FOXL2 in the pituitary: Molecular, genetic, and developmental analysis

Molecular Endocrinology

Volumn 20, Issue 11, 2006, Pages 2796-2805

  Ellsworth, Buffy S ^a   Egashira, Noboru ^b   Haller, Jodi L ^c   Butts, Darcy L ^a   Cocquet, Julie ^d   Clay, Colin M ^c   Osamura, Robert Y ^b   Camper, Sally A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b TOKAI UNIVERSITY   (Japan)

^c Department of Environmental and Radiological Health Sciences   (United States)

^d Hopital Cochin ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; ETOPOSIDE; HYBRID PROTEIN; PROLACTIN; THYROTROPIN; TRANSCRIPTION FACTOR; TRANSRIPTION FACTOR FOXL2; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL EXPERIMENT; ARTICLE; CGA GENE; CONTROLLED STUDY; FEMALE INFERTILITY; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HYPOPHYSIS; HYPOPHYSIS CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SF1 GENE; TRANSCRIPTION REGULATION;

ANIMALS; EMBRYO; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PITUITARY GLAND; PITUITARY GLAND, ANTERIOR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 33751528497     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0303     Document Type: Article

References (56)

1. Lehmann OJ, Sowden JC, Carlsson P, Jordan T, Bhattacharya SS 2003 Fox's in development and disease. Trends Genet 19:339-344
2. Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G 2001 The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 27:159-166
3. Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG 1998 Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 12:1691-1704
4. Cocquet J, Pailhoux E, Jaubert F, Servel N, Xia X, Pannetier M, De Baere E, Messiaen L, Cotinot C, Fellous M, Veitia RA 2002 Evolution and expression of FOXL2. J Med Genet 39:916-921
5. Fuhrer D 2002 Lessons from studies of complex genetic disorders: identification of FOXL2 - a novel transcription factor on the wing to fertility. Eur J Endocrinol 146:15-18
6. Prueitt RL, Zinn AR 2001 A fork in the road to fertility. Nat Genet 27:132-134
7. Richards JS, Sharma SC, Falender AE, Lo YH 2002 Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins. Mol Endocrinol 16:580-599
8. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG 1999 Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell 97:587-598
9. Ellsworth BS, Burns AT, Escudero KW, Duval DL, Nelson SE, Clay CM 2003 The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol 206:93-111
10. Pisarska MD, Bae J, Klein C, Hsueh AJ 2004 Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology 145:3424-3433
11. Ottolenghi C, Omari S, Garcia-Ortiz JE, Uda M, Crisponi L, Forabosco A, Pilia G, Schlessinger D 2005 Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet 14:2053-2062
12. Gage PJ, Suh H, Camper SA 1999 Dosage requirement of Pitx2 for development of multiple organs. Development 126:4643-4651
13. Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M 2004 The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131:933-942
14. Uda M, Ottolenghi C, Crisponi L, Garcia JE, Deiana M, Kimber W, Forabosco A, Cao A, Schlessinger D, Pilia G 2004 Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13:1171-1181
15. Frawley LS, Boockfor FR 1991 Mammosomatotropes: presence and functions in normal and neoplastic pituitary tissue. Endocr Rev 12:337-355
16. Gordon DF, Lewis SR, Haugen BR, James RA, McDermott MT, Wood WM, Ridgway EC 1997 Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin β-subunit promoter. J Biol Chem 272:24339-24347
17. West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ 2004 Regulation of the follicle-stimulating hormone β gene by the LHX3 LIM-homeodomain transcription factor. Endocrinology 145:4866-4879
18. Halvorson LM, Ito M, Jameson JL, Chin WW 1998 Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone β-subunit gene expression. J Biol Chem 273:14712-14720
19. Windle JJ, Weiner RI, Mellon PL 1990 Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol 4:597-603
20. Akerblom IE, Ridgway EC, Mellon PL 1990 An α-subunit-secreting cell line derived from a mouse thyrotrope tumor. Mol Endocrinol 4:589-596
21. Thomas P, Mellon PL, Turgeon J, Waring DW 1996 The L β T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Endocrinology 137:2979-2989
22. Turgeon JL, Kimura Y, Waring DW, Mellon PL 1996 Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol 10:439-450
23. Jensen FC, Girardi AJ, Gilden RV, Koprowski H 1964 Infection of human and simian tissue cultures with rous sarcoma virus. Proc Natl Acad Sci USA 52:53-59
24. Kit S, Dubbs DR, DeTorres RA, Melnick JL 1965 Enhanced thymidine kinase activity following infection of green monkey kidney cells by simian adenoviruses, simian papovavirus SV40, and an adenovirus-SV40 "hybrid." Virology 27:453-457
25. Cushman LJ, Showalter AD, Rhodes SJ 2002 Genetic defects in the development and function of the anterior pituitary gland. Ann Med 34:179-191
