Relation of cerebral small-vessel disease and brain atrophy to mild Parkinsonism in the elderly

Movement Disorders

Volumn 21, Issue 11, 2006, Pages 1914-1919

  Reitz, Christiane ^a   Trenkwalder, Claudia ^b   Kretzschmar, Konrad ^c   Roesler, Andreas ^c   Eckardstein, Arnold V ^d   Berger, Klaus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Center of Parkinsonism and Movement Disorders   (Germany)

^c Zentralklinikum Augsburg ^*  (Germany)

^d Institute of Clinical Chemistry   (Germany)

Author keywords

Cerebral small vessel diseas; Mild pakinsonism signs

Indexed keywords

AGED; ARTICLE; BRADYKINESIA; BRAIN ATROPHY; BRAIN INFARCTION; CEREBROVASCULAR DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GERMANY; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSONISM; PREVALENCE; PRIORITY JOURNAL; RATING SCALE; REST; RIGIDITY; RISK ASSESSMENT; TREMOR; WHITE MATTER;

AGED; AGED, 80 AND OVER; ATROPHY; CEREBROVASCULAR DISORDERS; CONFIDENCE INTERVALS; DEMOGRAPHY; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; ODDS RATIO; PARKINSONIAN DISORDERS; RISK; SEVERITY OF ILLNESS INDEX;

EID: 33845215838     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.21085     Document Type: Article

References (24)

1. Bennett DA, Beckett LA, Murray AM, et al. Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 1996;334:71-76.
2. Louis ED, Luchsinger JA, Tang MX, Mayeux R. Parkinsonian signs in older people: prevalence and associations with smoking and coffee. Neurology 2003;61:24-28.
3. Louis ED, Tang MX, Mayeux R. Parkinsonian signs in older people in a community-based study: risk of incident dementia. Arch Neurol 2004;61:1273-1276.
4. Wilson RS, Schneider JA, Bienias JL, Evans DA, Bennett DA. Parkinsonian like signs and risk of incident Alzheimer disease in older persons. Arch Neurol 2003;60:539-544.
5. Thanvi B, Lo N, Robinson T. Vascular parkinsonism-an important cause of parkinsonism in older people. Age Ageing 2005;34:114-119.
6. van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain 1991; 114(Pt 2):761-774.
7. Ben Shlomo Y. How far are we in understanding the cause of Parkinson's disease? J Neurol Neurosurg Psychiatry 1996;61:4-16.
8. Jellinger KA. Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study. Acta Neuropathol (Berl) 2003;105: 415-419.
9. Mastaglia FL, Johnsen RD, Kakulas BA. Prevalence of stroke in Parkinson's disease: a postmortem study. Mov Disord 2002;17: 772-774.
10. Keil U, Liese AD, Hense HW, et al. Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany. Results from the MONICA Augsburg cohort study 1984-1992. Monitoring trends and determinants in cardiovascular diseases. Eur Heart J 1998;19: 1197-1207.
11. Launer LJ, Oudkerk M, Nilsson LG, et al. CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives. Neuroepidemiology 2000;19:113-120.
12. Fahn S, Elton RL. Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Calne D, Goldstein M, editors. Recent Developments in Parkinson's Disease. Vol. 2. Florham Park, NJ: Macmillan Healthcare Information; 1987.
13. Achten E, Breteler MM, De Leeuw FE, et al. Rating scale for age related brain changes. Imaging decisions. Magn Reson Imaging 2000;4:10-19.
14. Scheltens P, Erkinjunti T, Leys D, et al. White matter changes on CT and MRI: an overview of visual rating scales. European Task Force on Age-Related White Matter Changes. Eur Neurol 1998; 39:80-89.
15. Sibon I, Fenelon G, Quinn NP, Tison F. Vascular parkinsonism. J Neurol 2004;251:513-524.
16. Hughes AJ, Daniel SE, Blankson S, Lees AJ. A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 1993;50: 140-148.
17. Huber SJ, Shuttleworth EC, Christy JA, Chakeres DW, Curtin A, Paulson GW. Magnetic resonance imaging in dementia of Parkinson's disease. J Neurol Neurosurg Psychiatry 1989;52:1221-1227.
18. Schulz JB, Skalej M, Wedekind D, et al. Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy. Ann Neurol 1999;45:65-74.
19. Burton EJ, McKeith IG, Burn DJ, Williams ED, OBrien JT. Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain 2004;127(Pt 4):791-800.
20. Hu MT, White SJ, Chaudhuri KR, Morris RG, Bydder GM, Brooks DJ. Correlating rates of cerebral atrophy in Parkinson's disease with measures of cognitive decline. J Neural Transm 2001;108: 571-580.
21. Tohgi H, Utsugisawa K, Yoshimura M, Yamagata M, Nagane Y, Saitoh K. Reduction in the ratio of beta-preprotachykinin to pre-proenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism. Brain Res 1997;768: 86-90.
22. Tohgi H, Utsugisawa K, Yoshimura M, Nagane Y, Mihara M. Alterations with aging and ischemia in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human putamen. Implications for susceptibility to parkinsonism. Brain Res 1998;791:186-190.
23. Mengesdorf T, Jensen PH, Mies G, Aufenberg C, Paschen W. Down-regulation of parkin protein in transient focal cerebral ischemia: a link between stroke and degenerative disease? Proc Natl Acad Sci U S A 2002;99:15042-15047.
24. Nakane M, Teraoka A, Asato R, Tamura A. Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum. Stroke 1992;23:328-332.