Manifold decrease of sialic acid synthase in fetal Down syndrome brain

Amino Acids

Volumn 32, Issue 1, 2007, Pages 141-144

  Gulesserian, T ^a   Engidawork, E ^a,b   Fountoulakis, M ^c   Lubec, G ^a,d  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Down syndrome; Fetal brain; Sialic acid; Sialic acid synthase; Two dimensional gel electrophoresis

Indexed keywords

N ACETYLNEURAMINIC ACID; SIALIC ACID; SIALIC ACID SYNTHASE; SYNTHETASE;

BRAIN CORTEX; BRAIN DEVELOPMENT; CARBOHYDRATE METABOLISM; CATALYSIS; CLINICAL ARTICLE; COMPUTER PROGRAM; CONFERENCE PAPER; CONTROLLED STUDY; DATA BASE; DOWN SYNDROME; FEMALE; FETUS; FETUS CONTROL; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SECOND TRIMESTER PREGNANCY; SIALYLATION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ABORTED FETUS; CEREBRAL CORTEX; DOWN SYNDROME; FEMALE; GLYCOCONJUGATES; HUMANS; MALE; MYELIN-ASSOCIATED GLYCOPROTEIN; NEURONS; OXO-ACID-LYASES; PREGNANCY; PREGNANCY TRIMESTER, SECOND; SIALIC ACIDS;

EID: 33845234812     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-006-0325-y     Document Type: Conference Paper

References (33)

1. P Berndt U Hobohm H Langen 1999 Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints Electrophoresis 20 3521 3526
2. FH Blackhall CL Merry EJ Davies GC Jayson 2001 Heparan sulfate proteoglycans and cancer Br J Cancer 85 1094 1098
3. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
4. I Brockhausen 1999 Pathways of O-glycan biosynthesis in cancer cells Biochim Biophys Acta 1473 67 95
5. BW Brooksbank J [tmp] McGovern 1989 Gangliosides in the brain in adult Down's syndrome and Alzheimer's disease Mol Chem Neuropathol 11 143 156
6. BW Brooksbank D Walker R Balazs OS Jorgensen 1989 Neuronal maturation in the foetal brain in Down's syndrome Early Hum Dev 18 237 246
7. B Buttner C Kannicht C Schmidt K Loster W Reutter HY Lee S Nohring R Horstkorte 2002 Biochemical engineering of cell surface sialic acids stimulates axonal growth J Neurosci 22 8869 8875
8. NW Charter LK Mahal DE Koshland Jr CR Bertozzi 2002 Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior J Biol Chem 277 9255 9261
9. PR Crocker A Varki 2001 Siglecs in the immune system Immunology 103 137 145
10. P Doherty FS Walsh 1996 CAM-FGF receptor interactions: a model for axonal growth Mol Cell Neurosci 8 99 111
11. E Engidawork G Lubec 2001 Protein expression in Down syndrome brain Amino Acids 21 331 361
12. E Engidawork G Lubec 2003 Molecular changes in fetal Down syndrome brain J Neurochem 84 895 904
13. M Fountoulakis 2001 Proteomics: current technologies and applications in neurological disorders and toxicology Amino Acids 21 363 381
14. H Hu H Tomasiewicz T Magnuson U Rutishauser 1996 The role of polysialic acid in migration of olfactory bulb interneuron precursors in the subventricular zone Neuron 16 735 743
15. TS Hwang CH Hung CF Teo GT Chen LS Chang SF Chen YJ Chen CH Lin 2002 Structural characterization of Escherichia coli sialic acid synthase Biochem Biophys Res Commun 295 167 173
16. OS Jorgensen BW Brooksbank R Balazs 1990 Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease J Neurol Sci 98 63 79
17. P Kursula VP Lehto AM Heape 2000 Estimation of total ribonucleic acid quantity from dilute samples by nondenaturing electrophoresis and silver staining Electrophoresis 21 545 547
18. SM Lawrence KA Huddleston LR Pitts N Nguyen YC Lee WF Vann TA Coleman MJ Betenbaugh 2000 Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability J Biol Chem 275 17869 17877
19. G Lubec E Engidawork 2002 The brain in Down syndrome (Trisomy 21) J Neurol 249 1347 1356
20. Y Masuda S Ohnuma T Shimizu Y Hishikawa 1997 High sialic acid reactivity of sugar chain structure Lewis-X in patients with mental retardation Biol Psychiatry 42 68 71
21. H Matsuhashi Y Horii K Kato 2003 Region-specific and epileptogenic- dependent expression of six subtypes of alpha 2,3-sialyltransferase in the adult mouse brain J Neurochem 84 53 66
22. R Minana M Sancho-Tello E Climent JM Segui J Renau-Piqueras C Guerri 1998 Intracellular location, temporal expression, and polysialylation of neural cell adhesion molecule in astrocytes in primary culture Glia 24 415 427
23. JE Oh K Karlmark Raja JH Shin M Hengstschlager A Pollak G Lubec 2005 The neuronal differentiation process involves a series of antioxidant proteins Amino Acids 29 273 282
24. KA Sheikh J Sun Y Liu H Kawai TO Crawford RL Proia JW Griffin RL Schnaar 1999 Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects Proc Natl Acad Sci USA 96 7532 7537
25. JH Shin E Engidawork JM Delabar G Lubec 2005 Identification and characterisation of soluble epoxide hydrolase in mouse brain by a robust protein biochemical method Amino Acids 28 63 69
26. J Sun NL Shaper S Itonori M Heffer-Lauc KA Sheikh RL Schnaar 2004 Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides Glycobiology 14 851 857
27. U Unterberger G Lubec M Dierssen G Stoltenburg-Didinger JC Farreras H Budka 2003 The cerebral cortex in fetal Down syndrome J Neural Transm Suppl 67 159 163
28. M Vinson PJ Strijbos A Rowles L Facci SE Moore DL Simmons FS Walsh 2001 Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition J Biol Chem 276 20280 20285
29. R Vlkolinsky N Cairns M Fountoulakis G Lubec 2001 Decreased brain levels of 2′, 3′-cyclic nucleotide-3′-cyclic phosphodiesterase in Down syndrome and Alzheimer's disease Neurobiol Aging 22 547 553
30. R Weitzdoerfer M Fountoulakis G Lubec 2002 Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain Biochem Biophys Res Commun 293 836 841
31. KE Wisniewski 1990 Down syndrome children often have brain with maturation delay retardation growth, and cortical dysgenesis Am J Med Genet Suppl 7 274 281
32. KE Wisniewski B Schmidt-Sidor 1989 Postnatal delay of myelin formation in brains from Down syndrome infants and children Clin Neuropathol 8 55 62
33. JW Yang T Czech G Lubec 2004 Proteomic profiling of human hippocampus Electrophoresis 25 1169 1174