Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence

Infection and Immunity

Volumn 71, Issue 9, 2003, Pages 5376-5380

  Medina, Eva ^a   Rohde, Manfred ^a   Chhatwal, Gursharan S ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; HOST RESISTANCE; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PHENOTYPE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; STREPTOCOCCUS PYOGENES;

ANIMALS; COLONY COUNT, MICROBIAL; CYTOPLASM; FEMALE; MICE; MICE, INBRED C3H; MICROSCOPY, ELECTRON; NEUTROPHILS; PHAGOCYTOSIS; PHAGOSOMES; PHENOTYPE; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; VIRULENCE;

EID: 0042825310     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.9.5376-5380.2003     Document Type: Article

References (14)

1. Betschel, S. D., S. M. Borgia, N. L. Barg, D. E. Low, and J. C. S. De Azavedo. 1998. Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S. Infect. Immun. 66:1671-1679.
2. Cossart, P., M. F. Vicente, J. Mengaud, F. Baquero, J. C. Perez-Diaz, and P. Berche. 1989. Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation. Infect. Immun. 57:3629-3636.
3. Efstratiou, A. 2000. Group A streptococci in the 1990s. J. Antimicrob. Chemother. 45(Suppl.):3-12.
4. Engleberg, N. C., A. Heath, A. Miller, C. Rivera, and V. J. DiRita. 2001. Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection. J. Infect. Dis. 183:1043-1054.
5. Fischetti, V. A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285-314.
6. Goldmann, O., G. S. Chhatwal, and E. Medina. 2003. Immune mechanisms underlying host susceptibility to infection with group A streptococci. J. Infect. Dis. 187:854-861.
7. Lei, B., F. R. DeLeo, N. P. Hoe, M. R. Graham, S. M. Mackie, R. L. Cole, M. Liu, H. R. Hill, D. E. Low, M. J. Federle, J. R. Scott, and J. M. Musser. 2001. Evasion of human innate and acquired immunity by a bacterial homologue of CD11b that inhibits opsonophagocytosis. Nat. Med. 7:1298-1305.
8. Limbago, B., V. Penumalli, B. Weinrick, and J. R. Scott. 2000. Role of streptolysin O in a mouse model of invasive group A streptococcal disease. Infect. Immun. 68:6384-6390.
9. Medina, E., O. Goldmann, M. Rohde, A. Lengeling, and G. S. Chhatwal. 2001. Genetic control of susceptibility to group A streptococcal infection in mice. J. Infect. Dis. 184:846-852.
10. Medina, E., O. Goldmann, A. W. Toppel, and G. S. Chhatwal. 2003. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J. Infect. Dis. 187:597-603.
11. Raeder, R., and M. D. P. Boyle. 1993. Association of type II immunoglobulin G-binding protein expression and survival of group A streptococci in human blood. Infect. Immun. 61:3696-3702.
12. Ravins, M., J. Jaffe, E. Hanski, I. Shetzigovski, S. Natanson-Yaron, and A. E. Moses. 2000. Characterization of a mouse-passaged, highly encapsulated variant of group A streptococcus in in vitro and in vivo studies. J. Infect. Dis. 182:1702-1711.
13. Voyich, J. M., D. E. Sturdevant, K. R. Braughton, S. D. Kobayashi, B. Lei, K. Virtaneva, D. W. Dorward, J. M. Musser, and F. R. DeLeo. 2003. Genome-wide protective response used by group A streptococcus to evade destruction by human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 100:1996-2001.
14. Wessels, M. R., A. E. Moses, J. B. Goldberg, and T. J. DiCesare. 1991. Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci. Proc. Natl. Acad. Sci. USA 88:8317-8321.