Multimodal image-guided enzyme/prodrug cancer therapy

Journal of the American Chemical Society

Volumn 128, Issue 47, 2006, Pages 15072-15073

  Li, Cong ^a   Winnard Jr , Paul T ^a   Takagi, Tomoyo ^a   Artemov, Dmitri ^a   Bhujwalla, Zaver M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; BIOTIN; CYTOSINE DEAMINASE; DRUG METABOLITE; FLOXURIDINE PHOSPHATE; FLUCYTOSINE; GADOLINIUM; MACROGOL; MALEIMIDE; MATRIX METALLOPROTEINASE; POLYLYSINE; PRODRUG; RHODAMINE;

ARTICLE; BIODEGRADABILITY; CANCER CELL CULTURE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG TRANSFORMATION; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME THERAPY; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMAGING; MULTIMODALITY CANCER THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOSINE DEAMINASE; ENZYME STABILITY; FLUCYTOSINE; HETEROCYCLIC COMPOUNDS; HUMANS; KINETICS; LIGHT; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; POLYLYSINE; PRODRUGS; RHODAMINES; SCATTERING, RADIATION;

EID: 33845200822     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja066199i     Document Type: Article

References (23)

1. (a) Xu, G.; McLeod, H. L. Clin. Cancer Res. 2001, 7, 3314-3324.
2. (b) Bagshawe, K. D.; Sharma, S. K.; Burke, P. J.; Melton, R. D.; Knox, R. J. Curr. Opin. Immunol. 1999, 11, 579-583.
3. Niculescu-Duvaz, I.; Springer, C. J. Adv. Drug Delivery Rev. 1997, 2, 151-172.
4. (a) Ireton, G. C.; McDermott, G.; Black, M. E.; Stoddard, B. L. J. Mol. Biol. 2002, 315, 687-697.
5. (b) Ireton, G. C.; Black, M. E.; Stoddard, B. L. Acta Crystallogr., Sect. D 2001, 57, 1643-1645.
6. Mahan, S. D.; Ireton, G. C.; Stoddard, B. L.; Black, M. E. Biochemistry 2004, 43, 8957-8964.
7. Mahan, S. D.; Ireton, G. C.; Knoeber, C.; Stoddard, B. L.; Black, M. Protein Eng. Des. Sel. 2004, 17, 625-633.
8. Uzgiris, E. E. Invest. Radiol. 2004, 39, 131-137.
9. Dafni, H.; Gilead, A.; Nevo, N.; Eilam, R.; Harmelin, A.; Neeman, M. Magn. Reson. Med. 2003, 50, 904-914.
10. Aboagye, E. O.; Artemov, D.; Senter, P. D.; Bhujwalla, Z. M. Cancer Res. 1998, 58, 4075-4078.
11. (a) Jain, R. K. J. Controlled Release 2001, 74, 7-25.
12. (b) Yuan, F.; Dellian, M.; Fukumura, D.; Leunig, M.; Berk, D. A.; Torchilin, V. P.; Jain, R. K. Cancer Res. 1995, 55, 3752-3756.
13. Aime, S.; Botta, M.; Fasano, M.; Terreno, E. Chem. Soc. Rev. 1998, 27, 19-29.
14. (a) Ipata, P. L.; Cercignani, G. Methods Enzymol. 1978, 51, 395-400.
15. (b) Hayden, M. S.; Linsley, P. S.; Wallace, A. R.; Marquardt, H.; Kerr, D. E. Protein Expr. Purif. 1998, 12, 173-184.
16. Cornish-Bowden, A. Fundamentals of Enzyme Kinetics; Portland Press Ltd: London, 1995; pp 30-37.
17. For detailed information about MTT assay, see: Li, C.; Greenwood, T. R.; Bhujwalla, Z. M.; Glunde, K. Org. Lett. 2006, 8, 3623-3626.
18. Aboagye, E. O.; Bhujwalla, Z. M.; Shungu, D. C.; Glickson, J. D. Cancer Res. 1998, 58, 1063-1067.
19. Hong, S.; Leroueil, P. R.; Janus, E. K.; Peters, J. L.; Kober, M. M.; Islam, M. T.; Orr, B. G.; Baker, J. R., Jr.; Banaszak Holl, M. M. Bioconjugate Chem. 2006, 17, 728-734.
20. (a) Harris, J. M.; Chess, R. B. Nat. Rev. Drug Discovery 2003, 2, 214-221.
21. (b) Veronese, F. M.; Harris, J. M. Adv. Drug Delivery Syst. 2002, 54 (4), whole issue.
22. (a) Ishibashi, O.; Mori, Y.; Kurokawa, T.; Kumegawa, M. Cancer Biochem. Biophys. 1999, 17, 69-78.
23. (b) Munoz-Najar, U. M.; Neurath, K. M.; Vumbaca, F.; Claffey, K. P. Oncogene 2006, 25, 2379-2392.