Mass-spectrometrical analysis of proteins encoded on chromosome 21 in human fetal brain

Amino Acids

Volumn 31, Issue 4, 2006, Pages 435-447

  Shin, J H ^a   Krapfenbauer, K ^a,b   Lubec, G ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Preclinical Research   (Switzerland)

Author keywords

Human chromosome 21; Human fetal brain; Ion exchange chromatography; MALDI TOF TOF; Two dimensional gel electrophoresis

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CARBONYL REDUCTASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTATHIONINE BETA SYNTHASE; CYSTATIN B; ENDOGENOUS COMPOUND; MITOCHONDRIAL PROTEIN; PHOSPHORIBOSYLAMINE GLYCINE LIGASE; PYRIDOXAL KINASE;

ANTIBODY SPECIFICITY; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CHROMATOGRAPHY; CHROMOSOME 21; DOWN SYNDROME; EXTRACTION; FETUS; FETUS (ANATOMY); GEL ELECTROPHORESIS; GENE OVEREXPRESSION; HUMAN; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; ULTRACENTRIFUGATION;

BRAIN; CHROMOSOMES, HUMAN, PAIR 21; DOWN SYNDROME; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FETUS; HUMANS; MALE; PROTEINS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 33845231626     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-005-0257-y     Document Type: Article

References (47)

