Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro

Journal of Cellular Physiology

Volumn 190, Issue 1, 2002, Pages 38-45

  Lemire, Joan M ^c   Merrilees, Mervyn J ^b   Braun, Kathleen R ^a   Wight, Thomas N ^a,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOPE HEART INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOGLYCAN; RNA; TRYPSIN; VERSICAN;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; CELL ADHESION; CELL CONTACT; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; IN VITRO STUDY; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RETROVIRUS; SMOOTH MUSCLE FIBER;

ALTERNATIVE SPLICING; ANIMALS; ARTERIES; BLOTTING, NORTHERN; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; EXTRACELLULAR MATRIX; GENE EXPRESSION; LECTINS, C-TYPE; MALE; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH, VASCULAR; PROTEIN ISOFORMS; PROTEOCHONDROITIN SULFATES; RATS; RATS, INBRED F344; RNA, MESSENGER; TRANSFECTION; VERSICANS;

MARTES PENNANTI; UNIDENTIFIED RETROVIRUS;

EID: 0036132541     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10043     Document Type: Article

References (39)

1. Versican enhances locomotion of astrocytoma cells and reduces cell adhesion through its G1 domain
2. The versican C-type lectin domain recognizes the adhesion protein tenascin-R
3. Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican
4. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid
5. Distribution of the large aggregating proteoglycan versican in adult human tissues
6. Expression of the G1 domain of aggrecan interferes with chondrocyte attachment and adhesion
7. Long-term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes
8. Enhancing the efficiency of DNAmediated gene transfer in mammalian cells
9. A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican
10. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells
11. Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate
12. Vascular smooth muscle cell detachment from elastin and migration through elastic laminae is promoted by chondroitin sulfate-induced "shedding" of the 67-kDa cell surface elastin binding protein
13. 2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican
14. Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing
15. Hyaluronate binding properties of versican
16. Versican/PG-M isoforms in vascular smooth muscle cells
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18. Improved retroviral vectors for gene transfer and expression
19. Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
20. Immunohistochemical localization of extracellular matrix components in human breast tumours with special reference to PG-M/versican
21. Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells
22. Biochemical and Ultrastructural Studies of proteoheparan sulfates synthesized by PYS-2, a basement membrane-producing cell line
23. Brain derived versican V2 is a patent inhibitor of axonal growth
24. Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells
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26. Interference reflection microscopy in cell biology: Methodology and applications
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28. The vascular extracellular matrix
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30. Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates
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32. Aggrecan and link protein affect cell adhesion to culture plates and to type II collagen
33. Cell adhesion and proliferation mediated through the G1 domain of versican
34. Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry
35. Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment region in mouse and human tissues
36. The G3 domain of versican enhances cell proliferation via epidermal growth factor-like motifs
37. Multiple domains of the large fibroblast proteoglycan, versican
38. Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis