The cerebral cortex in Fetal Down Syndrome

Journal of Neural Transmission, Supplement

Volumn , Issue 67, 2003, Pages 159-163

  Unterberger, U ^a   Lubec, G ^a   Dierssen, M ^b   Stoltenburg Didinger, G ^c   Farreras, J C ^d   Budka, H ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Hospital Universitari Parc Taulí   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; DREBRIN;

ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CONTROLLED STUDY; DOWN SYNDROME; FETUS; FETUS DEVELOPMENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SYNAPSE;

EID: 1542719732     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6721-2_14     Document Type: Article

References (13)

1. Becker LE, Armstrong DL, Chan F (1986) Dendritic atrophy in children with Down's syndrome. Ann Neurol 20(4): 520-526
2. Ellison D, Love S (1998) Neuropathology. Mosby International, London, pp 3.26-3.37
3. Engidawork E, Lubec G (2003) Molecular changes in fetal Down syndrome brain. J Neurochem 84: 895-904
4. nd rev and expanded edn. Springer, Berlin Heidelberg New York, pp 330-346
5. Golden JA, Hyman BT (1994) Development of the superior temporal neocortex is anomalous in Trisomy 21. J Neuropathol Exp Neurol 53(5): 513-520
6. Petit TL, LeBoutillier JC, Alfano DP, Becker LE (1984) Synaptic development in the human fetus: a morphometric analysis of normal and Down's syndrome neocortex. Exp Neurol 83(1): 13-23
7. Schmidt-Sidor B, Wisniewski KE, Shepard TH, Sersen EA (1990) Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months. Clin Neuropathol 9(4): 181-190
8. Shim KS, Lubec G (2002) Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett 324(3): 209-212
9. Takashima S, Becker LE, Armstrong DL, Chan F (1981) Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome. A quantitative and qualitative Golgi study. Brain Res 225: 1-21
10. Takashima S, Ieshima A, Nakamura H, Becker LE (1989) Dendrites, dementia and the Down syndrome. Brain Dev 11(2): 131-133
11. Vukšić M, Petanjek Z, Rašin MR, Kostović I (2002) Perinatal growth of prefrontal layer III pyramids in Down syndrome. Pediatr Neurol 27(1): 36-38
12. Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G (2001) Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. J Neural Transm [Suppl] 61: 59-70
13. Wierzba-Bobrowicz T, Lewandowska E, Schmidt-Sidor B, Gwiazda E (1999) The comparison of microglia maturation in CNS of normal human fetuses and fetuses with Down's syndrome. Folia Neuropathol 37(4): 227-234