Reduced ability of penicillin to eradicate ingested group A streptococci from epithelial cells: Clinical and pathogenetic implications

Clinical Infectious Diseases

Volumn 43, Issue 11, 2006, Pages 1398-1406

  Kaplan, Edward L ^a,c   Chhatwal, Gursharan S ^b   Rohde, Manfred ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CEFALOTIN; CLINDAMYCIN; ERYTHROMYCIN; PENICILLIN DERIVATIVE; PENICILLIN V;

ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CANCER CELL CULTURE; DRUG PENETRATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LARYNX MUCOSA; LUNG CARCINOMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION; TRANSMISSION ELECTRON MICROSCOPY; UPPER RESPIRATORY TRACT INFECTION;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CELL LINE; CEPHALOTHIN; CLINDAMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; EPITHELIAL CELLS; ERYTHROMYCIN; HUMANS; MICROBIAL SENSITIVITY TESTS; PENICILLIN V; STREPTOCOCCUS PYOGENES;

EID: 33751569716     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/508773     Document Type: Article

References (21)

1. LaPenta D, Rubens C, Chi E, Cleary PP. Group A streptococci efficiently invade human respiratory epithelial cells. Proc Natl Acad Sci USA 1994;91:12115-9.
2. Molinari G, Rohde M, Guzman CA, Chhatwal GS. Two distinct pathways for the invasion of Streptococcus pyogenes in non-phagocytic cells. Cell Microbiol 2000;2:145-54.
3. Marouni MJ, Barzilai A, Keller N, Rubenstein E, Sela S. Intracellular survival of persistent group A streptococci in cultured epithelial cells. Int J Med Microbiol 2004; 294:27-33.
4. Medina E, Goldmann O, Toppel, AW, Chhatwal GS. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J Infect Dis 2003; 187:597-603.
5. Gastanaduy AS, Kaplan EL, Huwe BB, McKay C, Wannamaker LW. Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis. Lancet 1980; 2:498-502.
6. Kaplan EL, Johnson DR. Unexplained reduced efficacy of oral penicillin V and intramuscular benzathine penicillin G in the eradication of group A streptococci from children with acute pharyngitis. Pediatrics 2001; 108:1180-6.
7. Kaplan EL, Gastanaduy AS, Huwe BB. The role of the carrier in treatment failures following antibiotic therapy for group A streptococci in the upper respiratory tract. J Lab Clin Med 1981; 98:326-35.
8. Dajani A, Taubert K, Ferrieri P, Peter G, Shulman ST. Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals. Pediatrics 1995;96:758-64.
9. Bisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH. Practice guidelines for the diagnosis and management of group A streptococcal pharyngilis. Infections Diseases Society of America. Clin Infect Dis 2002; 35:113-25.
10. Report of the Committee on Infections Diseases of the American Academy of Pediatrics. American Academy of Pediatrics; Evanston, IL, 2003.
11. Kaplan EL, Mendis S, Bisno A, et al. Rheumatic fever and rheumatic heart disease - report of a World Health Organization expert consultation. WHO Technical Report Series 923. Geneva: World Health Organization, 2004.
12. Medina E, Rohde M, Chhatwal GS. Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence. Infect Immun 2003; 71:5376-80.
13. Neeman R, Keller N, Barzilai A, Korenman Z., Sela S. Prevalence of internalisation-associated gene, prtF1, among persisting group A streptococcus strains isolated from asymptomatic carriers. Lancet 1998;352: 1974-7.
14. Rohde M, Müller E, Chhatwal GS, Talay SR. Host cell caveolae act as an entry-port for group A streptococci. Cell Microbiol 2003; 5:323-42.
15. Spurr, AR. A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 1969; 26:31-43.
16. Casey JR, Pichichero ME. Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Clin Infect Dis 2004; 38:1526-34.
17. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillophnryngitis in children. Pediatrics 2004; 113:866-82.
18. Sela S, Barzilai A. Why do we fail with penicillin in the treatment of group A streptococcus infections? Ann Med 1999; 31:303-7.
19. Shulman ST, Gerber MA. So what's wrong with penicillin for strep throat? Pediatrics 2004; 113:1816-9.
20. Bisno AL. Are cephalosporins superior to penicillin for treatment of acute streptococcal pharyngitis? Clin Infect Dis 2004; 38:1535-7.
21. Kaplan EL, Cornaglia G. Persistent macrolide resistance among group A streptococci: the lack of accomplishment after 4 decades. Clin Infect Dis 2005; 41:609-11.