1. K Amano H Sago C Uchikawa T Suzuki SE Kotliarova N Nukina CJ Epstein K Yamakawa 2004 Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome Hum Mol Genet 13 1333 1340
2. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
3. K Brannvall H Hjelm L Korhonen U Lahtinen AE Lehesjoki D Lindholm 2003 Cystatin-B is expressed by neural stem cells and by differentiated neurons and astrocytes Biochem Biophys Res Commun 308 369 374
4. G Brodsky T Barnes J Bleskan L Becker M Cox D Patterson 1997 The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome Hum Mol Genet 6 2043 2050
5. MS Cheon SH Kim ML Yaspo F Blasi Y Aoki K Melen G Lubec 2003a Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I) Amino Acids 24 111 117
6. MS Cheon M Bajo SH Kim JO Claudio AK Stewart D Patterson WD Kruger H Kondoh G Lubec 2003b Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II) Amino Acids 24 119 125
7. MS Cheon SH Kim V Ovod N Kopitar Jerala JI Morgan Y Hatefi T Ijuin T Takenawa G Lubec 2003c Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part III) Amino Acids 24 127 134
8. MS Cheon KS Shim SH Kim A Hara G Lubec 2003d Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part IV) Amino Acids 25 41 47
9. JB de Haan B Susil M Pritchard I Kola 2003 An altered antioxidant balance occurs in Down syndrome fetal organs: implications for the "gene dosage effect" hypothesis J Neural Transm Suppl 67 67 83
10. R Eldridge M Iivanainen R Stern T Koerber BJ Wilder 1983 'Baltic' myoclonus epilepsy: hereditary disorder of childhood made worse by phenytoin Lancet 2 838 842
11. A Elson D Levanon Y Weiss Y Groner 1994 Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: implication for gene dosage in trisomy 21 Biochem J 299 409 415
12. E Engidawork N Baiic M Fountoulakis M Dierssen S Greber-Platzer G Lubec 2001 Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect J Neural Transm Suppl 61 335 346
13. E Engidawork G Lubec 2001 Protein expression in Down syndrome brain Amino Acids 21 331 361
14. E Engidawork G Lubec 2003 Molecular changes in fetal Down syndrome brain J Neurochem 84 895 904
15. CJ Epstein 1995 Down syndrome CR Scriver AL Beaudet WS Sly D Valle The metabolic and molecular bases of inherited disease 7 I McGraw-Hill New York 749 794
16. R Ferrando-Miguel MS Cheon G Lubec 2004 Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5) Amino Acids 26 255 261
17. R Ferrando-Miguel MS Cheon JW Yang G Lubec 2003 Overexpression of transcription factor BACH1 in fetal Down syndrome brain J Neural Transm Suppl 67 193 205
18. M Fountoulakis 2001 Proteomics: current technologies and applications in neurological disorders and toxicology Amino Acids 21 363 381
19. M Fountoulakis JF Juranville M Dierssen G Lubec 2002 Proteomic analysis of the fetal brain Proteomics 2 1547 1576
20. JJ Fuentes L Genesca TJ Kingsbury KW Cunningham M Perez-Riva X Estivill S de la Luna 2000 DSCR1, over-expressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways Hum Mol Genet 9 1681 1690
21. Y Gitton N Dahmane S Baik A Ruiz i Altaba L Neidhardt M Scholze BG Herrmann P Kahlem A Benkahla S Schrinner R Yildirimman R Herwig H Lehrach ML Yaspo HSA21 expression map initiative 2002 A gene expression map of human chromosome 21 orthologues in the mouse Nature 420 586 590
22. T Gulesserian E Engidawork M Fountoulakis G Lubec 2001 Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome J Neural Transm Suppl 61 71 84
23. M Hattori A Fujiyama TD Taylor H Watanabe T Yada HS Park A Toyoda K Ishii Y Totoki DK Choi Y Groner E Soeda M Ohki T Takagi Y Sakaki S Taudien K Blechschmidt A Polley U Menzel J Delabar K Kumpf R Lehmann D Patterson K Reichwald A Rump M Schillhabel A Schudy W Zimmermann A Rosenthal J Kudoh K Schibuya K Kawasaki S Asakawa A Shintani T Sasaki K Nagamine S Mitsuyama SE Antonarakis S Minoshima N Shimizu G Nordsiek K Hornischer P Brant M Scharfe O Schon A Desario J Reichelt G Kauer H Blocker J Ramser A Beck S Klages S Hennig L Riesselmann E Dagand T Haaf S Wehrmeyer K Borzym K Gardiner D Nizetic F Francis H Lehrach R Reinhardt ML Yaspo Chromosome 21 mapping and sequencing consortium 2000 The DNA sequence of human chromosome 21 Nature 405 311 319
24. M Jarvinen A Rinne 1982 Human spleen cysteineproteinase inhibitor: purification, fractionation into isoelectric variants and some properties of the variants Biochim Biophys Acta 708 210 217
25. P Kahlem M Sultan R Herwig M Steinfath D Balzereit B Eppens NG Saran MT Pletcher ST South G Stetten H Lehrach RH Reeves ML Yaspo 2004 Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome Genome Res 14 1258 1267
26. K Karlsson N Cairns G Lubec M Fountoulakis 1999 Enrichment of human brain proteins by heparin chromatography Electrophoresis 20 2970 2976
27. PJ Kingham JM Pocock 2001 Microglial secreted cathepsin B induces neuronal apoptosis J Neurochem 76 1475 1484
28. M Koskiniemi M Donner H Majuri M Haltia R Norio 1974 Progressive myoclonus epilepsy. A clinical and histopathological study Acta Neurol Scand 50 307 332
29. K Krapfenbauer M Fountoulakis G Lubec 2003 A rat brain protein expression map including cytosolic and enriched mitochondrial and microsomal fractions Electrophoresis 24 1847 1870
30. CA Lemere JS Munger GP Shi L Natkin C Haass HA Chapman DJ Selkoe 1995 The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study Am J Pathol 146 848 860
31. P Lescuyer DF Hochstrasser JC Sanchez 2004 Comprehensive proteome analysis by chromatographic protein prefractionation Electrophoresis 25 1125 1135
32. G Lubec M Bajo MS Cheon H Bajova LH Matherly 2003 Increased expression of human reduced folate carrier in fetal Down syndrome brain J Neural Transm Suppl 67 95 103
33. G Lubec E Engidawork 2002 The brain in Down syndrome (TRISOMY 21) J Neurol 249 1347 1356
34. G Lubec K Krapfenbauer M Fountoulakis 2003 Proteomics in brain research: potentials and limitations Prog Neurobiol 69 193 211
35. M Mann RC Hendrickson A Pandey 2001 Analysis of proteins and proteomes by mass spectrometry Annu Rev Biochem 70 437 473
36. RF Miguel A Pollak G Lubec 2005 Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease Brain Res Mol Brain Res 133 1 5
37. R Norio M Koskiniemi 1979 Progressive myoclonus epilepsy: genetic and nosological aspects with special reference to 107 Finnish patients Clin Genet 15 382 398
38. M Peled-Kamar H Degani P Bendel R Margalit Y Groner 1998 Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies Brain Res 810 138 145
39. C Pucharcos JJ Fuentes C Casas S de la Luna S Alcantara ML Arbones E Soriano X Estivill M Pritchard 1999 Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and over-expressed in Down syndrome Eur J Hum Genet 7 704 712
40. A Reymond V Marigo MB Yaylaoglu A Leoni C Ucla N Scamuffa C Caccioppoli ET Dermitzakis R Lyle S Banfi G Eichele SE Antonarakis A Ballabio 2002 Human chromosome 21 gene expression atlas in the mouse Nature 420 582 586
41. PG Righetti A Castagna B Herbert F Reymond JS Rossier 2003 Prefractionation techniques in proteome analysis Proteomics 3 1397 1407
42. A Ritonja W Machleidt AJ Barrett 1985 Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver Biochem Biophys Res Commun 131 1187 1192
43. KS Shim R Ferrando-Miguel G Lubec 2003 Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease J Neural Transm Suppl 67 39 49
44. J-H Shin R Weitzdörfer M Fountoulakis G Lubec 2004 Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain Neurochem Int 45 73 79
45. J-H Shin K Krapfenbauer G Lubec 2005 Column chromatographic prefractionation leads to the detection of 543 different gene products in human fetal brain Electrophoresis 26 2759 2778
46. V Turk W Bode 1991 The cystatins: protein inhibitors of cysteine proteinases FEBS Lett 285 213 219
47. R Vitorino MJ Lobo AJ Ferrer-Correira JR Dubin KB Tomer PM Domingues FM Amado 2004 Identification of human whole saliva protein components using proteomics Proteomics 4 1109 1115