Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

Metabolism: Clinical and Experimental

Volumn 56, Issue 1, 2007, Pages 44-48

  Hayakawa, Tetsuo ^a,b   Takamura, Toshinari ^a,b   Abe, Toshio ^a,b   Kaneko, Shuichi ^a,b  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b Kanazawa Municipal Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; INSULIN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; DIABETES MELLITUS; DNA; FATTY ACIDS, NONESTERIFIED; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33845187577     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2006.08.020     Document Type: Article

References (37)

1. Neves S.R., Ram P.T., and Lyengar R. G protein pathway. Science 296 (2002) 1636-1639
2. Siffert W., Rosskopf D., Siffert G., et al. Association of a human G-protein β3 subunit variant with hypertension. Nat Genet 18 (1998) 45-48
3. Siffert W., Forster P., Jöckel K.H., et al. Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals. J Am Soc Nephrol 10 (1999) 1921-1931
4. Ishikawa K., Imai Y., Katsuya T., et al. Human G-protein β3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens 13 (2000) 140-145
5. Blüthner M., Schmidt S., Siffert W., et al. Increased frequency of G-protein β3-subunit 825 T allele in dialyzed patients with type 2 diabetes. Kidney Int 55 (1999) 1247-1250
6. Schunkert H., Hense H.W., Döring A., et al. Association between a polymorphism in the G protein β3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 32 (1998) 510-513
7. Benjafield A.V., Jeyasingam C.L., Nyholt D.R., et al. G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension 32 (1998) 1094-1097
8. Dzida G., Golon-Siekierska P., Puźniak A., et al. G-protein β3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus. Med Sci Monit 8 (2002) CR597-CR602
9. Zychma M.J., Zukowska-Szczechowska E., Ossowska-Szymkowicz I., et al. G-protein β3 subunit C825T variant, nephropathy and hypertension in patients with type 2 (non-insulin-dependent) diabetes mellitus. Am J Nephrol 20 (2000) 305-310
10. Brand E., Wang J.G., Herrmann S.M., et al. An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gβ3 C825T polymorphism. J Hypertens 21 (2003) 729-737
11. Brand E., Herrmann S.M., Nicaud V., et al. The 825C/T polymorphism of the G-protein subunit β3 is not related to hypertension. Hypertension 33 (1999) 1175-1178
12. Beige J., Hohenbleicher H., Distler A., et al. G-protein β3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension 33 (1999) 1049-1051
13. Snapir A., Heinonen P., Tuomainen T.P., et al. G-protein β3 subunit C825T polymorphism: no association with risk for hypertension and obesity. J Hypertens 19 (2001) 2149-2155
14. Fernández-Real J.M., Peñarroja G., Richart C., et al. G protein β3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes. Hypertension 41 (2003) 124-129
15. Hauner H., Meier M., Jöckel K.H., et al. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein β3 subunit gene (GNB3) C825T polymorphism. Phamacogenetics 13 (2003) 453-459
16. Poch E., González-Núñez D., Compte M., et al. G-protein β3-subunit gene variant, blood pressure and erythrocyte sodium/lithium countertransport in essential hypertension. Br J Biomed Sci 59 (2002) 101-104
17. Benjafield A.V., Lin R., Dalziel B., et al. G-protein β3 subunit gene splice variant in obesity and overweight. Int J Obes 25 (2001) 777-780
18. Beige J., Ringel J., Distler A., et al. G-protein β3-subunit C825T genotype and nephropathy in diabetes mellitus. Nephrol Dial Transplant 15 (2000) 1384-1387
19. Fogarty D.G., Zychma M.J., Scott L.J., et al. The C825T polymorphism in the human G-protein β3 subunit gene is not associated with diabetic nephropathy in type I diabetes mellitus. Diabetologia 41 (1998) 1304-1308
20. Gumprecht J., Zychma M.J., Grzeszczak W., et al. Transmission of G-protein β3 subunit C825T alleles to offspring affected with end-stage renal disease. Am J Nephrol 21 (2001) 368-372
21. Shcherbak N.S., and Schwartz E.I. The C825T polymorphism in the G-protein β3 subunit gene and diabetic complications in IDDM patients. J Hum Genet 46 (2001) 188-191
22. Tozawa Y. G protein Beta3 subunit variant: tendency of increasing susceptibility to hypertension in Japanese. Blood Press 10 (2001) 131-134
23. Izawa H., Yamada Y., Okada T., et al. Prediction of genetic risk for hypertension. Hypertension 41 (2003) 1035-1040
24. Yamamoto M., Abe M., Jin J.J., et al. Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in Japanese. Biochem Biophys Res Commun 316 (2004) 744-748
25. Kato N., Sugiyama T., Morita H., et al. G protein β3 subunit variant and essential hypertension in Japanese. Hypertension 32 (1998) 935-938
26. Shioji K., Kokubo Y., Mannami T., et al. Association between hypertension and the α-adducin, β1-adrenoreceptor, and G-protein β3 subunit genes in the Japanese population; the Suita study. Hypertens Res 27 (2004) 31-37
27. Ohshiro Y., Ueda K., Wakasaki H., et al. Analysis of 825C/T polymorphism of G protein β3 subunit in obese/diabetic Japanese. Biochem Biophys Res Commun 286 (2001) 678-680
28. Suwazono Y., Okubo Y., Kobayashi E., et al. Lack of association between human G-protein β3 subunit variant and overweight in Japanese workers. Obes Res 12 (2004) 4-8
29. Alberti K.G.M.M., and Zinnet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15 (1998) 539-553
30. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
31. Farfel Z., Bourne H.R., and Iiri T. The expanding spectrum of G protein disease. N Engl J Med 340 (1999) 1012-1020
32. Virchow S., Ansorge N., Rübben H., et al. Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein β3 subunit 825 T-allele. FEBS Lett 436 (1998) 155-158
33. Siffert W., Rosskopf D., Moritz A., et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest 96 (1995) 759-766
34. Moxham C.M., Hod Y., and Malbon C.C. Induction of Gαi2-specific antisense RNA in vivo inhibits neonatal growth. Science 260 (1993) 991-995
35. Reydén M., Faulds G., Hoffstedt J., et al. Effect of the (C825T) G β3polymorphism on adrenoreceptor-mediated lipolysis in human fat cells. Diabetes 51 (2002) 1601-1608
36. Pietruck F., Spleiter S., Daul A., et al. Enhanced G protein activation in IDDM patents with diabetic nephropathy. Diabetologia 41 (1998) 94-100
37. Rosskopf D., Busch S., Manthey I., et al. G protein β3 gene. Structure, promoter, and additional polymorphisms. Hypertension 36 (2000) 33-41