26. Watkins-Chow DE, Camper SA 1998 How many homeobox genes does it take to make a pituitary gland? Trends Genet 14:284-290
27. Burgess R, Lunyak V, Rosenfeld M 2002 Signaling and transcriptional control of pituitary development. Curr Opin Genet Dev 12:534-539
28. Sheng HZ, Moriyama K, Yamashita T, Li H, Potter SS, Mahon KA, Westphal H 1997 Multistep control of pituitary organogenesis. Science 278:1809-1812
29. Raetzman LT, Ward R, Camper SA 2002 Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development 129:4229-4239
30. Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carriere C, Ryan AK, Miller AP, Zuo L, Gleiberman AS, Andersen B, Beamer WG, Rosenfeld MG 1996 Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384:327-333
31. Gage PJ, Brinkmeier ML, Scarlett LM, Knapp LT, Camper SA, Mahon KA 1996 The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation. Mol Endocrinol 10:1570-1581
32. Cushman LJ, Watkins-Chow DE, Brinkmeier ML, Raetzman LT, Radak AL, Lloyd RV, Camper SA 2001 Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. Hum Mol Genet 10:1141-1153
33. Charles MA, Saunders TL, Wood WM, Owens K, Parlow AF, Camper SA, Ridgway EC, Gordon DF 2006 Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol 20:1366-1377
34. Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H 1998 Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379-383
35. Stark K, Vainio S, Vassileva G, McMahon AP 1994 Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372:679-683
36. Yamaguchi TP, Bradley A, McMahon AP, Jones S 1999 A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126:1211-1223
37. Ericson J, Norlin S, Jessell TM, Edlund T 1998 Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125:1005-1015
38. Burgering BM, Medema RH 2003 Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 73:689-701
39. Medema RH, Kops GJ, Bos JL, Burgering BM 2000 AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-787
40. Perreault N, Katz JP, Sackett SD, Kaestner KH 2001 Foxl1 controls the Wnt/β-catenin pathway by modulating the expression of proteoglycans in the gut. J Biol Chem 276:43328-43333
41. Carlsson P, Mahlapuu M 2002 Forkhead transcription factors: key players in development and metabolism. Dev Biol 250:1-23
42. Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA 2005 Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem 280:13809-13816
43. Accili D, Arden KC 2004 FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426
44. Bourguignon C, Li J, Papalopulu N 1998 XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm. Development 125:4889-4900
45. Crisponi L, Uda M, Deiana M, Loi A, Nagaraja R, Chiappe F, Schlessinger D, Cao A, Pilia G 2004 FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences. Genomics 83:757-764
46. Beysen D, Raes J, Leroy BP, Lucassen A, Yates JR, Clayton-Smith J, Ilyina H, Brooks SS, Christin-Maitre S, Fellous M, Fryns JP, Kim JR, Lapunzina P, Lemyre E, Meire F, Messiaen LM, Oley C, Splitt M, Thomson J, Peer YV, Veitia RA, De Paepe A, De Baere E 2005 Deletions involving long-range conserved nongenic sequences upstream and downstream of FOXL2 as a novel disease-causing mechanism in blepharophimosis syndrome. Am J Hum Genet 77:205-218
47. Nasonkin IO, Ward RD, Raetzman LT, Seasholtz AF, Saunders TL, Gillespie PJ, Camper SA 2004 Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet 13:2727-2735
48. Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA 2003 TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol 17:2152-2161
49. Andersen B, Rosenfeld MG 2001 POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev 22:2-35
50. Gage PJ, Lossie AC, Scarlett LM, Lloyd RV, Camper SA 1995 Ames dwarf mice exhibit somatotrope commitment but lack growth hormone-releasing factor response. Endocrinology 136:1161-1167
51. Sheng HZ, Zhadanov AB, Mosinger Jr B, Fujii T, Bertuzzi S, Grinberg A, Lee EJ, Huang SP, Mahon KA, Westphal H 1996 Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 272:1004-1007
52. Nowakowski RS, Lewin SB, Miller MW 1989 Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J Neurocytol 18:311-318
53. Douglas KR, Brinkmeier ML, Kennell JA, Eswara P, Harrison TA, Patrianakos AI, Sprecher BS, Potok MA, Lyons Jr RH, MacDougald OA, Camper SA 2001 Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Mamm Genome 12:843-851
54. Brinkmeier ML, Gordon DF, Dowding JM, Saunders TL, Kendall SK, Sarapura VD, Wood WM, Ridgway EC, Camper SA 1998 Cell-specific expression of the mouse glycoprotein hormone α-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells. Mol Endocrinol 12:622-633
55. Hogan BL, Beddington RS, Costantini F, Lacey E 1994 Manipulating the mouse embryo: a laboratory manual. Plainview, NY: Cold Spring Harbor Laboratory Press
56. Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ 2005 PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol 19:1893-1903