. S. Venkitanarayanan. 2003. Phenotypic and genotypic characterization of bovine mastitis isolates of Staphylococcus aureus for biofilm formation. Vet. Microbiol. 92:179-185.
54. Williams, R. J., J. M. Ward, B. Henderson, S. Poole, B. P. O'Hara, M. Wilson, and S. P. Nair. 2000. Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1. Infect. Immun. 68:4407-4415.
55. Yamaguchi, T., K. Nishifuji, M. Sasaki, Y. Fudaba, M. Aepfelbacher, T. Takata, M. Ohara, H. Komatsuzawa, M. Amagai, and M. Sugai. 2002. Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect. Immun. 70:5835-5845.
56. Zetola, N., J. S. Francis, E. L. Nuermberger, and W. R. Bishai. 2005. Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect. Dis. 5:275-286.
57. Zhang, S., J. J. Iandolo, and G. C. Stewart. 1998. The enterotoxin D plasmid of Staphylococcus aureus encodes a second enterotoxin determinant (sej). FEMS Microbiol. Lett. 168:227-233.